Keyword search (4,164 papers available)

"Hippocampus" Keyword-tagged Publications:

Title Authors PubMed ID
1 Effects of early midlife ovarian removal on sleep: Polysomnography-measured cortical arousal, homeostatic drive, and spindle characteristics Brown A; Gervais NJ; Gravelsins L; O' Byrne J; Calvo N; Ramana S; Shao Z; Bernardini M; Jacobson M; Rajah MN; Einstein G; 39178647
HKAP
2 Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauthier CJ; Turner GR; Spreng RN; 38388425
PSYCHOLOGY
3 Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG; 36403510
PSYCHOLOGY
4 The role of progesterone in memory bias during spatial navigation in females Eamonn L Gomez-Perales 36165431
PSYCHOLOGY
5 Progesterone rapidly alters the use of place and response memory during spatial navigation in female rats Lacasse JM; Patel S; Bailey A; Peronace V; Brake WG; 35158200
PSYCHOLOGY
6 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM
7 Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks. Cole E, Ziadé J, Simundic A, Mumby DG 31877339
PSYCHOLOGY
8 Investigating microstructural variation in the human hippocampus using non-negative matrix factorization. Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM 31715254
PSYCHOLOGY
9 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
10 Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults. Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L 29765312
PSYCHOLOGY

 

Title:Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.
Authors:Yang AK,  Mendoza JA,  Lafferty CK,  Lacroix F,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31699294?dopt=Abstract
DOI:10.1016/j.biopsych.2019.09.007
Publication:Biological psychiatry
Keywords:Feeding behavior;  Hedonic processing;  Hippocampus;  Nucleus accumbens;  Optogenetics;  Palatability; 
PMID:31699294 Category:Biol Psychiatry Date Added:2019-11-09
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Psychology, McGill University, Montreal, Quebec, Canada.
4 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Biol Psychiatry. 2019 Sep 19;:

Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Abstract

BACKGROUND: Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown.

METHODS: Bidirectional optogenetic manipulations were targeted to the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays. Number of licks per bout of consumption was used as a measure of food palatability as it was confirmed to track sucrose concentration and subjective flavor preferences.

RESULTS: Photoinhibition of NAcSh neurons, whether general or cell-type specific, was found to alter consumption without affecting its hedonic impact. Among the principal excitatory afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability upon low-frequency photostimulation time-locked to consumption. This enhancement in palatability was independent of opioid signaling and not recapitulated by NAcSh or dopamine neuron photostimulation. We further demonstrated that vHipp input photostimulation is sufficient to condition a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

CONCLUSIONS: These results demonstrate a novel contribution of vHipp-NAcSh pathway activity to palatability that may relate to its innervation of a particular region or neuronal ensemble in the NAcSh. These findings are consistent with the evidence that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appreciation of hippocampal involvement in people's food pleasantness ratings, hunger, and weight.

PMID: 31699294 [PubMed - as supplied by publisher]




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