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PubMed Publications| Keyword search (4,163 papers available) |  |
"Randomized controlled trial" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial | Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC; | 41795685 HKAP |
| 2 | A randomized controlled trial of an acceptance-based, insight-inducing medication adherence therapy (AIM-AT) for adults with early-stage psychosis | Chien WT; Chong YY; Bressington D; McMaster CW; | 38908265 CONCORDIA |
| 3 | An international, Delphi consensus study to identify priorities for methodological research in behavioral trials in health research. | Byrne M, McSharry J, Meade O, Lavoie KL, Bacon SL | 32293510 HKAP |
| 4 | Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar | Thombs BD; Levis AW; Azar M; Saadat N; Riehm KE; Sanchez TA; Chiovitti MJ; Rice DB; Levis B; Fedoruk C; Lyubenova A; Malo Vázquez de Lara AL; Kloda LA; Benedetti A; Shrier I; Platt RW; Kimmelman J; | 31866472 LIBRARY |
| Title: | Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial | ||||
| Authors: | Liu-Ambrose T, Falck RS, Dao E, Crockett RA, Barha CK, Silva NCBS, Alkeridy WA, Best JR, Hsiung GR, Field TS, Madden KM, Davis JC, Ten Brinke LF, Tam RC | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41795685/ | ||||
| DOI: | 10.1002/alz.71245 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | mild cognitive impairment; progressive resistance training; randomized controlled trial; vascular cognitive impairment; | ||||
| PMID: | 41795685 | Category: | Date Added: | 2026-03-08 | |
| Dept Affiliation: |
HKAP
1 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada. 2 Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. 3 Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada. 4 School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada. 5 Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. 6 International Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada. 7 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. 8 Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary,Calgary, Alberta, Canada. 9 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montréal, Québec, Canada. 10 Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada. 11 Department of Medicine, King Saud University, College of Medicine, Riyadh, Saudi Arabia. 12 Department of Medicine, Division of Geriatric Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 13 Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. 14 Vancouver Stroke Program, Vancouver, British Columbia, Canada. 15 Faculty of Management, University of British Columbia-Okanagan, British Columbia, Kelowna, Canada. |
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Description: |
Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing PRT versus balance and tone exercises (BAT) on the Alzheimer's Disease Assessment Scale Cognitive Plus (ADAS-Cog-Plus). Results: Ninety-one participants were randomized (PRT = 45; BAT = 46); 76 completed the trial. Adherence was not different between groups (p = 0.18). At 12 months, PRT significantly improved ADAS-Cog-Plus scores (estimated mean difference: -0.18; 95% confidence interval [CI: -0.35, -0.01]; p = 0.04). Planned contrasts stratified by sex showed a significant PRT effect on ADAS-Cog-Plus scores for females (mean difference: -0.27; 95% CI: [-0.49, -0.05]; p = 0.02), but not for males. PRT also significantly reduced C-reactive protein (estimated mean difference: -2.93; 95% CI: [-5.36, -0.49]; p = 0.02). No significant differences were observed for other secondary outcomes. Discussion: PRT may have a small beneficial effect on cognitive function in SVCI. Clinical trial registration: This trial was registered with ClinicalTrials.gov (NCT02669394). |
