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PubMed Publications| Keyword search (4,163 papers available) |  |
"Neurodegenerative disease" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Exploring neurologists perspectives: barriers and facilitators in implementing cognitive care planning | Ge S; Xiao X; Huang B; Britt KC; | 41163714 CONCORDIA |
| 2 | In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis | Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS; | 40516590 CHEMBIOCHEM |
| 3 | Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders | Eskandari K; Bélanger SM; Lachance V; Kourrich S; | 40430519 CSBN |
| 4 | Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities | Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM; | 39364217 PSYCHOLOGY |
| 5 | Measures of motor segmentation from rapid isometric force pulses are reliable and differentiate Parkinson's disease from age-related slowing | Howard SL; Grenet D; Bellumori M; Knight CA; | 35768733 PSYCHOLOGY |
| 6 | Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study. | Pieruccini-Faria F, Black SE, Masellis M, Smith EE, Almeida QJ, Li KZH, Bherer L, Camicioli R, Montero-Odasso M | 33590967 PSYCHOLOGY |
| 7 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| Title: | Measures of motor segmentation from rapid isometric force pulses are reliable and differentiate Parkinson's disease from age-related slowing | ||||
| Authors: | Howard SL, Grenet D, Bellumori M, Knight CA | ||||
| Link: | pubmed.ncbi.nlm.nih.gov/35768733/ | ||||
| DOI: | 10.1007/s00221-022-06398-4 | ||||
| Publication: | Experimental brain research | ||||
| Keywords: | Bradykinesia; Motor segmentation; Muscle; Neurodegenerative disease; Parkinson'; s disease; Rate of force development; | ||||
| PMID: | 35768733 | Category: | Date Added: | 2022-06-30 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Dept. of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA. 2 Department of Psychology, Concordia University, Montreal, QC, Canada. 3 Kinesiology Department, California State University, Monterey Bay, Seaside, CA, USA. 4 Department of Kinesiology and Applied Physiology, University of Delaware, 344 The Tower at STAR, 100 Discovery Blvd., Newark, DE, 19716, USA. caknight@udel.edu. |
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Description: |
Some people with Parkinson's disease (PD) have disruptions in motor output during rapid isometric muscle contractions. Measures of such disruptions (motor segmentation) may help clarify disease subtype, progression, or effects of therapeutic interventions. We investigated the potential utility of segmentation measures by testing two hypotheses that are fundamental to measurement and evaluation. First, measures of motor segmentation are reliable from day to day (intraclass correlation coefficient > 0.8). Second, that measures of motor segmentation have the sensitivity to differentiate between people with PD and older adults. 10 subjects with PD had a mean age of 70.1 years, Hoehn-Yahr stage < 3, and median levodopa equivalent daily dose of 350 mg. Older adult (mean age 81.9 years) reference data are from a previously published study. Each subject provided approximately 87 rapid isometric index finger abduction force pulses up to 65% of their maximal isometric force for calculation of force pulse measures. Measures were computed for the excitation, transition, and relaxation phases of each force pulse. Measures of motor segmentation had high reliability and presented large (Cohen's D > 0.8) and significant (p < 0.05) group differences. In bivariate plots of selected measures, motor segmentation marked a departure of PD from age-related slowing. Across all subjects, greater segmentation was associated with greater impairments in rate control and a longer time to reach peak force (all Spearman's ? > 0.8). These results support the potential utility of the motor segmentation measures by satisfying requirements for reliability and the sensitivity to indicate deviations from age-related slowing in motor output. |
