Keyword search (4,164 papers available)

"Sex differences" Keyword-tagged Publications:

Title Authors PubMed ID
1 Biological sex and bilingualism: Its impact on risk and resilience for dementia Calvo N; Phillips N; Bialystok E; Einstein G; 41573422
PSYCHOLOGY
2 Contextual use of male-male social information by Trinidadian guppies Brusseau AJP; Dumaresq-Synnott F; Morris J; Nagl AC; Ramnarine IW; Crane AL; Brown GE; 41460359
BIOLOGY
3 Antipredator decisions of male Trinidadian guppies ( em Poecilia reticulata /em ) depend on social cues from females Brusseau AJP; Feyten LEA; Crane AL; Ramnarine IW; Ferrari MCO; Brown GE; 40264715
BIOLOGY
4 Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; 40086421
PSYCHOLOGY
5 Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans Costa DN; Santosa S; Jensen MD; 39869194
SOH
6 Learning processes in relapse to alcohol use: lessons from animal models Valyear MD; LeCocq MR; Brown A; Villaruel FR; Segal D; Chaudhri N; 36264342
PSYCHOLOGY
7 Sexually dimorphic role of circadian clock genes in alcohol drinking behavior Nuria de Zavalia 36184679
PSYCHOLOGY
8 Supplementary dataset of context-dependent conditioned responding to an alcohol-predictive cue in female and male rats Segal D; Valyear MD; Chaudhri N; 35330738
PSYCHOLOGY
9 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women Gagne C; Piot A; Brake WG; 35115970
CSBN
10 Profiles of Anxious and Depressive Symptoms Among Adolescent Boys and Girls: Associations with Coping Strategies Olivier E; Morin AJS; Tardif-Grenier K; Archambault I; Dupéré V; Hébert C; 35038084
CONCORDIA
11 The role of context on responding to an alcohol-predictive cue in female and male rats Segal D; Valyear MD; Chaudhri N; 34742865
PSYCHOLOGY
12 The Biology of Vasopressin. Sparapani S, Millet-Boureima C, Oliver J, Mu K, Hadavi P, Kalostian T, Ali N, Avelar CM, Bardies M, Barrow B, Benedikt M, Biancardi G, Bindra R, Bui L, Chihab Z, Cossitt A, Costa J, Daigneault T, Dault J, Davidson I, Dias J, Dufour E, El-Khoury S, Farhangdoost N, Forget A, Fox A, Gebrael M, Gentile MC, Geraci O, Gnanapragasam A, Gomah E, Haber E, Hamel C, Iyanker T, Kalantzis C, Kamali S, Kassardjian E, Kontos HK, Le TBU, LoScerbo D, Low YF, Mac Rae D, Maurer F, Mazhar S, Nguyen A, Nguyen-Duong K, Osborne-L 33477721
BIOLOGY
13 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM
14 Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study. D'Amico D, Parrott MD, Greenwood CE, Ferland G, Gaudreau P, Belleville S, Laurin D, Anderson ND, Kergoat MJ, Morais JA, Presse N, Fiocco AJ, 32563260
PERFORM

 

Title:Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Authors:Tamming RJDumeaux VJiang YShafiq SLanglois LEllegood JQiu LRLerch JPBérubé NG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32610139?dopt=Abstract
DOI:10.1016/j.celrep.2020.107838
Publication:Cell reports
Keywords:ATRXH3K27me3chromatinhippocampusintellectual disabilitylong-term spatial memorymiR-137presynaptic vesiclessex differencessynapse
PMID:32610139 Category:Cell Rep Date Added:2020-07-02
Dept Affiliation: PERFORM
1 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada.
2 Department of Paediatrics, Western University, London, ON, Canada; PERFORM Centre, Concordia University, Montreal, QC, Canada.
3 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada.
4 Children's Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
5 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
6 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
7 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
8 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
9 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: nberube@uwo.ca.

Description:

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Cell Rep. 2020 Jun 30;31(13):107838

Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Abstract

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deletion of neuronal Atrx in mice leads to distinct hippocampal structural defects, fewer presynaptic vesicles, and an enlarged postsynaptic area at CA1 apical dendrite-axon junctions. We identify male-specific impairments in long-term contextual memory and in synaptic gene expression, linked to altered miR-137 levels. We show that ATRX directly binds to the miR-137 locus and that the enrichment of the suppressive histone mark H3K27me3 is significantly reduced upon the loss of ATRX. We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction.

PMID: 32610139 [PubMed - as supplied by publisher]





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