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"Psychiatry" Keyword-tagged Publications:

Title Authors PubMed ID
1 The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial McAnulty C; Lavoie P; Cyr S; Lavin P; Elkrief L; Richard-Devantoy S; Rizkallah E; Lespérance P; Gamin N; Lembke A; Jutras-Aswad D; Greenway K; Garel N; 41857871
PSYCHOLOGY
2 Large language models deconstruct the clinical intuition behind diagnosing autism Stanley J; Rabot E; Reddy S; Belilovsky E; Mottron L; Bzdok D; 40147442
ENCS
3 Effect of mindfulness-based programmes on elite athlete mental health: a systematic review and meta-analysis Myall K; Montero-Marin J; Gorczynski P; Kajee N; Syed Sheriff R; Bernard R; Harriss E; Kuyken W; 36223914
EDUCATION
4 Depression Screening and Health Outcomes in Children and Adolescents: A Systematic Review Roseman M; Saadat N; Riehm KE; Kloda LA; Boruff J; Ickowicz A; Baltzer F; Katz LY; Patten SB; Rousseau C; Thombs BD; 28851234
LIBRARY
5 Striking a balance: triage and crisis intervention models within the pediatric emergency room Laporte N; Hechtman L; Rousseau C; Greenfield B; 37920538
PSYCHOLOGY
6 Teleconsultations for mental health: Recommendations from a Delphi panel Manera V; Partos C; Beauchet O; Benoit M; Dupetit B; Elbaum J; Fabre R; Gindt M; Gros A; Guerchouche R; Klöppel S; König A; Martin A; Mouton A; Pancrazi MP; Politis A; Robert G; Sacco G; Sacconi S; Sawchuk K; Solari F; Thiebot L; Trimarchi PD; Zeghari R; Robert P; 37655117
ENCS
7 Gender and sex in eating disorders: A narrative review of the current state of knowledge, research gaps, and recommendations Breton É; Juster RP; Booij L; 36840375
PSYCHOLOGY
8 Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review. Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L; 33221025
PSYCHOLOGY
9 Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis Thombs BD; Levis B; Lyubenova A; Neupane D; Negeri Z; Wu Y; Sun Y; He C; Krishnan A; Vigod SN; Bhandari PM; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Barnes J; Beck CT; Bindt C; Figueiredo B; Helle N; Howard LM; Kohlhoff J; Kozinszky Z; Leonardou AA; Radoš SN; Quispel C; Rochat TJ; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; 33104415
LIBRARY

 

Title:The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial
Authors:McAnulty CLavoie PCyr SLavin PElkrief LRichard-Devantoy SRizkallah ELespérance PGamin NLembke AJutras-Aswad DGreenway KGarel N
Link:https://pubmed.ncbi.nlm.nih.gov/41857871/
DOI:10.1136/bmjopen-2026-116969
Publication:BMJ open
Keywords:Depression &mood disordersFeasibility StudiesPSYCHIATRYSubstance misuse
PMID:41857871 Category: Date Added:2026-03-20
Dept Affiliation: PSYCHOLOGY
1 Research Centre, Centre Hospitalier de l'Universite de Montreal, Montreal, Québec, Canada.
2 Department of Psychiatry and Addictology, Université de Montréal, Montreal, Québec, Canada.
3 Department of Psychology, Concordia University, Montreal, Québec, Canada.
4 McGill Group for Suicide Studies, McGill University & Douglas Mental Health Research Institute, Montreal, Québec, Canada.
5 CISSS des Laurentides, Saint-Jérôme, Québec, Canada.
6 Department of Mental Health, Quatuor MD, Montreal, Québec, Canada.
7 Department of Psychology, Université de Sherbooke, Sherbrooke, Québec, Canada.
8 Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
9 Centre de recherche, Centre Hospitalier de l'Universite de Montreal, Montreal, Québec, Canada.
10 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada.
11 Department of Psychiatry, McGill University, Montreal, Québec, Canada.
12 Research Centre, Centre Hospitalier de l'Universite de Montreal, Montreal, Québec, Canada nicolas.garel@umontreal.ca.
13 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.

Description:

Background: Alcohol use disorder and treatment-resistant depression (TRD) often co-occur, presenting a major clinical challenge with limited effective treatments. However, ketamine produces rapid antidepressant effects and has shown promise in reducing alcohol use, and acceptance and commitment therapy (ACT) can be effective for both substance use and mood disorders. This study explores the feasibility and acceptability of combining ACT with ketamine within the framework of the Montreal Model-a structured, integrative psychedelic ketamine therapy developed for severe TRD.

Methods and analysis: This study is a single-group, open-label feasibility trial at the Centre hospitalier de l'Université de Montréal (CHUM) Neuromodulation Ketamine Clinic in Montreal, Canada. 30 participants diagnosed with both alcohol use disorder and treatment-resistant depression will receive eight weekly in-person or virtual ACT sessions in addition to six intravenous ketamine infusions. The primary outcome is feasibility, assessed through study completion and protocol adherence. Secondary outcomes include recruitment rate, tolerability, safety, data completeness and healthcare resource use. Exploratory measures will examine changes in depressive symptoms, alcohol use and quality of life using validated tools. A subset of participants will participate in semistructured qualitative interviews to explore their experiences.

Ethics and dissemination: This study was approved by the ethics committee of the CHUM on 14 May 2025. The results of the trial, including primary and secondary outcomes, will be published in peer-reviewed scientific journals.

Trial registration number: NCT06620276.





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