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| Title: | Natural history and determinants of dysglycemia in Canadian children with parental obesity from ages 8-10 to 15-17 years: The QUALITY cohort | ||||
| Authors: | Soren Harnois-Leblanc | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35023257/ | ||||
| DOI: | 10.1111/pedi.13315 | ||||
| Publication: | Pediatric diabetes | ||||
| Keywords: | children; insulin secretion; insulin sensitivity; lifestyle factors; type 2 diabetes; | ||||
| PMID: | 35023257 | Category: | Date Added: | 2022-01-13 | |
| Dept Affiliation: |
PERFORM
1 School of Public Health, Université de Montréal, Montréal, Québec, Canada. 2 Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada. 3 Research Centre of Centre Hospitalier Universitaire de Montréal, Montréal, Québec, Canada. 4 Ingram School of Nursing, McGill University, Montréal, Québec, Canada. 5 Department of Family Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada. 6 School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada. 7 PERFORM Centre and Department of Psychology, Faculty of Arts and Science, Concordia University, Montréal, Québec, Canada. 8 Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Québec, Canada. 9 Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada. 10 Department of Physical Education, Faculty of Education, Université Laval, Québec City, Québec, Canada. 11 Department of Pediatrics, Faculty of Medicine, Université de Montreal, Montréal, Québec, Canada. |
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Description: |
In children, the mechanisms implicated in deterioration of glucose homeostasis versus reversion to normal glucose tolerance (NGT) remain uncertain. We aimed to describe the natural history of dysglycemia from childhood to late adolescence and to identify its early determinants. We used baseline (8-10 years, n = 630), 1st follow-up (10-12 years, n = 564) and 2nd follow-up (15-17 years, n = 377) data from the QUALITY cohort of White Canadian children with parental obesity. Children underwent a 2-h... |
