BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,164 papers available) |  |
"Microstructure" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Variations in perfusion detectable in advance of microstructure in white matter aging | Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ; | 40694306 PHYSICS |
| 2 | Analyses of microstructural variation in the human striatum using non-negative matrix factorization | Robert C; Patel R; Blostein N; Steele CC; Mallar Chakravarty M; | 34848302 PSYCHOLOGY |
| 3 | Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease | Xiao Y; Peters TM; Khan AR; | 34106502 PERFORM |
| 4 | Influence of Homogenization and Solution Treatments Time on the Microstructure and Hardness of Inconel 718 Fabricated by Laser Powder Bed Fusion Process. | Fayed EM, Shahriari D, Saadati M, Brailovski V, Jahazi M, Medraj M | 32516909 ENCS |
| 5 | Investigating microstructural variation in the human hippocampus using non-negative matrix factorization. | Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM | 31715254 PSYCHOLOGY |
| Title: | Analyses of microstructural variation in the human striatum using non-negative matrix factorization | ||||
| Authors: | Robert C, Patel R, Blostein N, Steele CC, Mallar Chakravarty M | ||||
| Link: | pubmed.ncbi.nlm.nih.gov/34848302/ | ||||
| DOI: | 10.1016/j.neuroimage.2021.118744 | ||||
| Publication: | NeuroImage | ||||
| Keywords: | Franctional anisotropy; Mean diffusivity; Microstructure; Multimodal; Non-negative matrix factorization; Striatum; T1w/T2w; | ||||
| PMID: | 34848302 | Category: | Date Added: | 2021-12-01 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada. Electronic address: corinne.robert@mail.mcgill.ca. 2 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada. 3 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. 4 Department of Psychology, Concordia University, Montreal, QC, Canada; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. 5 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada; Dep |
||||
Description: |
The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, and the ratio between T1- and T2-weighted structural) from the Human Connectome Project Young Adult dataset (n=329 unrelated participants, age range: 22-35, F/M: 185/144). We further explored the biological and functional relationships of this parcellation by relating our findings to motor and cognitive performance in tasks known to involve the striatum as well as demographics. We identified 5 spatially distinct striatal components, for each hemisphere. We also show the gain in component stability when using multimodal versus unimodal metrics. Our findings suggest distinct microstructural patterns in the human striatum that are largely symmetric and that relate mostly to age and sex. Our work also highlights the putative functional relevance of these striatal components to different designations based on a Neurosynth meta-analysis. |
