Keyword search (4,163 papers available)

"Network" Keyword-tagged Publications:

Title Authors PubMed ID
1 On traits matching and the modular organization of food web and occurrence networks Borzone Mas D; Scarabotti PA; Vaschetto PA; Alvarenga P; Vazquez M; Arim M; 41840807
BIOLOGY
2 Tuning Deep Learning for Predicting Aluminum Prices Under Different Sampling: Bayesian Optimization Versus Random Search Alicia Estefania Antonio Figueroa 41751647
CONCORDIA
3 Capacitive bimetallic redox cycles and ligand-to-metal charge transfer to Boost denitrification with Ni sup II /sup /Fe sup II /sup -Gallic acid phenolic networks Yu S; Jin Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J; 41707775
ENCS
4 Exploiting fluctuations in gene expression to detect causal interactions between genes Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A; 41401079
BIOLOGY
5 Distinguishing Between Healthy and Unhealthy Newborns Based on Acoustic Features and Deep Learning Neural Networks Tuned by Bayesian Optimization and Random Search Algorithm Lahmiri S; Tadj C; Gargour C; 41294952
ENCS
6 The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems Kempel A; Adamidis GC; Anadón JD; Atkinson J; Auge H; Avtzis D; Bachelot B; Bashirzadeh M; Bota JL; Classen A; Constantinou I; Crawley M; de Bellis T; Dostal P; Ebeling A; Eisenhauer N; Eldridge DJ; Encina G; Estrada C; Everingham S; Fanin N; Feng Y; Gaspar M; Gooriah L; Graff P; Montalván EG; Montalván PG; Hartke TR; Huang L; Jochum M; Kaljund K; Karmiris I; Koorem K; Korell L; Laine AL; le Provost G; Lessard JP; Liu M; Liu X; Liu Y; Llancabure J; Loïez S; Loydi A; Marrero H; Gockel S; Montoya A; Münzbergo 41080499
ENCS
7 Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles Rattray GF; Jourde HR; Baillet S; Coffey EBJ; 41002111
PSYCHOLOGY
8 Cooperative Schemes for Joint Latency and Energy Consumption Minimization in UAV-MEC Networks Cheng M; He S; Pan Y; Lin M; Zhu WP; 40942666
ENCS
9 Efficient neural encoding as revealed by bilingualism Moore C; Donhauser PW; Klein D; Byers-Heinlein K; 40828024
PSYCHOLOGY
10 Personalizing brain stimulation: continual learning for sleep spindle detection Sobral M; Jourde HR; Marjani Bajestani SE; Coffey EBJ; Beltrame G; 40609549
PSYCHOLOGY
11 PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E; 40580499
BIOLOGY
12 Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment Grant N; Phillips N; 40567819
PSYCHOLOGY
13 Distributed adaptive sliding mode control with deep recurrent neural network for cooperative robotic system in automated fiber placement Zhu N; Xie WF; 40436653
ENCS
14 CASCADE-FSL: Few-shot learning for collateral evaluation in ischemic stroke Aktar M; Tampieri D; Xiao Y; Rivaz H; Kersten-Oertel M; 40250214
ENCS
15 Parallel boosting neural network with mutual information for day-ahead solar irradiance forecasting Ahmed U; Mahmood A; Khan AR; Kuhlmann L; Alimgeer KS; Razzaq S; Aziz I; Hammad A; 40185800
PHYSICS
16 Large language models deconstruct the clinical intuition behind diagnosing autism Stanley J; Rabot E; Reddy S; Belilovsky E; Mottron L; Bzdok D; 40147442
ENCS
17 CACTUS: An open dataset and framework for automated Cardiac Assessment and Classification of Ultrasound images using deep transfer learning Elmekki H; Alagha A; Sami H; Spilkin A; Zanuttini AM; Zakeri E; Bentahar J; Kadem L; Xie WF; Pibarot P; Mizouni R; Otrok H; Singh S; Mourad A; 40107020
ENCS
18 Psychosocial Function in Mild Cognitive Impairment: Social Participation is Associated With Cognitive Performance in Multiple Domains Rehan S; Phillips NA; 39773214
CONCORDIA
19 Asymmetric autocatalytic reactions and their stationary distribution Gallinger C; Popovic L; 39679357
MATHSTATS
20 Study on the mechanism of regulating micromolar Fe utilization and promoting denitrification by guanosine monophosphate (GMP) based multi-signal functional material Hematin@Fe/GMP Hao Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J; 39657473
ENCS
