PERFORM Publications

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Title		Authors	PubMed ID
1	Thermal sonogenetics for adoptive cell transfer therapy	Baez A; Hazel K; Guertin Z; Fong E; Manus MM; Kaloyannis A; Helfield B;	41748028 BIOLOGY
2	Characterizing forearm skeletal muscle composition and function in breast cancer-related lymphedema using B-mode ultrasonography	Whyte J; Towers A; Boily M; Rosenthall L; Rivaz H; Kilgour RD;	41674486 PERFORM
3	The effect of 14 days Actovegin administration with or without high intensity training on exercise capacity and skeletal muscle mitochondrial respiration	Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S;	41553522 HKAP
4	Associations of pregnancy complications with paternal cardiovascular risk: a retrospective cohort study	Mussa J; Wen L; Sharafi M; Gouin JP; Rahme E; Dasgupta K;	41407531 PSYCHOLOGY
5	Comparing the impact of in-person vs. virtual 10-week family-based childhood obesity management program on anthropometric, cardiometabolic, and mental health outcomes	Heidl AJ; Sun D; Faustini C; Gierc M; Bains A; Cohen TR;	41332896 MATHSTATS
6	Robust and Compact Electrostatic Comb Drive Arrays for High-Performance Monolithic Silicon Photonics	Fasihanifard M; Packirisamy M;	41156349 ENCS
7	Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions	Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM;	40585093 PSYCHOLOGY
8	Lasso Model-Based Optimization of CNC/CNF/rGO Nanocomposites	Ramezani G; Silva IO; Stiharu I; Ven TGMV; Nerguizian V;	40283268 ENCS
9	The effects of a 12-week combined motor control exercise and isolated lumbar extension intervention on lumbar multifidus muscle stiffness in individuals with chronic low back pain	Tornblom A; Naghdi N; Rye M; Montpetit C; Fortin M;	39258113 SOH
10	Identifying personalized barriers for hypertension self-management from TASKS framework	Yang J; Zeng Y; Yang L; Khan N; Singh S; Walker RL; Eastwood R; Quan H;	39143621 ENCS
11	The effect of EMS, IFC, and TENS on patient-reported outcome measures for chronic low back pain: a systematic review and meta-analysis	Wolfe D; Rosenstein B; Fortin M;	38979440 HKAP
12	Associations between valenced news and affect in daily life: Experimental and ecological momentary assessment approaches	Shaikh SJ; McGowan AL; Lydon-Staley DM;	38919709 PSYCHOLOGY
13	Morphological Changes of Deep Extensor Neck Muscles in Relation to the Maximum Level of Cord Compression and Canal Compromise in Patients With Degenerative Cervical Myelopathy	Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;	36289049 PERFORM
14	Cervical muscle morphometry and composition demonstrate prognostic value in degenerative cervical myelopathy outcomes	Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;	37745653 PERFORM
15	The Effect of Transcutaneous Electrotherapy on Lumbar Range of Motion and Paraspinal Muscle Characteristics in Chronic Low Back Pain Patients: A Systematic Review and Meta-Analysis	Wolfe D; Rosenstein B; Fortin M;	37510796 PERFORM
16	Acute evening high-intensity interval training may attenuate the detrimental effects of sleep restriction on long-term declarative memory	Emmanuel Frimpong	37084788 PERFORM
17	Family Members' Perceptions of Their Psychological Responses One Year Following Pediatric Intensive Care Unit (PICU) Hospitalization: Qualitative Findings From the Caring Intensively Study	Rennick JE; Knox AM; Treherne SC; Dryden-Palmer K; Stremler R; Chambers CT; McRae L; Ho M; Stack DM; Dougherty G; Fudge H; Campbell-Yeo M;	34557460 CONCORDIA
18	The effects of evening high-intensity exercise on sleep in healthy adults: A systematic review and meta-analysis	Frimpong E; Mograss M; Zvionow T; Dang-Vu TT;	34416428 PERFORM
19	Ultrasound Imaging Analysis of the Lumbar Multifidus Muscle Echo Intensity: Intra-Rater and Inter-Rater Reliability of a Novice and an Experienced Rater	Fortin M; Rosenstein B; Levesque J; Nandlall N;	34065340 PERFORM
20	Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.	Ali MY, Seong SH, Jung HA, Choi JS	31683604 CHEMBIOCHEM
21	Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study.	Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E	31507359 PERFORM
22	Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.	Voyer D, Lévesque D, Rompré PP	27267684 CSBN
23	Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.	Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN	28522313 CSBN
24	Intra-operative Video Characterization of Carotid Artery Pulsation Patterns in Case Series with Post-endarterectomy Hypertension and Hyperperfusion Syndrome.	Xiao Y, Rivaz H, Kasuya H, Yokosako S, Mindru C, Teitelbaum J, Sirhan D, Sinclair D, Angle M, Lo BWY	29322480 PERFORM

Title:	Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.
Authors:	Ali MY, Seong SH, Jung HA, Choi JS
Link:	https://www.ncbi.nlm.nih.gov/pubmed/31683604?dopt=Abstract
DOI:	10.3390/molecules24213937
Publication:	Molecules (Basel, Switzerland)
Keywords:	Angelica decursiva; angiotensin-I-converting enzyme; antihypertension; coumarins; molecular docking;
PMID:	31683604	Category:	Molecules	Date Added:	2019-11-07
Dept Affiliation:	CHEMBIOCHEM 1 Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. yousufbge@gmail.com. 2 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H4B 1R6, Canada. yousufbge@gmail.com. 3 Department of Biology, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC H4B 1R6, Canada. yousufbge@gmail.com. 4 Centre for Structural and Functional Genomic, Department of Biology, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC H4B 1R6, Canada. yousufbge@gmail.com. 5 Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. seongsuhui@naver.com. 6 Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Korea. jungha@jbnu.ac.kr. 7 Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. choijs@pknu.ac.kr.

Description:

Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.

Molecules. 2019 Oct 31;24(21):

Authors: Ali MY, Seong SH, Jung HA, Choi JS

Abstract

The bioactivity of ten traditional Korean Angelica species were screened by angiotensin-converting enzyme (ACE) assay in vitro. Among the crude extracts, the methanol extract of Angelica decursiva whole plants exhibited potent inhibitory effects against ACE. In addition, the ACE inhibitory activity of coumarins 1-5, 8-18 was evaluated, along with two phenolic acids (6, 7) obtained from A. decursiva. Among profound coumarins, 11-18 were determined to manifest marked inhibitory activity against ACE with IC50 values of 4.68-20.04 µM. Compounds 12, 13, and 15 displayed competitive inhibition against ACE. Molecular docking studies confirmed that coumarins inhibited ACE via many hydrogen bond and hydrophobic interactions with catalytic residues and zinc ion of C- and N-domain ACE that blocked the catalytic activity of ACE. The results derived from these computational and in vitro experiments give additional scientific support to the anecdotal use of A. decursiva in traditional medicine to treat cardiovascular diseases such as hypertension.

PMID: 31683604 [PubMed - in process]

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