Keyword search (4,164 papers available)

"Drosophila" Keyword-tagged Publications:

Title Authors PubMed ID
1 Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M; 36502486
BIOLOGY
2 Empowering Melatonin Therapeutics with Drosophila Models Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; 34698120
BIOLOGY
3 Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease. Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C; 33238462
BIOLOGY
4 Drug discovery and chemical probing in Drosophila. Millet-Boureima C, Selber-Hnatiw S, Gamberi C 32551911
BIOLOGY
5 Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics. Millet-Boureima C, Chingle R, Lubell WD, Gamberi C 31635379
BIOLOGY

 

Title:Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.
Authors:Millet-Boureima CRozencwaig RPolyak FGamberi C
Link:https://www.ncbi.nlm.nih.gov/pubmed/33238462
DOI:10.3390/molecules25225477
Publication:Molecules (Basel, Switzerland)
Keywords:Drosophilalongevitymelatoninoxidative stresspolycystic kidney diseaserenal cysts
PMID:33238462 Category:Molecules Date Added:2020-11-27
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
2 BH Bioscience, Montreal, QC H3W 2L2, Canada.

Description:

Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Molecules. 2020 Nov 23; 25(22):

Authors: Millet-Boureima C, Rozencwaig R, Polyak F, Gamberi C

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.

PMID: 33238462 [PubMed - in process]





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