21 MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle McKay MJ; Weber KA; Wesselink EO; Smith ZA; Abbott R; Anderson DB; Ashton-James CE; Atyeo J; Beach AJ; Burns J; Clarke S; Collins NJ; Coppieters MW; Cornwall J; Crawford RJ; De Martino E; Dunn AG; Eyles JP; Feng HJ; Fortin M; Franettovich Smith MM; Galloway G; Gandomkar Z; Glastras S; Henderson LA; Hides JA; Hiller CE; Hilmer SN; Hoggarth MA; Kim B; Lal N; LaPorta L; Magnussen JS; Maloney S; March L; Nackley AG; O' Leary SP; Peolsson A; Perraton Z; Pool-Goudzwaard AL; Schnitzler M; Seitz AL; Semciw AI; Sheard PW; Smith AC; Snodgrass SJ; Sullivan J; Tran V; Valentin S; Walton DM; Wishart LR; Elliott JM; 39590726
HKAP
22 Ion channel classification through machine learning and protein language model embeddings Ghazikhani H; Butler G; 39572876
ENCS
23 A protocol for trustworthy EEG decoding with neural networks Borra D; Magosso E; Ravanelli M; 39549492
ENCS
24 Position-based visual servoing of a 6-RSS parallel robot using adaptive sliding mode control Zhu N; Xie WF; Shen H; 39492316
ENCS
25 Near-optimal learning of Banach-valued, high-dimensional functions via deep neural networks Adcock B; Brugiapaglia S; Dexter N; Moraga S; 39454372
MATHSTATS
26 Deep neural network-based robotic visual servoing for satellite target tracking Ghiasvand S; Xie WF; Mohebbi A; 39440297
ENCS
27 Generalization limits of Graph Neural Networks in identity effects learning D' Inverno GA; Brugiapaglia S; Ravanelli M; 39426036
ENCS
28 Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks Abicumaran Uthamacumaran 39420135
PSYCHOLOGY
29 A Survey on Error Exponents in Distributed Hypothesis Testing: Connections with Information Theory, Interpretations, and Applications Espinosa S; Silva JF; Céspedes S; 39056958
ENCS
30 NREM sleep brain networks modulate cognitive recovery from sleep deprivation Lee K; Wang Y; Cross NE; Jegou A; Razavipour F; Pomares FB; Perrault AA; Nguyen A; Aydin Ü; Uji M; Abdallah C; Anticevic A; Frauscher B; Benali H; Dang-Vu TT; Grova C; 39005401
PERFORM
31 Modelling reindeer rut activity using on-animal acoustic recorders and machine learning Boucher AJ; Weladji RB; Holand Ø; Kumpula J; 38932958
BIOLOGY
32 Carbon based sensors for air quality monitoring networks; middle east perspective Shahid I; Shahzad MI; Tutsak E; Mahfouz MMK; Al Adba MS; Abbasi SA; Rathore HA; Asif Z; Chen Z; 38831915
ENCS
33 The impact of directed choice on the design of preventive healthcare facility network under congestion Vidyarthi N; Kuzgunkaya O; 24879402
JMSB
34 Social network dynamics, infant loss, and gut microbiota composition in female Colobus vellerosus during time periods with alpha male challenges Samartino S; Christie D; Penna A; Sicotte P; Ting N; Wikberg E; 38735025
BIOLOGY
35 The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks Alvarez MR; Alkaissi H; Rieger AM; Esber GR; Acosta ME; Stephenson SI; Maurice AV; Valencia LMR; Roman CA; Alarcon JM; 38549144
CSBN
36 Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases Zhao H; Karppi J; Mototsune O; Poshina D; Svartström J; Nguyen TTM; Vo TM; Tsang A; Master E; Tenkanen M; 38539167
CSFG
37 CosSIF: Cosine similarity-based image filtering to overcome low inter-class variation in synthetic medical image datasets Islam M; Zunair H; Mohammed N; 38492455
ENCS
38 Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL; 38460310
CHEMBIOCHEM
39 A network approach to subjective cognitive decline: Exploring multivariate relationships in neuropsychological test performance across Alzheimer's disease risk states Grunden N; Phillips NA; ; 38458017
PSYCHOLOGY
40 The role of frailty in the relationships between social relationships and health outcomes: a longitudinal study Fereshteh Mehrabi 38402184
PSYCHOLOGY
41 SCANED: Siamese collateral assessment network for evaluation of collaterals from ischemic damage Aktar M; Xiao Y; Tehrani AKZ; Tampieri D; Rivaz H; Kersten-Oertel M; 38364600
ENCS
42 Variation the in relationship between urban tree canopy and air temperature reduction under a range of daily weather conditions Locke DH; Baker M; Alonzo M; Yang Y; Ziter CD; Murphy-Dunning C; O' Neil-Dunne JPM; 38352758
BIOLOGY
43 Reciprocal inhibition and competitive hierarchy cause negative biodiversity-ecosystem function relationships D' Andrea R; Khattar G; Koffel T; Frans VF; Bittleston LS; Cuellar-Gempeler C; 38193391
BIOLOGY
44 Heterogeneous dispersal networks to improve biodiversity science Savary P; Lessard JP; Peres-Neto PR; 37891075
BIOLOGY
45 Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks Ghazikhani H; Butler G; 37497772
