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PubMed Publications| Keyword search (4,163 papers available) |  |
"Fluconazole tolerance" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species | Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y; | 38929106 BIOLOGY |
| 2 | Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections | Feng Y; Lu H; Whiteway M; Jiang Y; | 37918789 BIOLOGY |
| 3 | A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols | Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y; | 36475771 BIOLOGY |
| Title: | Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections | ||||
| Authors: | Feng Y, Lu H, Whiteway M, Jiang Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/37918789/ | ||||
| DOI: | 10.1016/j.jgar.2023.10.019 | ||||
| Publication: | Journal of global antimicrobial resistance | ||||
| Keywords: | Candida albicans; Fluconazole synergistic lethal adjuvants; Fluconazole synergistic lethal targets; Fluconazole tolerance; Invasive fungal disease; | ||||
| PMID: | 37918789 | Category: | Date Added: | 2023-11-03 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. 2 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: luhui2019@tongji.edu.cn. 3 Department of Biology, Concordia University, Montreal, QC, Canada. Electronic address: malcolm.whiteway@concordia.ca. 4 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: 19851@tongji.edu.cn. |
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Description: |
Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully explored. This review discusses the high incidence of FLC tolerance in Candida species and the importance of successfully clearing FLC tolerance in treating candidiasis. We further define and characterize FLC tolerance in C. albicans and suggest that FLC tolerance is a strategy of C. albicans response to FLC damage whose mechanism differs from FLC resistance. This review identifies global factors affecting FLC tolerance and highlights the significance of the cell membrane and cell wall integrity in FLC tolerance, guiding approaches to combat IFDs caused by Candida species. |
