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PubMed Publications| Keyword search (4,163 papers available) |  |
"biomarkers" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterbe | 41020412 SOH |
| 2 | Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics | Abicumaran Uthamacumaran | 40848317 PSYCHOLOGY |
| 3 | The PREVENT-AD cohort: accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Valdez AF; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterberg H; S | 40778177 PSYCHOLOGY |
| 4 | Exosome Innovations in Ophthalmology and Sjögren s Syndrome | Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD; | 40360847 CONCORDIA |
| 5 | Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease | Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP; | 39878233 CONCORDIA |
| 6 | Isotopic and molecular analyses of n-alkanes in a temporal study of coastal sediment contributions to organic carbon degradation induced by algal bloom and terrestrial runoff | Mirzaei Y; Douglas PMJ; Gélinas Y; | 39700996 CHEMBIOCHEM |
| 7 | Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments | Vandersteen C; Plonka A; Manera V; Sawchuk K; Lafontaine C; Galery K; Rouaud O; Bengaied N; Launay C; Guérin O; Robert P; Allali G; Beauchet O; Gros A; | 37416323 CONCORDIA |
| 8 | Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection | Safiabadi Tali SH; LeBlanc JJ; Sadiq Z; Oyewunmi OD; Camargo C; Nikpour B; Armanfard N; Sagan SM; Jahanshahi-Anbuhi S; | 33980687 IMAGING |
| 9 | Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment | Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; | 31758692 CRDH |
| 10 | The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study. | Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ | 31309917 PSYCHOLOGY |
| 11 | Parental Nutrition Knowledge Rather Than Nutrition Label Use Is Associated With Adiposity in Children. | Kakinami L, Houle-Johnson S, McGrath JJ | 27373860 PERFORM |
| 12 | Sleep spindles may predict response to cognitive-behavioral therapy for chronic insomnia | Dang-Vu TT; Hatch B; Salimi A; Mograss M; Boucetta S; O' Byrne J; Brandewinder M; Berthomier C; Gouin JP; | 29157588 PERFORM |
| 13 | Gross Motor Skills Training Leads to Increased Brain-Derived Neurotrophic Factor Levels in Healthy Older Adults: A Pilot Study. | Grégoire CA, Berryman N, St-Onge F, Vu TTM, Bosquet L, Arbour N, Bherer L | 31031639 PERFORM |
| 14 | Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. | Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM | 28145075 PERFORM |
| Title: | Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease | ||||
| Authors: | Páez A, Gillman SO, Dogaheh SB, Carnes A, Dakterzada F, Barbé F, Dang-Vu TT, Ripoll GP | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/39878233/ | ||||
| DOI: | 10.1002/alz.14424 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | Alzheimer'; s disease; amyloid beta; biomarkers; cognition; cognitive decline; sleep; sleep spindles; slow oscillations; tau; | ||||
| PMID: | 39878233 | Category: | Date Added: | 2025-01-29 | |
| Dept Affiliation: |
CONCORDIA
1 Sleep, Cognition and Neuroimaging Laboratory, Concordia University, Montreal, Canada. 2 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montréal (Québec), Canada. 3 Nuffield Department for Primary Care Health Sciences, University of Oxford, Oxford, UK. 4 Unitat de Trastorns Cognitius, Cognition and Behavior Study Group, Hospital Universitari Santa Maria Universitat de Lleida, Lleida, Spain. 5 Translational Research in Respiratory Medicine (TRRM), Hospital Universitari Arnau de Vilanova-Santa Maria, Biomedical Research Institute of Lleida (IRBLleida), Lleida, Spain. 6 Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Fundació de Recerca Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. |
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Description: |
Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye movement sleep spindles and slow oscillations (SOs) at baseline and their associations with baseline amyloid beta (Aß) and tau and with cognition from baseline to 3-year follow-up. Results: Higher spindle and SO activity predicted significant changes in Aß and tau at baseline, lower Alzheimer's Disease Assessment Scale Cognitive Subscale (better cognitive performance) score, and higher Mini-Mental State Examination score from baseline to 36 months. Spindles and SOs mediated the effect of phosphorylated tau 181 (pTau181)/Aß42 on cognition, while pTau181/aß42 moderated the effect of spindles and SOs on cognition. Discussion: Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non-invasive biomarkers of neurodegeneration and cognition in AD patients. Highlights: Sleep spindles predict long-term cognitive performance in AD. Sleep spindle and SOs can be predictive, non-invasive biomarkers for AD. Sleep may be one of the most important modifiable risk factors for AD progression. Sleep microarchitecture is a novel therapeutic target for preserving brain heath. Sleep physiology can provide novel therapeutic targets to slow AD progression. |