ENCS
46 Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease Nayak SS; Naidu A; Sudhakaran SL; Vino S; Selvaraj G; 37109050
CHEMBIOCHEM
47 Decoupled responses of biodiversity facets driven from anuran vulnerability to climate and land-use changes Ceron K; Sales LP; Santana DJ; Pires MM; 36967645
BIOLOGY
48 Energy scheduling for DoS attack over multi-hop networks: Deep reinforcement learning approach Yang L; Tao J; Liu YH; Xu Y; Su CY; 36848827
ENCS
49 Dense Sampling Approaches for Psychiatry Research: Combining Scanners and Smartphones McGowan AL; Sayed F; Boyd ZM; Jovanova M; Kang Y; Speer ME; Cosme D; Mucha PJ; Ochsner KN; Bassett DS; Falk EB; Lydon-Staley DM; 36797176
PSYCHOLOGY
50 Compatible-domain Transfer Learning for Breast Cancer Classification with Limited Annotated Data Shamshiri MA; Krzyzak A; Kowal M; Korbicz J; 36758326
ENCS
51 Designing a multi-objective closed-loop supply chain: a two-stage stochastic programming, method applied to the garment industry in Montréal, Canada Shafiee Roudbari E; Fatemi Ghomi SMT; Eicker U; 36747987
ENCS
52 Mutualistic coevolution and community diversity favour persistence in metacommunities under environmental changes Cosmo LG; Sales LP; Guimarães PR; Pires MM; 36629106
BIOLOGY
53 The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum Li J; Chroumpi T; Garrigues S; Kun RS; Meng J; Salazar-Cerezo S; Aguilar-Pontes MV; Zhang Y; Tejomurthula S; Lipzen A; Ng V; Clendinen CS; Tolic N; Grigoriev IV; Tsang A; Mäkelä MR; Snel B; Peng M; de Vries RP; 36547648
BIOLOGY
54 Neural correlates of recall and extinction in a rat model of appetitive Pavlovian conditioning Brown A; Villaruel FR; Chaudhri N; 36496079
PSYCHOLOGY
55 Reinforcement learning for automatic quadrilateral mesh generation: A soft actor-critic approach Pan J; Huang J; Cheng G; Zeng Y; 36375347
ENCS
56 Cancer Survivors' Evolving Perceptions of a New Supportive Virtual Program Robb A; Brown TL; Durand A; Loiselle CG; 36354724
PSYCHOLOGY
57 Robust landmark-based brain shift correction with a Siamese neural network in ultrasound-guided brain tumor resection Pirhadi A; Salari S; Ahmad MO; Rivaz H; Xiao Y; 36306056
PERFORM
58 A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT; 35972285
BIOLOGY
59 A Review of Mathematical and Computational Methods in Cancer Dynamics Uthamacumaran A; Zenil H; 35957879
PHYSICS
60 Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics Abicumaran Uthamacumaran 35678918
PHYSICS
61 Algorithmic reconstruction of glioblastoma network complexity Uthamacumaran A; Craig M; 35479408
PHYSICS
62 Dynamic and Reprocessable Fluorinated Poly(hindered urea) Network Materials Containing Ionic Liquids to Enhance Triboelectric Performance Nellepalli P; Kim MP; Park J; Noh SM; Ye Z; Jung HW; Ko H; Oh JK; 35385641
CHEMBIOCHEM
63 Effects of Transcranial Direct Current Stimulation on Attentional Bias to Methamphetamine Cues and Its Association With EEG-Derived Functional Brain Network Topology Khajehpour H; Parvaz MA; Kouti M; Hosseini Rafsanjani T; Ekhtiari H; Bakht S; Noroozi A; Makkiabadi B; Mahmoodi M; 35380672
PERFORM
64 Structural brain network topological alterations in stuttering adults Gracco VL; Sares AG; Koirala N; 35368614
PSYCHOLOGY
65 Sentiment Classification Method Based on Blending of Emoticons and Short Texts Zou H; Xiang K; 35327909
ENCS
66 Analysis of input set characteristics and variances on k-fold cross validation for a Recurrent Neural Network model on waste disposal rate estimation Vu HL; Ng KTW; Richter A; An C; 35287077
ENCS
67 Celebrity Couples as Business Families: A Social Network Perspective Gorji Y; Carney M; Prakash R; 34931108
CONCORDIA
68 Comment on the article "Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome 486 (2020) 110102" Arsalan Rahimabadi 34843739
PERFORM
69 Comparative Evaluation of Artificial Neural Networks and Data Analysis in Predicting Liposome Size in a Periodic Disturbance Micromixer Ocampo I; López RR; Camacho-León S; Nerguizian V; Stiharu I; 34683215
ENCS
70 Dynamic Covalent Polyurethane Network Materials: Synthesis and Self-healability Nellepalli P; Patel T; Oh JK; 34418209
CHEMBIOCHEM
71 Sharp U-Net: Depthwise convolutional network for biomedical image segmentation Zunair H; Ben Hamza A; 34348214
