PERFORM Publications

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Title		Authors	PubMed ID
1	Dopamine inhibits excitatory synaptic responses in layer I of the rat parasubiculum	Carter F; Hobishi H; Chapman CA;	40818632 PSYCHOLOGY
2	Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach	Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL;	38460310 CHEMBIOCHEM
3	Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms	Pando-Naude V; Matthews TE; Højlund A; Jakobsen S; Østergaard K; Johnsen E; Garza-Villarreal EA; Witek MAG; Penhune V; Vuust P;	37724707 PSYCHOLOGY
4	Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward	Gonzalo R Quintana	36012194 PSYCHOLOGY
5	The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle	Pallikaras V; Shizgal P;	35431828 PSYCHOLOGY
6	The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands	Howland JG; Ito R; Lapish CC; Villaruel FR;	35131398 PSYCHOLOGY
7	The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch's law	Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P;	34864162 PSYCHOLOGY
8	Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons	Fernandes MF; Lau D; Sharma S; Fulton S;	33872705 CSBN
9	Neural substrates of appetitive and aversive prediction error.	Iordanova MD, Yau JO, McDannald MA, Corbit LH	33453307 CSBN
10	Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.	Mendoza JA, Lafferty CK, Yang AK, Britt JP	31693885 CSBN
11	High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.	Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG	27154458 CSBN
12	Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation.	Hernandez G, Cossette MP, Shizgal P, Rompré PP	27616984 PSYCHOLOGY
13	Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.	Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN	28522313 CSBN
14	Microbial Factories for the Production of Benzylisoquinoline Alkaloids.	Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ	26775900 BIOLOGY
15	Posterior dopamine D2/3 receptors and brain network functional connectivity.	Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C	28700819 PERFORM

Title:	Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.
Authors:	Mendoza JA, Lafferty CK, Yang AK, Britt JP
Link:	https://www.ncbi.nlm.nih.gov/pubmed/31693885?dopt=Abstract
DOI:	10.1016/j.celrep.2019.09.077
Publication:	Cell reports
Keywords:	calcium imaging; dopamine; expected value; motivation; optogenetics; overexpectation; reinforcement learning; reward prediction error; ventral tegmental area;
PMID:	31693885	Category:	Cell Rep	Date Added:	2019-11-07
Dept Affiliation:	CSBN 1 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 2 Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 3 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3

Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Abstract

Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear. In mice performing a trial-based operant task, we test if bidirectional manipulations of cue or operant-associated DA neuron activity drive learning as a result of under- or overexpectation of reward value. We target optogenetic manipulations to different components of forced trials, when only one lever is presented, and assess lever biases on choice trials in the absence of photomanipulation. Although lever biases are demonstrated to be flexible and sensitive to changes in expected value, augmentation of cue or operant-associated DA signaling does not significantly alter choice behavior, and blunting DA signaling during any component of the forced trials reduces choice trial responses on the associated lever. These data suggest cue-evoked DA helps maintain cue-value associations but does not encode expected value as to set the benchmark against which received reward is judged.

PMID: 31693885 [PubMed - in process]

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