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PubMed Publications| Keyword search (4,163 papers available) |  |
"Alzheimer" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment | Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T; | 41929984 HKAP |
| 2 | Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact | Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H; | 41358624 PSYCHOLOGY |
| 3 | The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort | Jobin B; Phillips NA; Frasnelli J; Boller B; | 40944318 PSYCHOLOGY |
| 4 | The longitudinal effects of global and regional brain measurements on cognitive abilities | Hosseininasabnajar F; Kakinami L; | 40739300 SOH |
| 5 | Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions | Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM; | 40585093 PSYCHOLOGY |
| 6 | In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis | Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS; | 40516590 CHEMBIOCHEM |
| 7 | Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer s disease | Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None; | 40347524 CONCORDIA |
| 8 | Connected speech profiles in mild cognitive impairment reflect global cognition | Pellerin S; Houzé B; Bedetti C; Phillips N; Brambati SM; | 40232260 PSYCHOLOGY |
| 9 | Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research | Smith EE; Phillips NA; Feldman HH; Borrie M; Ganesh A; Henri-Bhargava A; Desmarais P; Frank A; Badhwar A; Barlow L; Bartha R; Best S; Bethell J; Bhangu J; Black SE; Bocti C; Bronskill SE; Burhan AM; Calon F; Camicioli R; Campbell B; Collins DL; Dadar M; DeMarco ML; Ducharme S; Duchesne S; Einstein G; Fisk JD; Gawryluk JR; Grossman L; Ismail Z; Itzhak I; Joshi M; Harrison A; Kroger E; Kumar S; Laforce R; Lanctot KL; Lau M; Lee L; Masellis M; Massoud F; Mitchell SB; Montero-Odasso M; Myers Barnett K; Nygaard HB; Pasternak SH; Peters J; Rajah MN; Robillard JM; Rockwood K; Rosa-Neto P; Seitz DP; Soucy JP; Trenaman SC; Wellington CL; Zadem A; Chertkow H; | 39893139 CONCORDIA |
| 10 | Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease | Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP; | 39878233 CONCORDIA |
| 11 | Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) | Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; | 39636028 HKAP |
| 12 | Cognitive Speed in Neurodegenerative Disease: Comparing Mean Rate and Inconsistency Within and Across the Alzheimer's and Lewy Body Spectra in the COMPASS-ND Study | Caballero HS; McFall GP; Gee M; MacDonald S; Phillips NA; Fogarty J; Montero-Odasso M; Camicioli R; Dixon RA; | 38875040 PSYCHOLOGY |
| 13 | The effectiveness of exercise interventions targeting sleep in older adults with cognitive impairment or Alzheimer's disease and related dementias (AD/ADRD): A systematic review and meta-analysis | Arsenio Páez, Emmanuel Frimpong, Melodee Mograss, Thien Thanh Dang-Vu | 38462491 HKAP |
| 14 | Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease | Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauthier CJ; Turner GR; Spreng RN; | 38388425 PSYCHOLOGY |
| 15 | Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer's disease spectrum | Belasso CJ; Cai Z; Bezgin G; Pascoal T; Stevenson J; Rahmouni N; Tissot C; Lussier F; Rosa-Neto P; Soucy JP; Rivaz H; Benali H; | 37920382 PERFORM |
| 16 | Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments | Vandersteen C; Plonka A; Manera V; Sawchuk K; Lafontaine C; Galery K; Rouaud O; Bengaied N; Launay C; Guérin O; Robert P; Allali G; Beauchet O; Gros A; | 37416323 CONCORDIA |
| 17 | Olfactory function reflects episodic memory performance and atrophy in the medial temporal lobe in individuals at risk for Alzheimer's disease | Papadatos Z; Phillips NA; | 37146503 PSYCHOLOGY |
| 18 | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer's disease | Giroud N; Pichora-Fuller MK; Mick P; Wittich W; Al-Yawer F; Rehan S; Orange JB; Phillips NA; | 36911511 CRDH |
| 19 | Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex | Olajide OJ; La Rue C; Bergdahl A; Chapman CA; | 36275011 HKAP |
| 20 | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy | Brodeur C; Belley É; Deschênes LM; Enriquez-Rosas A; Hubert M; Guimond A; Bilodeau J; Soucy JP; Macoir J; | 35629330 IMAGING |
| 21 | Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab | Chertkow H; Rockwood K; Hogan DB; Phillips N; Montero-Odasso M; Amanullah S; Black S; Bocti C; Borrie M; Feldman H; Freedman M; Hsiung R; Kirk A; Masellis M; Nygaard H; Rajji T; Verret L; | 34912492 PSYCHOLOGY |
| 22 | Comment on the article "Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome 486 (2020) 110102" | Arsalan Rahimabadi | 34843739 PERFORM |
| 23 | Visual Performance and Cortical Atrophy in Vision-Related Brain Regions Differ Between Older Adults with (or at Risk for) Alzheimer's Disease | Sana Rehan | 34397410 CRDH |
| 24 | Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex | Olajide OJ; Chapman CA; | 34144329 PSYCHOLOGY |
