Keyword search (4,164 papers available)

"genomics" Keyword-tagged Publications:

Title Authors PubMed ID
1 Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G; 41794383
HKAP
2 Season and city shape urban bioaerosol composition beyond vegetation and socioeconomic gradients Poirier S; Rondeau-Leclaire J; Faticov M; Roy A; Lajeunesse G; Lucier JF; Tardif S; Kembel SW; Ziter C; Laprise C; Paquette A; Girard C; Laforest-Lapointe I; 41785576
BIOLOGY
3 Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in em Caenorhabditis elegans, /em challenges a proposed role in heme trafficking Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ; 41504601
BIOLOGY
4 Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood Won Kang JR; Kim YJ; Skead K; Soave D; Evans J; Bruat V; Harwood MP; Morris Q; Matovu E; Mulindwa J; Noyes H; McLeod A; Hazelhurst S; Lombard Z; Ramsay M; Fave MJ; Awadalla P; 41282824
BIOLOGY
5 Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P; 39920830
BIOLOGY
6 Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ; 39730611
BIOLOGY
7 Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J; Kuasne H; Li R; Bourgey M; Fortier AM; Davison PG; Omeroglu A; Guiot MC; Morris Q; Kleinman CL; Huang S; Gingras AC; Ragoussis J; Bourque G; Van Loo P; Park M; 38517886
BIOLOGY
8 Editorial: Computational systems immunovirology Zarei Ghobadi M; Teymoori-Rad M; Selvaraj G; Wei DQ; 37475870
CHEMBIOCHEM
9 Rethinking microbial infallibility in the metagenomics era O' Malley MA; Walsh DA; 34160589
BIOLOGY
10 ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance Lismer A; Lambrot R; Lafleur C; Dumeaux V; Kimmins S; 34159325
PERFORM
11 A Novel Freshwater to Marine Evolutionary Transition Revealed within Methylophilaceae Bacteria from the Arctic Ocean Ramachandran A; McLatchie S; Walsh DA; 34154421
BIOLOGY
12 Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I; 34064722
BIOLOGY
13 Core Competencies in Cancer Genomics for Healthcare Professionals: Results From a Systematic Literature Review and a Delphi Process. Hoxhaj I, Tognetto A, Acampora A, Stojanovic J, Boccia S 33442861
HKAP
14 Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes. Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Pierella Karlusich JJ, Pelletier E, Morlon H, Bowler C, Blanc G 33419955
BIOLOGY
15 Genome Sequence Resource of Bacillus velezensis EB14, a native endophytic bacterial strain with biocontrol potential against the poplar stem canker causative pathogen, Sphaerulina musiva. Naik S, Tsang A, Ramanan US, Dayanandan S 33263425
BIOLOGY
16 Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors. Manjunath M; Yan J; Youn Y; Drucker KL; Kollmeyer TM; McKinney AM; Zazubovich V; Zhang Y; Costello JF; Eckel-Passow J; Selvin PR; Jenkins RB; Song JS; 33130899
PHYSICS
17 Sediment Metagenomes as Time Capsules of Lake Microbiomes. Garner RE; Gregory-Eaves I; Walsh DA; 33148818
BIOLOGY
18 Size reductions and genomic changes within two generations in wild walleye populations: associated with harvest? Bowles E, Marin K, Mogensen S, MacLeod P, Fraser DJ 32684951
CONCORDIA
19 Plasma levels of one-carbon metabolism nutrients in women with anorexia nervosa Burdo J; Booij L; Kahan E; Thaler L; Israƫl M; Agellon LB; Nitschmann E; Wykes L; Steiger H; 32427359
PSYCHOLOGY
20 Diversity, evolution, and classification of virophages uncovered through global metagenomics. Paez-Espino D, Zhou J, Roux S, Nayfach S, Pavlopoulos GA, Schulz F, McMahon KD, Walsh D, Woyke T, Ivanova NN, Eloe-Fadrosh EA, Tringe SG, Kyrpides NC 31823797
BIOLOGY
21 Enzymes of early-diverging, zoosporic fungi. Lange L, Barrett K, Pilgaard B, Gleason F, Tsang A 31309267
CSFG
22 Chaco Canyon Dig Unearths Ethical Concerns. Claw KG, Lippert D, Bardill J, Cordova A, Fox K, Yracheta JM, Bader AC, Bolnick DA, Malhi RS, TallBear K, Garrison NA 29745246
CONCORDIA
23 Genetics of mating in members of the Chaetomiaceae as revealed by experimental and genomic characterization of reproduction in Myceliophthora heterothallica. Hutchinson MI, Powell AJ, Tsang A, O'Toole N, Berka RM, Barry K, Grigoriev IV, Natvig DO 26608618
CSFG
24 An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger. Niu J, Alazi E, Reid ID, Arentshorst M, Punt PJ, Visser J, Tsang A, Ram AF 28049705
CSFG
25 Thermostable xylanases from thermophilic fungi and bacteria: Current perspective. Chadha BS, Kaur B, Basotra N, Tsang A, Pandey A 30679061
CSFG

