Keyword search (4,164 papers available)

"drug discovery" Keyword-tagged Publications:

Title Authors PubMed ID
1 Ion channel classification through machine learning and protein language model embeddings Ghazikhani H; Butler G; 39572876
ENCS
2 Exploiting protein language models for the precise classification of ion channels and ion transporters Ghazikhani H; Butler G; 38656743
CSFG
3 Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease Nayak SS; Naidu A; Sudhakaran SL; Vino S; Selvaraj G; 37109050
CHEMBIOCHEM
4 Drug discovery and chemical probing in Drosophila. Millet-Boureima C, Selber-Hnatiw S, Gamberi C 32551911
BIOLOGY

 

Title:Drug discovery and chemical probing in Drosophila.
Authors:Millet-Boureima CSelber-Hnatiw SGamberi C
Link:https://www.ncbi.nlm.nih.gov/pubmed/32551911?dopt=Abstract
DOI:10.1139/gen-2020-0037
Publication:Genome
Keywords:Drosophilacriblage de composésdrug discoverydrug screenscouverte de médicamentsmaladies orphelinesmodèles animauxorphan diseasepathway probingpolycystic kidney diseasepolykystose rénalesondage des sentierswhole-animal models
PMID:32551911 Category:Genome Date Added:2020-06-20
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

Drug discovery and chemical probing in Drosophila.

Genome. 2020 Jun 18;:

Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Abstract

Flies are increasingly utilized in drug discovery and chemical probing in vivo, which are novel technologies complementary to genetic probing in fundamental biological studies. Excellent genetic conservation, small size, short generation time and over one hundred years of genetics make Drosophila an attractive model for rapid assay readout and use of analytical amounts of compound, enabling the experimental iterations needed in early drug development at a fraction of time and costs. Here, we describe an effective drug-testing pipeline using adult flies that can be easily implemented to study several disease models and different genotypes to discover novel molecular insight, probes, quality lead compounds, and develop novel prototype drugs.

PMID: 32551911 [PubMed - as supplied by publisher]





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