PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in em Caenorhabditis elegans, /em challenges a proposed role in heme trafficking	Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;	41504601 BIOLOGY
2	Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex	Olajide OJ; Batallán Burrowes AA; da Silva IF; Bergdahl A; Chapman CA;	39617168 HKAP
3	Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium	Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;	39303770 PSYCHOLOGY
4	A systematic review and meta-analysis of randomized controlled trials investigating the effects of probiotics on oxidative stress in healthy adults	St-Amant A; Bergdahl A;	36963861 HKAP
5	Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex	Olajide OJ; La Rue C; Bergdahl A; Chapman CA;	36275011 HKAP
6	Zinc Homeostasis in Diabetes Mellitus and Vascular Complications	MacKenzie S; Bergdahl A;	35052818 HKAP
7	Empowering Melatonin Therapeutics with Drosophila Models	Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C;	34698120 BIOLOGY
8	Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero	Olajide OJ; Alliy ZO; Ojo DO; Osinubi OO; Bello SO; Ibrahim FE; Adukwu FO; Abikoye TO; Gbadamosi IT; Mutholib NY; Bamisi O; Ajiboye OJ; Okesina AA; Alli-Oluwafuyi A; Oyewole AL; Nafiu AB; Akinola O;	33845156 PSYCHOLOGY
9	Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.	Olajide OJ, Suvanto ME, Chapman CA	33495355 PSYCHOLOGY
10	Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.	Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;	33238462 BIOLOGY
11	Inhibitory potentials of Cymbopogon citratus oil against aluminium-induced behavioral deficits and neuropathology in rats.	Temitayo GI, Olawande B, Emmanuel YO, Timothy AT, Kehinde O, Susan LF, Ezra L, Joseph OO	32839358 PSYCHOLOGY
12	Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.	Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI	25839782 MASSSPEC

Title:	Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.
Authors:	Millet-Boureima C, Rozencwaig R, Polyak F, Gamberi C
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33238462
DOI:	10.3390/molecules25225477
Publication:	Molecules (Basel, Switzerland)
Keywords:	Drosophila; longevity; melatonin; oxidative stress; polycystic kidney disease; renal cysts;
PMID:	33238462	Category:	Molecules	Date Added:	2020-11-27
Dept Affiliation:	BIOLOGY 1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 BH Bioscience, Montreal, QC H3W 2L2, Canada.

Description:

Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Molecules. 2020 Nov 23; 25(22):

Authors: Millet-Boureima C, Rozencwaig R, Polyak F, Gamberi C

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.

PMID: 33238462 [PubMed - in process]

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