| 25 | Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease. | Olajide OJ, Suvanto ME, Chapman CA | 33495355 PSYCHOLOGY |
| 26 | Category-specific verb-semantic deficits in Alzheimer's disease: Evidence from static and dynamic action naming. | de Almeida RG, Mobayyen F, Antal C, Kehayia E, Nair VP, Schwartz G | 33455543 PSYCHOLOGY |
| 27 | Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity. | Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, Oluyomi OO, Idowu OK, Kareem R, Asogwa NT, Adeniyi PA | 33420680 PSYCHOLOGY |
| 28 | A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer's Disease | Badji A; de la Colina AN; Boshkovski T; Sabra D; Karakuzu A; Robitaille-Grou MC; Gros C; Joubert S; Bherer L; Lamarre-Cliche M; Stikov N; Gauthier CJ; Cohen-Adad J; Girouard H; | 32741837 PERFORM |
| 29 | Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment | Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P, | 32582834 PERFORM |
| 30 | Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment | Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; | 31758692 CRDH |
| 31 | Computer-Aided Diagnosis System of Alzheimer's Disease Based on Multimodal Fusion: Tissue Quantification Based on the Hybrid Fuzzy-Genetic-Possibilistic Model and Discriminative Classification Based on the SVDD Model. | Lazli L, Boukadoum M, Ait Mohamed O | 31652635 ENCS |
| 32 | The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study. | Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ | 31309917 PSYCHOLOGY |
| 33 | Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve | Hilary D Duncan | 29287966 PSYCHOLOGY |
| 34 | Flavanone glycosides inhibit β-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aβ aggregation in the amyloidogenic pathway. | Ali MY, Jannat S, Edraki N, Das S, Chang WK, Kim HC, Park SK, Chang MS | 31194956 BIOLOGY |
| 35 | Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment. | Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J | 28522082 PERFORM |
| 36 | Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. | Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative | 29396637 PERFORM |
| Title: | In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis | ||||
| Authors: | Silva MCJD, Pinto AMV, Balthar MA, Correa ABA, Bhattacharyya D, Simas ABC, Kuca K, Forgione P, França TCC, Cavalcante SFA, Kitagawa DAS | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40516590/ | ||||
| DOI: | 10.1016/j.cbi.2025.111605 | ||||
| Publication: | Chemico-biological interactions | ||||
| Keywords: | Acetylcholinesterase; Alzheimer; inhibition; isatin; neurodegenerative diseases; organophosphorus; reactivators; | ||||
| PMID: | 40516590 | Category: | Date Added: | 2025-06-15 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil; Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil. Electronic address: cristina.munique@eb.mil.br. 2 Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil. Electronic address: amanda.moraes@ime.eb.br. 3 Medical Course, Souza Marques College (FSM), Rio de Janeiro, RJ, Brazil. Electronic address: marianabalthar@gmail.com. 4 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: anabeatriz.correa@eb.mil.br. 5 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada. Electronic address: dipanjan.bhattacharyya@concordia.ca. 6 Laboratory Roderick A. Barnes, Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, 21941-902, Rio de Janeiro, RJ, Brazil. Electronic address: abcsimas@ippn.ufrj.br. 7 Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic. Electronic address: kamil.kuca@uhk.cz. 8 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada. Electronic address: pat.forgione@concordia.ca. 9 Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic. Electronic address: tanos@ime.eb.br. 10 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: samir.cavalcante@eb.mil.br. 11 Agency for Management and Technological Innovation (AGITEC), Brazilian Army Department of Science and Technology, Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: kitagawa.daniel@eb.mil.br. |
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Description: |
Given the recent deployment of nerve agents as a method of warfare and in targeted assassinations, the development of robust, broad-spectrum medical countermeasures is essential. Our research group has synthesized isatin-pyridine oxime hybrids that have previously demonstrated the ability to rescue Electrophorus eel acetylcholinesterase (EeAChE) inhibited by nerve agent surrogates. In this work, we investigate the in vitro AChE inhibitory properties of these hybrids, estimating their IC50. Compounds 14 and 15 evidenced inhibitiory ability (226.4 and 24.7 µM of IC50, respectively), and this last was similar to compound reference pyridostigmine bromide, the only reported drug used as prophylactic measure for nerve agent exposure. Results suggest promisor dual-functional compounds for nerve agent prophylaxis and the reactivation of enzyme catalytic activity. |
