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PubMed Publications| Keyword search (4,164 papers available) |  |
"benzodiazepine" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk | Crane AL; Feyten LEA; Brusseau AJP; Dumaresq Synnott F; Ramnarine IW; Ferrari MCO; Brown GE; | 40905336 CONCORDIA |
| 2 | Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk | Crane AL; Feyten LEA; Brusseau AJP; Dumaresq Synnott F; Ramnarine IW; Ferrari MCO; Brown GE; | 40905351 CONCORDIA |
| 3 | Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults | Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H; | 40646404 PERFORM |
| 4 | Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia | Barbaux L; Perrault AA; Cross NE; Weiner OM; Es-Sounni M; Pomares FB; Tarelli L; McCarthy M; Maltezos A; Smith D; Gong K; O' Byrne J; Yue V; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Gilbert S; Tannenbaum C; Gouin JP; Dang-Vu TT; | 40570297 CSBN |
| Title: | Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia | ||||
| Authors: | Barbaux L, Perrault AA, Cross NE, Weiner OM, Es-Sounni M, Pomares FB, Tarelli L, McCarthy M, Maltezos A, Smith D, Gong K, O', Byrne J, Yue V, Desrosiers C, Clerc D, Andriamampionona F, Lussier D, Gilbert S, Tannenbaum C, Gouin JP, Dang-Vu TT | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40570297/ | ||||
| DOI: | 10.1093/sleep/zsaf168 | ||||
| Publication: | Sleep | ||||
| Keywords: | aging; benzodiazepine; brain oscillations; sleep; | ||||
| PMID: | 40570297 | Category: | Date Added: | 2025-06-26 | |
| Dept Affiliation: |
CSBN
1 Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology, School of Health & Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, QC, Canada. 2 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l'Ile-de-Montréal, Québec, Canada. 3 Sleep and Circadian Group, Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW, Australia. 4 School of Psychology, University of Sydney, NSW, Australia. 5 Statistics Canada Biobank, Statistics Canada, ON, Canada. 6 Department of Psychology, Université de Montréal, Montreal, QC, Canada. 7 Stress, Interpersonal Relationship and Health Lab, Department of Psychology & Centre for Clinical Research in Health, Concordia University, Quebec, Canada. |
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Description: |
Study objectives: Insomnia in older adults is associated with widespread benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) use, despite evidence that chronic use disrupts sleep regulation and cognition. Little is known about BZD/BZRA effects on NREM slow oscillations (SO), spindles and their coupling, which is crucial for memory, in older adults. Our objective was to investigate the effects of chronic BZD/BZRA use on sleep macro-architecture, EEG relative power, SO and spindle characteristics and coupling. Methods: After habituation polysomnography (PSG), second-night data were analyzed from 101 participants (66.05 ± 5.84 years, range: 55-80 years, 73% female) were categorized into three groups: good sleepers (GS, n = 28), individuals with insomnia (INS, n = 26) or individuals with insomnia who chronically use BZD/BZRA (MED, n = 47; diazepam equivalent: 6.1 ± 3.8 mg per use; >3 nights/week). We performed a comprehensive comparison of sleep architecture, EEG relative spectrum, and associated brain oscillatory activities, focusing on SO and spindles, and their temporal coupling. Results: MED showed disrupted sleep architecture with lower N3 and higher N1 duration and spectral activity, and altered sleep-related brain oscillations synchrony, compared to INS and GS. An exploratory interaction model suggested that chronic use of higher doses (mg per use) correlated with more pronounced disruptions in sleep micro-architecture and EEG spectrum. Conclusions: Our results suggest that chronic BZD and BZRA use is associated with poorer sleep quality. Such alteration of sleep regulation - at the macro and micro-architectural levels - may contribute to the reported association between BZD/BZRA use and cognitive impairment in older adults. |
