Keyword search (4,164 papers available)

"heroin" Keyword-tagged Publications:

Title Authors PubMed ID
1 The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats Borges C; Darecka A; Mainville-Berthiaume A; Ah-Yen E; Darvishmolla M; Courtemanche R; Shalev U; 41506524
HKAP
2 Learning from opioid withdrawal: Effects on striatal dopamine (Commentary on Ahn et al., 2023) Leyton M; Nikolic M; 38129315
CSBN
3 Modulation of cue value and the augmentation of heroin seeking in chronically food-restricted male rats under withdrawal Firas Sedki 37714221
CSBN
4 Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S; 35951079
CSBN
5 A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction. D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U 31811350
PSYCHOLOGY

 

Title:A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.
Authors:D'Cunha TM,  Chisholm A,  Hryhorczuk C,  Fulton S,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/31811350
DOI:10.1007/s00213-019-05415-9
Publication:Psychopharmacology
Keywords:Food restriction;  Ghrelin;  Heroin;  Leptin;  Self-administration;  Ventral tegmental area; 
PMID:31811350 Category:Psychopharmacology (Berl) Date Added:2019-12-08
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
2 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.
3 Centre de Recherche du CHUM, Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada.
4 Department of Psychology, Concordia University, Montreal, Quebec, Canada. uri.shalev@concordia.ca.
5 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada. uri.shalev@concordia.ca.

Description:

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.

OBJECTIVES: We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

METHODS: Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 µg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 µg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 µg/side) directly into the VTA prior to the heroin-seeking test.

RESULTS: Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.

CONCLUSIONS: Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.

PMID: 31811350 [PubMed - indexed for MEDLINE]




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