PERFORM Publications

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Title		Authors	PubMed ID
1	Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review	Neriya Hegade KP; Bhat RB; Packirisamy M;	40650129 ENCS
2	An Automated Single-Cell Droplet-Digital Microfluidic Platform for Monoclonal Antibody Discovery	Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC;	38441226 BIOLOGY
3	Measuring prion propagation in single bacteria elucidates a mechanism of loss	Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Yuan AH; Hilfinger A; Hochschild A; Potvin-Trottier L;	37738299 PHYSICS
4	An electrochemical aptasensor for Δ9-tetrahydrocannabinol detection in saliva on a microfluidic platform	Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC;	36549107 BIOLOGY
5	Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications	Allard P; Papazotos F; Potvin-Trottier L;	36312536 BIOLOGY
6	Microfluidics in smart packaging of foods	Pou KRJ; Raghavan V; Packirisamy M;	36192908 ENCS
7	Microfluidic Platforms for the Isolation and Detection of Exosomes: A Brief Review	Raju D; Bathini S; Badilescu S; Ghosh A; Packirisamy M;	35630197 ENCS
8	Numerical and Experimental Validation of Mixing Efficiency in Periodic Disturbance Mixers	López RR; Sánchez LM; Alazzam A; Burnier JV; Stiharu I; Nerguizian V;	34577745 ENCS
9	Magnetic particle based liquid biopsy chip for isolation of extracellular vesicles and characterization by gene amplification	Bathini S; Pakkiriswami S; Ouellette RJ; Ghosh A; Packirisamy M;	34517262 ENCS
10	Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.	Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG	33455300 CHEMBIOCHEM
11	Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.	Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG	31820915 CHEMBIOCHEM
12	One Cell, One Drop, One Click: Hybrid Microfluidics for Mammalian Single Cell Isolation.	Samlali K, Ahmadi F, Quach ABV, Soffer G, Shih SCC	32705796 BIOLOGY
13	Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.	López RR, Ocampo I, Sánchez LM, Alazzam A, Bergeron KF, Camacho-León S, Mounier C, Stiharu I, Nerguizian V	32106424 ENCS
14	Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.	Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M	31817343 ENCS
15	Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels.	Alazzam A, Al-Khaleel M, Riahi MK, Mathew B, Gawanmeh A, Nerguizian V	31394810 ENCS

Title:	Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.
Authors:	Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33455300
DOI:	10.1021/acsbiomaterials.0c00896
Publication:	ACS biomaterials science & engineering
Keywords:	directed self-assembly; drug delivery; microfluidics; nanoparticles; reduction-responsive block copolymers;
PMID:	33455300	Category:	ACS Biomater Sci Eng	Date Added:	2021-01-20
Dept Affiliation:	CHEMBIOCHEM 1 Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada. 2 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada. 3 Department of Biochemistry and Microbiology, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Description:

Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

ACS Biomater Sci Eng. 2020 Sep 14; 6(9):5069-5083

Authors: Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

Abstract

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of the physicochemical properties of GSH-responsive PNPs containing cleavable disulfide groups in two different locations (core and interface, DualM PNPs). In this paper, we employ a two-phase gas-liquid microfluidic reactor for the flow-directed manufacturing of paclitaxel-loaded or DiI-loaded DualM PNPs (PAX-PNPs or DiI-PNPs, where DiI is a fluorescent drug surrogate dye). We find that both PAX-PNPs and DiI-PNPs exhibit similar flow-tunable sizes, morphologies, and internal structures to those previously described for empty DualM PNPs. Fluorescent imaging of DiI-PNP formulations shows that microfluidic manufacturing greatly improves the homogeneity of drug dispersion within the PNP population compared to standard bulk microprecipitation. Encapsulation of PAX in DualM PNPs significantly increases its selectivity to cancerous cells, with various PAX-PNP formulations showing higher cytotoxicity against cancerous MCF-7 cells than against non-cancerous HaCaT cells, in contrast to free PAX, which showed similar cytotoxicity in the two cell lines. In addition, the characterization of DualM PNP formulations formed at various microfluidic flow rates reveals that critical figures of merit for drug delivery function-including encapsulation efficiencies, GSH-triggered release rates, rates of cell uptake, cytotoxicities, and selectivity to cancerous cells-exhibit microfluidic flow tunability that mirrors trends in PNP size. These results highlight the potential of two-phase microfluidic manufacturing for controlling both structure and drug delivery function of biological stimuli-responsive nanomedicines toward improved therapeutic outcomes.

PMID: 33455300 [PubMed - in process]

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