Keyword search (4,163 papers available)

"Antipsychotic" Keyword-tagged Publications:

Title Authors PubMed ID
1 Chronic Neuroleptic-Induced Parkinsonism Examined with Positron Emission Tomography. Galoppin M, Berroir P, Soucy JP, Suzuki Y, Lavigne GJ, Gagnon JF, Montplaisir JY, Stip E, Blanchet PJ 32353194
PERFORM
2 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
3 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
4 Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment. Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN 28522313
CSBN

 

Title:Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.
Authors:Servonnet A,  Minogianis EA,  Bouchard C,  Bédard AM,  Lévesque D,  Rompré PP,  Samaha AN
Link:https://www.ncbi.nlm.nih.gov/pubmed/28522313?dopt=Abstract
DOI:10.1016/j.neuropharm.2017.05.015
Publication:Neuropharmacology
Keywords:Amphetamine;  Antipsychotic;  Dopamine supersensitivity;  Neurotensin;  Nucleus accumbens; 
PMID:28522313 Category:Neuropharmacology Date Added:2019-06-20
Dept Affiliation: CSBN
1 Department of Neuroscience, Faculty of Medicine, Université de Montréal, Canada.
2 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Canada.
3 Faculty of Pharmacy, Université de Montréal, Canada; Central Nervous System Research Group (GRSNC), Faculty of Medicine, Université de Montréal, 2900 Edouard-Montpetit Boulevard, Montreal, H3T 1J4, Quebec, Canada.
4 Department of Neuroscience, Faculty of Medicine, Université de Montréal, Canada; FRQ-S Research Group in Behavioral Neurobiology, Concordia University, 7141 Sherbrooke Street West, Montreal, H4B 1R6, Quebec, Canada.
5 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Canada; Central Nervous System Research Group (GRSNC), Faculty of Medicine, Université de Montréal, 2900 Edouard-Montpetit Boulevard, Montreal, H3T 1J4, Quebec, Canada. Electronic address: Anna.samaha@umontreal.ca.

Description:

Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.

Neuropharmacology. 2017 Sep 01;123:10-21

Authors: Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Abstract

Long-term exposure to antipsychotics like haloperidol can increase sensitivity to dopamine agonist stimulation. This could contribute to treatment failure and increase relapse to psychosis. Chronic antipsychotic treatment elevates neurotensin levels in the nucleus accumbens (NAc), where the neuropeptide modulates dopamine function by signalling through NTS1 receptors. We hypothesized that increasing neurotensin activity in the NAc attenuates the expression of antipsychotic-induced dopamine supersensitivity, which is indicated by a potentiated psychomotor response to amphetamine. Rats received either continuous (CONT-HAL; achieved via subcutaneous osmotic minipump) or intermittent (INT-HAL; achieved via daily subcutaneous injection) haloperidol treatment for 16-17 days. Three to 5 days later, we injected neurotensin into the NAc and measured amphetamine-induced locomotion. Only CONT-HAL rats showed potentiated amphetamine-induced locomotion, indicating dopamine supersensitivity. Compared to intra-NAc saline, intra-NAc neurotensin suppressed amphetamine-induced locomotion in CONT-HAL rats, but not in INT-HAL or control rats. In a new cohort of CONT-HAL and INT-HAL rats, we measured striatal levels of proneurotensin mRNA and NTS1 receptors. The two treatments led to overlapping but also distinct neurochemical profiles. Neither treatment altered NTS1 receptor levels in the NAc, but both increased proneurotensin mRNA levels in the NAc core. In the caudate-putamen, only INT-HAL increased NTS1 receptor levels, while only CONT-HAL increased proneurotensin mRNA expression. Thus, antipsychotic-induced dopamine supersensitivity enhances the ability of neurotensin in the NAc to regulate dopamine-mediated behaviours, and this likely does not involve changes in local levels of NTS1 receptors or proneurotensin mRNA. We conclude that increasing neurotensin activity could be considered to attenuate antipsychotic-induced dopamine supersensitivity.

PMID: 28522313 [PubMed - indexed for MEDLINE]




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