BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,163 papers available) |  |
"Source imaging" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | Heers M; Afnan J; Braun C; Grova C; Altenmüller DM; Steinhoff BJ; Dümpelmann M; Demerath T; Urbach H; Ethofer S; Siegel M; Schulze-Bonhage A; Lerche H; Li Hegner Y; | 41804684 PERFORM |
| 2 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 3 | EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy | Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C; | 38994740 SOH |
| 4 | Dynamic networks differentiate the language ability of children with cochlear implants | Koirala N; Deroche MLD; Wolfe J; Neumann S; Bien AG; Doan D; Goldbeck M; Muthuraman M; Gracco VL; | 37409105 PSYCHOLOGY |
| 5 | Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas | Afnan J; von Ellenrieder N; Lina JM; Pellegrino G; Arcara G; Cai Z; Hedrich T; Abdallah C; Khajehpour H; Frauscher B; Gotman J; Grova C; | 37149236 PERFORM |
| 6 | Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy | Frauscher B; Bénar CG; Engel JJ; Grova C; Jacobs J; Kahane P; Wiebe S; Zjilmans M; Dubeau F; | 37119580 PERFORM |
| 7 | Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography. | Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B | 33450578 PERFORM |
| 8 | Source imaging of deep-brain activity using the regional spatiotemporal Kalman filter | Hamid L; Habboush N; Stern P; Japaridze N; Aydin Ü; Wolters CH; Claussen JC; Heute U; Stephani U; Galka A; Siniatchkin M; | 33250282 PERFORM |
| 9 | Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients | Pellegrino G, Xu M, Alkuwaiti A, Porras-Bettancourt M, Abbas G, Lina JM, Grova C, Kobayashi E, | 32582009 PERFORM |
| 10 | Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients. | Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E | 32386115 PERFORM |
| 11 | Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy. | Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E | 25609211 PERFORM |
| 12 | Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy. | Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E | 26931511 PERFORM |
| 13 | Source localization of the seizure onset zone from ictal EEG/MEG data. | Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C | 27059157 PERFORM |
| 14 | Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method. | Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C | 29024165 PERFORM |
| 15 | Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG. | Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C | 28619655 PERFORM |
| Title: | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | ||||
| Authors: | Heers M, Afnan J, Braun C, Grova C, Altenmüller DM, Steinhoff BJ, Dümpelmann M, Demerath T, Urbach H, Ethofer S, Siegel M, Schulze-Bonhage A, Lerche H, Li Hegner Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41804684/ | ||||
| DOI: | 10.1002/epi.70191 | ||||
| Publication: | Epilepsia | ||||
| Keywords: | focal cortical dysplasia; focal epilepsy; magnetic source imaging; seizures; sleep; | ||||
| PMID: | 41804684 | Category: | Date Added: | 2026-03-10 | |
| Dept Affiliation: |
PERFORM
1 Epilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 2 Multimodal Functional Imaging Lab, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 3 Magnetoencephalography Center, University of Tübingen, Tübingen, Germany. 4 Department of Neural Dynamics and Magnetoencephalography, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 5 Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany. 6 Centre De Recherches Mathématiques, Montreal, Quebec, Canada. 7 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Center, Concordia University, Montreal, Quebec, Canada. 8 Epilepsy Center Kork, Kehl-Kork, Germany. 9 Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany. 10 BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany. 11 Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 12 Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany. 13 Center for Bionic Intelligence Tübingen Stuttgart, Tübingen, Germany. 14 German Center for Mental Health, Tübingen, Germany. 15 Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. |
||||
Description: |
Objective: Focal cortical dysplasia (FCD) causes drug-resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14-40 Hz) and gamma (40-80 Hz) frequency bands, and seizures. This study aimed to quantify sleep-associated changes in IEDs, FOs, and seizures in FCD patients using noninvasive magnetoencephalography (MEG). Methods: Nineteen patients with FCD were prospectively recruited and underwent simultaneous MEG/EEG recordings lasting 89 ± 19 min during daytime sleep. Sleep stages were classified from the EEG. Beamformer source signals were computed from the MEG signal to enhance sensitivity for visual detection of IEDs, FOs in the beta and gamma frequency bands, and seizures. Magnetic source imaging (MSI) was performed using the Maximum Entropy on the Mean (MEM) method, which is particularly sensitive to the spatial extent of sources, enabling accurate localization of epileptic activity. Results: N1 sleep was reached in 17 of 19 patients and N2 sleep in 14 of 19 patients. Compared to wakefulness, sleep recordings showed significantly higher rates of FOs and seizures (both p < .05), whereas IED rates showed nonsignificant trends. Ten patients demonstrated FOs or seizures, and 12 showed IEDs. MSI of IEDs demonstrated consistent accuracy across vigilance states, with median Euclidean distances of 12.74 mm (interquartile range [IQR] = 22.74) in wake and 8.34 mm (IQR = 27.58) in sleep, and no systematic amplitude or spatial extent changes. Wavelet-MEM enabled frequency-specific source imaging, with FOs and seizures localizing concordantly to FCD lesions in five of seven and seven of eight patients, respectively. Significance: Daytime sleep MEG recordings are clinically feasible and significantly enhance the detection of seizures (37% of patients) and FOs compared to wakefulness. Sleep protocols enable noninvasive capture of ictal patterns-the gold standard for epileptogenic zone localization-alongside increased FO rates. These findings support incorporating sleep into standard MEG protocols for presurgical epilepsy evaluation. |
