Keyword search (4,164 papers available)

"Drug delivery" Keyword-tagged Publications:

Title Authors PubMed ID
1 Editorial: Data-driven vaccine design for microbial-associated diseases Selvaraj G; Kaliamurthi S; Wei D; 41624882
CHEMBIOCHEM
2 Synthesis and Acidic pH-Responsive Disassembly of Dual-Location Shell-Sheddable/Core-Degradable Block Copolymer Nanoassemblies and Their Controlled Drug Delivery Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK; 41524627
CHEMBIOCHEM
3 Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization Andrade-Gagnon B; Casillas-Popova SN; Oh JK; 40614241
CHEMBIOCHEM
4 Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA He S; Singh D; Helfield B; 39850318
BIOLOGY
5 Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization Memari E; Helfield B; 38988819
BIOLOGY
6 17β-Estradiol-Loaded Exosomes for Targeted Drug Delivery in Osteoporosis: A Comparative Study of Two Loading Methods Gholami Farashah MS; Javadi M; Soleimani Rad J; Shakouri SK; Asnaashari S; Dastmalchi S; Nikzad S; Roshangar L; 38022800
BIOLOGY
7 Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux Memari E; Hui F; Yusefi H; Helfield B; 37150403
PHYSICS
8 Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide Choi M; Jazani AM; Oh JK; Noh SM; 35683912
CHEMBIOCHEM
9 Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA; 35019380
CHEMBIOCHEM
10 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
11 Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. Copp W, Pontarelli A, Wilds CJ 33506614
CHEMBIOCHEM
12 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
13 Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles. Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG 31820915
CHEMBIOCHEM
14 Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner. Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A 29080670
CSBN

 

Title:Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.
Authors:Hyland L,  Rosenbaum S,  Edwards A,  Palacios D,  Graham MD,  Pfaus JG,  Woodside B,  Abizaid A
Link:https://www.ncbi.nlm.nih.gov/pubmed/29080670?dopt=Abstract
DOI:10.1016/j.yhbeh.2017.10.012
Publication:Hormones and behavior
Keywords:Anticipation;  Ghrelin;  Ghrelin receptor antagonist;  Ghrelin receptor knock out rats;  Intracranial drug delivery;  MPOA;  Sex motivation;  VTA; 
PMID:29080670 Category:Horm Behav Date Added:2019-06-20
Dept Affiliation: CSBN
1 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
2 Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada; Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
4 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada. Electronic address: alfonso_abizaid@carleton.ca.

Description:

Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Horm Behav. 2018 01;97:56-66

Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Abstract

Ghrelin, a hormone produced primarily by the stomach, has been associated with motivational processes that include reward-seeking behaviors. In male laboratory mice, elevation of ghrelin levels enhances some aspects of sexual motivation and behavior, whereas in other experiments with male mice, rats, and other species, ghrelin treatment or food deprivation decreases sexual motivation and/or behavior. The present tested the hypothesis that stimulation of ghrelin receptors in different brain regions have opposite effects on male sexual motivation and behavior. To do this we examined appetitive and consummatory sex behaviors of male rats with a truncated ghrelin receptor (FHH-GHSRm1/Mcwi), and that of their WT (FHH) littermates. We also examined the effects of ghrelin or the ghrelin antagonist D-Lys-GHRP6 delivered into the VTA or the MPOA on appetitive and consummatory sex behaviors in male Long Evans rats. Results demonstrate that rats with a truncated ghrelin receptor, or rats that are food deprived, show deficits in anticipatory sex. Furthermore, although ghrelin does not further stimulate sex anticipation in rats when infused into the VTA, intra-VTA infusions of D-Lys-GHRP6 into the VTA further decreases in sex anticipation in food deprived rats. In contrast, ghrelin delivery into the mPOA decreased sex anticipation compared to saline or D-Lys-GHRP6 infused rats. Overall, these data suggest that ghrelin receptor signalling is important for full expression of appetitive sex behaviors. Within the VTA, ghrelin may act to enhance sex motivation, while acting on the mPOA to decrease sex motivation and promote foraging.

PMID: 29080670 [PubMed - indexed for MEDLINE]




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