Keyword search (4,164 papers available)

"Frontal cortex" Keyword-tagged Publications:

Title Authors PubMed ID
1 Progesterone and allopregnanolone facilitate excitatory synaptic transmission in the infralimbic cortex via activation of membrane progesterone receptors Rahaei N; Buynack LM; Kires L; Movasseghi Y; Chapman CA; 39722289
PSYCHOLOGY
2 Optogenetic stimulation of infralimbic cortex projections to the paraventricular thalamus attenuates context-induced renewal Brown A; Chaudhri N; 36373226
PSYCHOLOGY
3 Calcium activity is a degraded estimate of spikes Hart EE; Gardner MPH; Panayi MC; Kahnt T; Schoenbaum G; 36368324
PSYCHOLOGY
4 Corticostriatal suppression of appetitive Pavlovian conditioned responding Villaruel FR; Martins M; Chaudhri N; 34880119
PSYCHOLOGY
5 Mechanisms of higher-order learning in the amygdala Gostolupce D; Iordanova MD; Lay BPP; 34197867
PSYCHOLOGY
6 Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning. Manning EE, Bradfield LA, Iordanova MD 33035525
CSBN
7 State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis. Tremblay SA, Chapman CA, Courtemanche R 31736718
HKAP
8 Prefrontal Cortex and Multiparity in Lactation. Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD 31437474
CSBN
9 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
10 Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors. Voyer D, Lévesque D, Rompré PP 27267684
CSBN
11 Gating of the neuroendocrine stress responses by stressor salience in early lactating female rats is independent of infralimbic cortex activation and plasticity. Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD 29397787
CSBN
12 Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L 28774705
PSYCHOLOGY
13 Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L 25741267
PERFORM

 

Title:Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.
Authors:Ismaylova E,  Di Sante J,  Szyf M,  Nemoda Z,  Yu WJ,  Pomares FB,  Turecki G,  Gobbi G,  Vitaro F,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/28774705?dopt=Abstract
DOI:10.1016/j.euroneuro.2017.07.005
Publication:European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Keywords:DNA methylation;  Frontal cortex;  Functional magnetic resonance imaging;  Resilience;  Serotonin transporter; 
PMID:28774705 Category:Eur Neuropsychopharmacol Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
3 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
4 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada.
5 Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada.
6 Department of Psychiatry, McGill University, Montreal, Canada.
7 CHU Sainte-Justine Research Centre, Montreal, Canada; School of Psychoeducation, University of Montreal, Montreal, Canada.
8 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.
9 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041

Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Abstract

Early adversity can influence gene expression via epigenetic mechanisms, including DNA methylation. Peripheral tissues are essential in psychiatric epigenetics, as methylation generally cannot be assessed in the living human brain. Several magnetic resonance imaging (MRI) studies show associations of peripheral serotonin transporter gene (SLC6A4) methylation with function and/or structure of frontal-limbic circuits and brain's resting-state. Commonly used samples are derived from blood, saliva or buccal cells. However, little is known regarding which peripheral tissue is most strongly associated with human brain processes. The aim of the current study was to compare the extent of the association between peripheral SLC6A4 promoter methylation and frontal-limbic function, structure and resting-state in healthy individuals across peripheral tissues. Forty healthy prospectively-followed adults underwent anatomical, resting-state and functional MRI. Saliva-, blood- and buccal-derived DNA methylation was assessed by pyrosequencing. Blood-derived SLC6A4 methylation was positively associated with superior frontal gray matter (GM) volume and with right lateral parietal area (RLP)-frontal pole regional resting-state functional connectivity (rsFC). Saliva-derived SLC6A4 methylation was positively associated with superior frontal GM volume. Buccal-derived SLC6A4 methylation was positively associated with superior and inferior frontal and anterior cingulate cortical (ACC) GM volumes, and with RLP-ACC, frontal pole and medial prefrontal regional rsFC. Current results confirmed the relevance of peripheral methylation for frontal-limbic processes in humans. Buccal cells may be the most sensitive cell type when studying SLC6A4 promoter methylation and its associated risk for neural vulnerability and resilience for psychopathologies in which serotonin is implicated. These data should be further validated in clinical populations.

PMID: 28774705 [PubMed - indexed for MEDLINE]




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