PERFORM Publications

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Title		Authors	PubMed ID
1	Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment	Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T;	41929984 HKAP
2	Pontine Functional Connectivity Gradients	Rousseau PN; Bazin PL; Steele CJ;	41420671 SOH
3	Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles	Rattray GF; Jourde HR; Baillet S; Coffey EBJ;	41002111 PSYCHOLOGY
4	Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults	Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;	40646404 PERFORM
5	Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment	Grant N; Phillips N;	40567819 PSYCHOLOGY
6	Spectral and network investigation reveals distinct power and connectivity patterns between phasic and tonic REM sleep	Avigdor T; Peter-Derex L; Ho A; Schiller K; Wang Y; Abdallah C; Delaire E; Jaber K; Travnicek V; Grova C; Frauscher B;	40394955 SOH
7	The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies	Avigdor T; Ren G; Abdallah C; Dubeau F; Grova C; Frauscher B;	40126936 PERFORM
8	Sleep neuroimaging: Review and future directions	Pereira M; Chen X; Paltarzhytskaya A; Pache?o Y; Muller N; Bovy L; Lei X; Chen W; Ren H; Song C; Lewis LD; Dang-Vu TT; Czisch M; Picchioni D; Duyn J; Peigneux P; Tagliazucchi E; Dresler M;	39940102 HKAP
9	Human Auditory-Motor Networks Show Frequency-Specific Phase-Based Coupling in Resting-State MEG	Bedford O; Noly-Gandon A; Ara A; Wiesman AI; Albouy P; Baillet S; Penhune V; Zatorre RJ;	39757971 PSYCHOLOGY
10	Neural correlates of impulsivity in amphetamine use disorder	Kaboodvand N; Shabanpour M; Guterstam J;	38991286 ENCS
11	Connectivity preservation control for multiple unmanned aerial vehicles in the presence of bounded actuation	Xue X; Yuan B; Yi Y; Zhang Y; Yue X; Mu L;	38964998 ENCS
12	A population-averaged structural connectomic brain atlas dataset from 422 HCP-aging subjects	Xiao Y; Gilmore G; Kai J; Lau JC; Peters T; Khan AR;	37663773 ENCS
13	Mapping pontocerebellar connectivity with diffusion MRI	Rousseau PN; Chakravarty MM; Steele CJ;	36252913 PERFORM
14	Empathy, Defending, and Functional Connectivity While Witnessing Social Exclusion	McIver TA; Craig W; Bosma RL; Chiarella J; Klassen J; Sandra A; Goegan S; Booij L;	35659207 PSYCHOLOGY
15	Neurophysiological Changes Induced by Music-Supported Therapy for Recovering Upper Extremity Function after Stroke: A Case Series	Ghai S; Maso FD; Ogourtsova T; Porxas AX; Villeneuve M; Penhune V; Boudrias MH; Baillet S; Lamontagne A;	34065395 PSYCHOLOGY
16	Potential Movement Corridors and High Road-Kill Likelihood do not Spatially Coincide for Felids in Brazil: Implications for Road Mitigation.	Cerqueira RC, Leonard PB, da Silva LG, Bager A, Clevenger AP, Jaeger JAG, Grilo C	33469694 BIOLOGY
17	Arcuate fasciculus architecture is associated with individual differences in pre-attentive detection of unpredicted music changes	Vaquero L; Ramos-Escobar N; Cucurell D; François C; Putkinen V; Segura E; Huotilainen M; Penhune V; Rodríguez-Fornells A;	33454403 MLNP
18	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L	32479312 PSYCHOLOGY
19	Neural network retuning and neural predictors of learning success associated with cello training	Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ;	29891670 PSYCHOLOGY
20	Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: an initial step toward individual connectivity assessment.	Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C	25565949 PERFORM
21	SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.	Lee K, Lina JM, Gotman J, Grova C	27046111 PERFORM
22	Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.	Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM	28145075 PERFORM

Title:	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.
Authors:	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32479312?dopt=Abstract
DOI:	10.1016/j.jad.2020.03.062
Publication:	Journal of affective disorders
Keywords:	Adolescent depression; Brain structure; DNA methylation; Epigenetics; Functional connectivity;
PMID:	32479312	Category:	J Affect Disord	Date Added:	2020-06-02
Dept Affiliation:	PSYCHOLOGY 1 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. 2 Department of Psychology, Queen's University, Kingston, Canada. 3 Department of Psychology, Concordia University, Montreal, Canada. 4 Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany. 5 Department of Psychiatry, Trinity College School of Medicine and Trinity College Institute of Neuroscience, Dublin, Ireland. 6 Department of Psychology, Concordia University, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. 7 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. 8 Department of Psychiatry, Division of Child Psychiatry, Hotel Dieu Hospital, Queen's University, Kingston, Canada. 9 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. Electronic address: linda.booij@concordia.ca.

Description:

DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

J Affect Disord. 2020 Jun 15;271:160-168

Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Abstract

BACKGROUND: Studies in adult depressed patients have indicated that altered DNA methylation patterns at genes related to serotonin and HPA axis functioning (e.g., SLC6A4, FKBP5) are associated with changes in frontolimbic functional connectivity and structure. Here, we examined whether these associations can be generalized to adolescents.

METHODS: 25 adolescents with depression (Mean age = 15.72 ± 0.94 SD; 20 girls) and 20 healthy controls (Mean age = 16.05 ± 1.5 SD; 16 girls) underwent a functional and structural magnetic resonance imaging protocol, which included a resting-state assessment and measures of brain morphometry. DNA was obtained from saliva. Levels of SLC6A4 and FKBP5 methylation were determined using pyrosequencing.

RESULTS: SLC6A4 methylation was linked to amygdala-frontal operculum resting-state functional connectivity (rs-FC), regardless of diagnosis, and was differentially associated with inferior orbitofrontal gyrus (IFOG) gray matter (GM) volume in adolescents with depression and controls. Replicating and extending previous findings in adults, FKBP5 methylation was associated with IFOG GM volume in depressed and healthy adolescents, as well as orbitofrontal cortex (OFC)-rostral prefrontal cortex (RPFC) connectivity in healthy adolescents only.

LIMITATIONS: Effects of medication use or genotype cannot be ruled out. Further, the relatively small sample size and predominately female sample may limit generalizability.

CONCLUSIONS: These findings suggest that previously observed associations between SLC6A4 and FKBP5 methylation and frontolimbic processes in adult depressed patients can be in part generalized to adolescent patients. Further, findings suggest that measuring peripheral methylation at these genes deserves further attention as potential markers of typical and atypical development.

PMID: 32479312 [PubMed - as supplied by publisher]

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