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PubMed Publications| Keyword search (4,164 papers available) |  |
"Cuba" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Application of machine learning for predicting the incubation period of water droplet erosion in metals | AlHammad K; Medraj M; Tembely M; | 40612685 ENCS |
| 2 | Investigating the kinetics of marine and terrestrial organic carbon incorporation and degradation in coastal bulk sediment and water settings through isotopic lenses | Mirzaei Y; Gélinas Y; | 39117203 CHEMBIOCHEM |
| 3 | Assessing greenhouse gas emissions in Cuban agricultural soils: Implications for climate change and rice (Oryza sativa L.) production | Dar AA; Chen Z; Rodríguez-Rodríguez S; Haghighat F; González-Rosales B; | 38295640 ENCS |
| 4 | Using 13C enriched acetate in isotope labelling incubation experiments: a note of caution | Leone F; Imfeld A; Mirzaei Y; Gélinas Y; | 38097918 CHEMBIOCHEM |
| 5 | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | Slobodchikova I; Sivakumar R; Rahman MS; Vuckovic D; | 31344861 CBAMS |
| Title: | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | ||||
| Authors: | Slobodchikova I, Sivakumar R, Rahman MS, Vuckovic D | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/31344861/ | ||||
| DOI: | 10.3390/toxins11080433 | ||||
| Publication: | Toxins | ||||
| Keywords: | biomonitoring; glucuronidation; high-resolution mass spectrometry (HRMS); human; metabolism; microsomal incubation; mycotoxins; | ||||
| PMID: | 31344861 | Category: | Toxins (Basel) | Date Added: | 2019-08-07 |
| Dept Affiliation: |
CBAMS
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 2 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 3 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. 4 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. |
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Description: |
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies. |