ENCS
72 Personal Social Networks and Adiposity in Adolescents: A Feasibility Study Ybarra M; Barnett TA; Yu J; Van Hulst A; Drouin O; Kakinami L; Saint-Charles J; Henderson M; 34264758
MATHSTATS
73 COVID-FACT: A Fully-Automated Capsule Network-Based Framework for Identification of COVID-19 Cases from Chest CT Scans Heidarian S; Afshar P; Enshaei N; Naderkhani F; Rafiee MJ; Babaki Fard F; Samimi K; Atashzar SF; Oikonomou A; Plataniotis KN; Mohammadi A; 34113843
ENCS
74 Clustering of Unhealthy Behaviors: Protocol for a Multiple Behavior Analysis of Data From the Canadian Longitudinal Study on Aging van Allen Z; Bacon SL; Bernard P; Brown H; Desroches S; Kastner M; Lavoie K; Marques M; McCleary N; Straus S; Taljaard M; Thavorn K; Tomasone JR; Presseau J; 34114962
HKAP
75 Corrigendum: Deep Learning-Based Haptic Guidance for Surgical Skills Transfer Fekri P; Dargahi J; Zadeh M; 34026860
ENCS
76 Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches Selvaraj G; Kaliamurthi S; Peslherbe GH; Wei DQ; 33968364
CERMM
77 X-Vectors: New Quantitative Biomarkers for Early Parkinson's Disease Detection From Speech Jeancolas L; Petrovska-Delacrétaz D; Mangone G; Benkelfat BE; Corvol JC; Vidailhet M; Lehéricy S; Benali H; 33679361
PERFORM
78 Deep Learning-Based Haptic Guidance for Surgical Skills Transfer. Fekri P, Dargahi J, Zadeh M 33553246
ENCS
79 Using Models to (Re-)Design Synthetic Circuits. McCallum G, Potvin-Trottier L 33405217
BIOLOGY
80 Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E 33401137
PERFORM
81 Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat. Lévesque M; Gao H; Southward C; Langlois JMP; Léna C; Courtemanche R; 33240052
HKAP
82 The Epistemology of Evolutionary Psychology Offers a Rapprochement to Cultural Psychology Gad Saad 33224071
JMSB
83 COVID-CAPS: A Capsule Network-based Framework for Identification of COVID-19 cases from X-ray Images. Afshar P, Heidarian S, Naderkhani F, Oikonomou A, Plataniotis KN, Mohammadi A 32958971
ENCS
84 What Media Helps, What Media Hurts: A Mixed Methods Survey Study of Coping with COVID-19 Using the Media Repertoire Framework and the Appraisal Theory of Stress Pahayahay A; Khalili-Mahani N; 32701459
PERFORM
85 Second Opinions: Negotiating Agency in Online Mothering Forums. Aston M, Price S, Hunter A, Sim M, Etowa J, Monaghan J, Paynter M 32757828
CONCORDIA
86 BENIN: Biologically enhanced network inference. Wonkap SK, Butler G 32698722
ENCS
87 Metabolic networks of the human gut microbiota. Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhein NJ, Aprikian S, Arshad R, Azuelos JD, Bernadotte D, Beswick N, Chazbey H, Church K, Ciubotaru E, D'Amato L, Del Corpo T, Deng J, Di Giulio BL, Diveeva D, Elahie E, Frank JGM, Furze E, Garner R, Gibbs V, Goldberg-Hall R, Goldman CJ, Goltsios FF, Gorjipour K, Grant T, Greco B, Guliyev N, Habrich A, Hyland H, Ibrahim N, Iozzo T, Jawaheer-Fenaoui A, Jaworski JJ, Jhajj MK, Jones J, Joyette R, Kaudeer S, Kelley S, Ki 31799915
BIOLOGY
88 Maternal Knowing and Social Networks: Understanding First-Time Mothers' Search for Information and Support Through Online and Offline Social Networks. Price SL, Aston M, Monaghan J, Sim M, Tomblin Murphy G, Etowa J, Pickles M, Hunter A, Little V 29281945
CONCORDIA
89 Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment Malkawi AK; Masood A; Shinwari Z; Jacob M; Benabdelkamel H; Matic G; Almuhanna F; Dasouki M; Alaiya AA; Rahman AMA; 31247941
CHEMBIOCHEM
90 Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults. Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L 29765312
PSYCHOLOGY
91 Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy. Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C 30094158
PERFORM
92 Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in Patients with Persistent Insomnia Symptoms. Suh S, Kim H, Dang-Vu TT, Joo E, Shin C 26414892
PERFORM
93 Posterior dopamine D2/3 receptors and brain network functional connectivity. Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C 28700819
PERFORM
94 To Each Stress Its Own Screen: A Cross-Sectional Survey of the Patterns of Stress and Various Screen Uses in Relation to Self-Admitted Screen Addiction Khalili-Mahani N; Smyrnova A; Kakinami L; 30938685
PERFORM

