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PubMed Publications| Keyword search (4,164 papers available) |  |
"Type 2 diabetes" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus | Plissonneau C; Santosa S; | 39553621 SOH |
| 2 | Natural history and determinants of dysglycemia in Canadian children with parental obesity from ages 8-10 to 15-17 years: The QUALITY cohort | Soren Harnois-Leblanc | 35023257 PERFORM |
| 3 | Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females | Kerri Z Delaney | 34985183 PERFORM |
| 4 | Metabolic networks of the human gut microbiota. | Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhein NJ, Aprikian S, Arshad R, Azuelos JD, Bernadotte D, Beswick N, Chazbey H, Church K, Ciubotaru E, D'Amato L, Del Corpo T, Deng J, Di Giulio BL, Diveeva D, Elahie E, Frank JGM, Furze E, Garner R, Gibbs V, Goldberg-Hall R, Goldman CJ, Goltsios FF, Gorjipour K, Grant T, Greco B, Guliyev N, Habrich A, Hyland H, Ibrahim N, Iozzo T, Jawaheer-Fenaoui A, Jaworski JJ, Jhajj MK, Jones J, Joyette R, Kaudeer S, Kelley S, Ki | 31799915 BIOLOGY |
| Title: | Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus | ||||
| Authors: | Plissonneau C, Santosa S | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/39553621/ | ||||
| DOI: | 10.1016/j.heliyon.2024.e39710 | ||||
| Publication: | Heliyon | ||||
| Keywords: | Adipose tissue; Body composition; Human; Inflammation; Obesity; Preadipocytes; Primary cells; Regional fat; Subcutaneous adipose tissue; Type 2 diabetes; Visceral adipose tissue; | ||||
| PMID: | 39553621 | Category: | Date Added: | 2024-11-18 | |
| Dept Affiliation: |
SOH
1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada. 2 Metabolism, Obesity, and Nutrition Lab, School of Health, Concordia University, Montreal, Quebec, Canada. 3 Centre de recherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada. |
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Description: |
The excessive accumulation of adipose tissue in obesity appears to result in adipose tissue dysfunction perpetuating the onset of obesity-related diseases, including type 2 diabetes (T2DM). In humans, adipose tissue is stored in several depots including subcutaneous and visceral. These depots contribute to the pathology of obesity differently owing to differences in the tissue microenvironment, a main one being preadipocyte function. In examining adipocyte and preadipocyte characteristics, many have used the 3T3-L1 murine cell lines. Though these cell lines provide valuable mechanistic data, the results remain to be translated to humans. Experiments using primary human preadipocytes has shown that obesity and T2DM impact preadipocyte phenotypes. The objective of this review is to describe the differences in regional characteristics of primary preadipocytes collected from humans with obesity and to discuss how these characteristics might be affected in type 2 diabetes mellitus. In doing so, we will show that the characteristics of regional primary preadipocytes in humans are differentially affected by obesity and the development of T2DM. |
