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PubMed Publications| Keyword search (4,165 papers available) |  |
"Appetitive" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats | LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN; | 40341317 CSBN |
| 2 | The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression | Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD; | 36336498 PSYCHOLOGY |
| 3 | Concurrent Validity of the Adult Eating Behavior Questionnaire in a Canadian Sample | Cohen TR; Kakinami L; Plourde H; Hunot-Alexander C; Beeken RJ; | 34925181 PERFORM |
| 4 | The Role of Context Conditioning in the Reinstatement of Responding to an Alcohol-Predictive Conditioned Stimulus | LeCocq MR; Sun S; Chaudhri N; | 34852244 PSYCHOLOGY |
| 5 | Context controls the timing of responses to an alcohol-predictive conditioned stimulus. | Valyear MD, Chaudhri N | 32017964 PSYCHOLOGY |
| Title: | Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats | ||||
| Authors: | LeCocq MR, Mainville-Berthiaume A, Laplante I, Samaha AN | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40341317/ | ||||
| DOI: | 10.1093/ijnp/pyaf030 | ||||
| Publication: | The international journal of neuropsychopharmacology | ||||
| Keywords: | Appetitive; Conditioned approach; Conditioned stimulus; Pavlovian conditioning; Reinforcement; | ||||
| PMID: | 40341317 | Category: | Date Added: | 2025-05-09 | |
| Dept Affiliation: |
CSBN
1 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. 2 Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. 3 Center for Biomedical Innovation (CIB), Université de Montréal, Montréal, QC, Canada. 4 Center for Interdisciplinary Research on the Brain and Learning (CIRCA), Université de Montréal, Montréal, QC, Canada. 5 Center for Studies in Behavioural Neurobiology, Concordia University, Montréal, QC, Canada. |
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Description: |
Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which occur response-independently and signal that a seeking action will produce reward. Metabotropic group II glutamate (mGlu2/3) receptors in the basolateral amygdala (BLA) modulate CS-guided reward seeking; however, their role in DS effects is unknown. Methods: We developed a procedure to assess DS and CS effects on reward seeking in the same subjects within the same test session. Female and male rats self-administered sucrose where DSs signaled periods of sucrose availability (DS+) and unavailability (DS-). During DS+ trials, active lever presses produced sucrose paired with a CS+. During DS- trials, active lever presses produced a CS- and no sucrose. Across 14 sessions, rats learned to load up on sucrose during DS+ trials and inhibit responding during DS- trials. We then compared the effects of intra-BLA microinfusions of the mGlu2/3 receptor agonist LY379268 on cue-evoked sucrose seeking during a test where the DSs and CSs were presented response-independently, without sucrose. Before testing, rats received intra-BLA microinjections of artificial cerebrospinal fluid (aCSF) or LY379268. Results: Under aCSF, only the DS+ and DS+CS+ combined triggered increases in reward-seeking behaviour. The CS+ alone was ineffective. Intra-BLA LY379268 reduced the sucrose seeking triggered by the DS+ and DS+CS+ combination. Conclusions: Using a new procedure to test reward seeking induced by DSs and CSs, we show that BLA mGlu2/3 receptor activity mediates the conditioned incentive motivational effects of reward-predictive DSs. |
