Keyword search (4,163 papers available)

"intellectual disability" Keyword-tagged Publications:

Title Authors PubMed ID
1 Searching for balance: The effects of dance training on the postural stability of individuals with intellectual disability DiPasquale S; Roberts M; 39818618
HKAP
2 Longitudinal Associations Between Relationship Quality and Depression Among Youth with Intellectual Disabilities: A Latent Change Perspective Dubé C; Morin AJS; Olivier E; Tóth-Király I; Tracey D; Craven RG; Maïano C; 36436145
PSYCHOLOGY
3 Social Interaction Profiles Among Youth with Intellectual Disabilities: Associations with Indicators of Psychosocial Adjustment Dubé C; Morin AJS; Tóth-Király I; Olivier E; Tracey D; McCune VS; Craven RG; Maïano C; 36342629
PSYCHOLOGY
4 Validation of an Adapted Version of the Glasgow Anxiety Scale for People with Intellectual Disabilities (GAS-ID) Maïano C; Morin AJS; Gagnon C; Olivier E; Tracey D; Craven RG; Bouchard S; 35138559
PSYCHOLOGY
5 Validation of a Revised Version of the Center for Epidemiologic Depression Scale for Youth with Intellectual Disabilities (CESD-ID-R) Olivier E; Lacombe C; Morin AJS; Houle SA; Gagnon C; Tracey D; Craven RG; Maïano C; 34716523
PSYCHOLOGY
6 A psychometric validation of the motives for physical activity measure for youth with intellectual disabilities (MPAM-ID) Maïano C; Morin AJS; Tracey D; Gagnon C; Smodis McCune V; Craven RG; 34528859
PSYCHOLOGY
7 Development and Validation of a Multi-informant Measure of Social Behaviors for Youth with Intellectual Disabilities Olivier E; Morin AJS; Tracey D; Verma N; Dubé C; Gagnon C; Craven RG; Maïano C; 34255229
PSYCHOLOGY
8 Toward a Comprehensive Assessment of Relationships with Teachers and Parents for Youth with Intellectual Disabilities Dubé C; Olivier E; Morin AJS; Tracey D; Craven RG; Maïano C; 34185237
PSYCHOLOGY
9 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM
10 Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Collins F, Willis MJH, Coban Akdemir ZH, Liu P, Punetha J, Hunter JV, Jhangiani SN, Fatih JM, Rosenfeld JA, Posey JE, Gibbs RA, Karaca E, Massey S, Ranasinghe TG, Sleiman P, Troedson C, Lupski JR, Sacher M, Segev N, Hakonarson H, Christodoulou J 31794024
BIOLOGY

 

Title:Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Authors:Tamming RJDumeaux VJiang YShafiq SLanglois LEllegood JQiu LRLerch JPBérubé NG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32610139?dopt=Abstract
DOI:10.1016/j.celrep.2020.107838
Publication:Cell reports
Keywords:ATRXH3K27me3chromatinhippocampusintellectual disabilitylong-term spatial memorymiR-137presynaptic vesiclessex differencessynapse
PMID:32610139 Category:Cell Rep Date Added:2020-07-02
Dept Affiliation: PERFORM
1 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada.
2 Department of Paediatrics, Western University, London, ON, Canada; PERFORM Centre, Concordia University, Montreal, QC, Canada.
3 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada.
4 Children's Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
5 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
6 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
7 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
8 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
9 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: nberube@uwo.ca.

Description:

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Cell Rep. 2020 Jun 30;31(13):107838

Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Abstract

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deletion of neuronal Atrx in mice leads to distinct hippocampal structural defects, fewer presynaptic vesicles, and an enlarged postsynaptic area at CA1 apical dendrite-axon junctions. We identify male-specific impairments in long-term contextual memory and in synaptic gene expression, linked to altered miR-137 levels. We show that ATRX directly binds to the miR-137 locus and that the enrichment of the suppressive histone mark H3K27me3 is significantly reduced upon the loss of ATRX. We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction.

PMID: 32610139 [PubMed - as supplied by publisher]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University