 

Title:Diversity, evolution, and classification of virophages uncovered through global metagenomics.
Authors:Paez-Espino DZhou JRoux SNayfach SPavlopoulos GASchulz FMcMahon KDWalsh DWoyke TIvanova NNEloe-Fadrosh EATringe SGKyrpides NC
Link:https://www.ncbi.nlm.nih.gov/pubmed/31823797?dopt=Abstract
DOI:10.1186/s40168-019-0768-5
Publication:Microbiome
Keywords:Global distributionMajor capsid protein (MCP)MetagenomicsVirophageVirophage classificationVirophage-NCLDV interactions
PMID:31823797 Category:Microbiome Date Added:2019-12-12
Dept Affiliation: BIOLOGY
1 Department of Energy, Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, 94598, USA. adpaezespino@lbl.gov.
2 Department of Energy, Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, 94598, USA.
3 BSRC "Alexander Fleming", 34 Fleming Street, Vari, 16672, Athens, Greece.
4 Departments of Civil and Environmental Engineering and Bacteriology, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI, 53726, USA.
5 Department of Biology, Concordia University, 7141 Sherbrooke St. West, Montreal, QC, H4B 1R6, Canada.
6 Department of Energy, Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, 94598, USA. sgtringe@lbl.gov.
7 Department of Energy, Joint Genome Institute, 2800 Mitchell Dr., Walnut Creek, 94598, USA. nckyrpides@lbl.gov.

Description:

Diversity, evolution, and classification of virophages uncovered through global metagenomics.

Microbiome. 2019 Dec 10;7(1):157

Authors: Paez-Espino D, Zhou J, Roux S, Nayfach S, Pavlopoulos GA, Schulz F, McMahon KD, Walsh D, Woyke T, Ivanova NN, Eloe-Fadrosh EA, Tringe SG, Kyrpides NC

Abstract

BACKGROUND: Virophages are small viruses with double-stranded DNA genomes that replicate along with giant viruses and co-infect eukaryotic cells. Due to the paucity of virophage reference genomes, a collective understanding of the global virophage diversity, distribution, and evolution is lacking.

RESULTS: Here we screened a public collection of over 14,000 metagenomes using the virophage-specific major capsid protein (MCP) as "bait." We identified 44,221 assembled virophage sequences, of which 328 represent high-quality (complete or near-complete) genomes from diverse habitats including the human gut, plant rhizosphere, and terrestrial subsurface. Comparative genomic analysis confirmed the presence of four core genes in a conserved block. We used these genes to establish a revised virophage classification including 27 clades with consistent genome length, gene content, and habitat distribution. Moreover, for eight high-quality virophage genomes, we computationally predicted putative eukaryotic virus hosts.

CONCLUSION: Overall, our approach has increased the number of known virophage genomes by 10-fold and revealed patterns of genome evolution and global virophage distribution. We anticipate that the expanded diversity presented here will provide the backbone for further virophage studies.

PMID: 31823797 [PubMed - in process]





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