Keyword search (4,164 papers available)

"Alkaloids" Keyword-tagged Publications:

Title Authors PubMed ID
1 Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ; 41779670
BIOLOGY
2 A Highly Characterized Synthetic Landing Pad System for Precise Multicopy Gene Integration in Yeast. Bourgeois L, Pyne ME, Martin VJJ 30372609
BIOLOGY
3 Microbial Factories for the Production of Benzylisoquinoline Alkaloids. Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ 26775900
BIOLOGY
4 Engineering of a Nepetalactol-Producing Platform Strain of Saccharomyces cerevisiae for the Production of Plant Seco-Iridoids. Campbell A, Bauchart P, Gold ND, Zhu Y, De Luca V, Martin VJ 26981892
CSFG
5 Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids. Pyne ME, Narcross L, Fossati E, Bourgeois L, Burton E, Gold ND, Martin VJ 27417930
CSFG
6 Mining Enzyme Diversity of Transcriptome Libraries through DNA Synthesis for Benzylisoquinoline Alkaloid Pathway Optimization in Yeast. Narcross L, Bourgeois L, Fossati E, Burton E, Martin VJ 27442619
BIOLOGY

 

Title:Microbial Factories for the Production of Benzylisoquinoline Alkaloids.
Authors:Narcross L,  Fossati E,  Bourgeois L,  Dueber JE,  Martin VJJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/26775900?dopt=Abstract
DOI:10.1016/j.tibtech.2015.12.005
Publication:Trends in biotechnology
Keywords:aromatic amino acids;  benzylisoquinoline alkaloids;  biosecurity;  dopamine;  microbial synthesis;  morphinans; 
PMID:26775900 Category:Trends Biotechnol Date Added:2019-06-07
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada; Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec H4B 1R6, Canada.
2 Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94704, USA.
3 Department of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada; Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec H4B 1R6, Canada. Electronic address: vincent.martin@concordia.ca.

Description:

Microbial Factories for the Production of Benzylisoquinoline Alkaloids.

Trends Biotechnol. 2016 Mar;34(3):228-241

Authors: Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ

Abstract

Benzylisoquinoline alkaloids (BIAs) are a family of ~2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to microbial sources could provide a scalable and flexible source of these compounds in the future. This review details the current status of microbial BIA synthesis and derivatization, including rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in a microbial host.

PMID: 26775900 [PubMed - indexed for MEDLINE]




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