 

Title:Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.
Authors:Lee KKhoo HMLina JMDubeau FGotman JGrova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/30094158?dopt=Abstract
DOI:10.1016/j.nicl.2018.06.029
Publication:NeuroImage. Clinical
Keywords:Connector hubMesial temporal lobe epilepsyNetwork regularizationResting state fMRISparse dictionary learning
PMID:30094158 Category:Neuroimage Clin Date Added:2019-06-04
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada. Electronic address: kangjoo.lee@mail.mcgill.ca.
2 Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada; Department of Neurosurgery, Osaka University, 2-2 Yamadaoka, Suita, Osaka Prefecture, 565-0871, Japan.
3 École de Technologie Supérieure, 1100 Rue Notre-Dame O, Montreal, QC H3C 1K3, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Montreal, QC H3T 1J4, Canada.
4 Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
5 Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Montreal, QC H3T 1J4, Canada; Department of Physics and PERFORM Centre, Concordia University, 7200 Rue Sherbrooke St. W, Montreal, QC H4B 1R6, Canada.

Description:

Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Neuroimage Clin. 2018;20:71-84

Authors: Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Abstract

Hubs of brain networks are brain regions exhibiting denser connections than others, promoting long-range communication. Studies suggested the reorganization of hubs in epilepsy. The patterns of connector hub abnormalities specific to mesial temporal lobe epilepsy (mTLE) are unclear. We wish to quantify connector hub abnormalities in mTLE and identify epilepsy-related resting state networks involving abnormal connector hubs. A recently developed sparsity-based analysis of reliable k-hubness (SPARK) allowed us to address this question by using resting state functional MRI in 20 mTLE patients and 17 healthy controls. Handling the multicollinearity of functional networks, SPARK measures a new metric of hubness by counting the number (k) of networks involved in each voxel, and identifies which networks are actually associated to each connector hub. This measure provides new information about the network architecture involving connector hubs and a realistic range of k-hubness. We quantified the disruption and emergence of connector hubs in individual epileptic subjects and assessed the lateralization of networks involving connector hubs. In mTLE, we found pathological disruptions of normal connector hubs in the mTL and within the default mode network. Right mTLE had remarkably higher emergence of new connector hubs in the mTL than left mTLE. Different patterns of lateralization of the salience network involving the abnormal hippocampus were found in right versus left mTLE. The temporal, cerebellar, default mode, subcortical and motor networks also contributed to the lateralization of hippocampal networks. We finally observed an asymmetrical connector hub reorganization and overall regularization of epilepsy-related resting state networks in mTLE, characterized by the disruption of distant connections and the emergence of local connections.

PMID: 30094158 [PubMed - indexed for MEDLINE]





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