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PubMed Publications| Keyword search (4,163 papers available) |  |
"lung" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Lung Nodule Malignancy Classification Integrating Deep and Radiomic Features in a Three-Way Attention-Based Fusion Module | Khademi S; Heidarian S; Afshar P; Mohammadi A; Sidiqi A; Nguyen ET; Ganeshan B; Oikonomou A; | 41150036 ENCS |
| 2 | Virtual reality-based preoperative planning for optimized trocar placement in thoracic surgery: A preliminary study | Harirpoush A; Rakovich G; Kersten-Oertel M; Xiao Y; | 39720764 ENCS |
| 3 | Translating the Interplay of Cognition and Physical Performance in COPD and Interstitial Lung Disease: Meeting Report and Literature Review | Rozenberg D; Reid WD; Camp P; Campos JL; Dechman G; Davenport PW; Egan H; Fisher JH; Guenette JA; Gold D; Goldstein RS; Goodridge D; Janaudis-Ferreira T; Kaplan AG; Langer D; Marciniuk DD; Moore B; Orchanian-Cheff A; Otoo-Appiah J; Pepin V; Rassam P; Rotenberg S; Ryerson C; Spruit MA; Stanbrook MB; Stickland MK; Tom J; Wentlandt K; | 38901488 HKAP |
| 4 | Curcumin inhibition of bleomycin-induced changes in lung collagen synthesis, deposition and assembly | Durairaj P; Venkatesan S; Narayanan V; Babu M; | 34643929 BIOLOGY |
| 5 | Defective GaAs nanoribbon-based biosensor for lung cancer biomarkers: a DFT study | Tarun T; Singh P; Kaur H; Walia GK; Randhawa DKK; Choudhary BC; | 34459994 ENCS |
| 6 | Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis | Huang S; Wei YK; Kaliamurthi S; Cao Y; Nangraj AS; Sui X; Chu D; Wang H; Wei DQ; Peslherbe GH; Selvaraj G; Shi J; | 33050659 CHEMBIOCHEM |
| 7 | Protective effects of curcumin on bleomycin-induced changes in lung glycoproteins. | Durairaj P, Venkatesan S, Narayanan V, Babu M | 32350681 BIOLOGY |
| 8 | Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures | Simó M; Gurtubay-Antolin A; Vaquero L; Bruna J; Rodríguez-Fornells A; | 29387526 MLNP |
| Title: | Curcumin inhibition of bleomycin-induced changes in lung collagen synthesis, deposition and assembly | ||||
| Authors: | Durairaj P, Venkatesan S, Narayanan V, Babu M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34643929/ | ||||
| DOI: | 10.1007/s11033-021-06790-3 | ||||
| Publication: | Molecular biology reports | ||||
| Keywords: | Bleomycin; Collagen; Curcumin; Extracellular matrix; Lung fibrosis; | ||||
| PMID: | 34643929 | Category: | Date Added: | 2021-10-13 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Biotechnology, Central Leather Research Institute, Chennai, India. 2 Biology Department, Concordia University, Montreal, Canada. 3 Department of Biochemistry, Central Leather Research Institute, Chennai, India. vnar12@yahoo.com. 4 , Montreal, Canada. vnar12@yahoo.com. 5 Cavinkare Pharmaceuticals, Chennai, India. |
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Description: |
Background: Idiopathic pulmonary fibrosis is characterized by progressive lung tissue remodeling and disproportionate deposition of collagenous proteins with limited therapeutic interventions. The purpose of this study was to determine whether curcumin inhibits bleomycin (BLM)-induced increases in synthesis, degradation and cross-linking of lung collagen in rats. Methods and results: Following a single intratracheal instillation of BLM to rats (0.75 U/100 g, sacrificed 3, 5, 7, 14 and 28 days post-BLM), lung collagen synthesis (determined by incorporation of 3H-proline) and deposition (determined by lung hydroxyproline content) progressively increased at days 7, 14 and 28 post-BLM injection. Lung lavage fluid hydroxyproline and collagenase levels (a measure of collagen turnover) were increased in BLM rats compared with control groups. In addition, BLM instillation resulted in increased concentrations of collagenase and collagenolytic cathepsin in the lungs. Furthermore, increased cross-linking (as determined by aldehyde content of acid soluble collagen), and decreased susceptibility of fibrotic lung insoluble collagen to denaturing agents occurred in BLM-injured lungs. Significant increases in alveolar macrophage (AM) release of transforming growth factor-ß1 (TGF-ß1) were noted at various time points (days 3, 5, 7, 14 and 28 post-BLM) during the development and progression of lung fibrosis in rats. Curcumin treatment to BLM rats (300 mg/kg 10 days before and daily thereafter throughout the experimental time period) was associated with marked reductions in lung collagen synthesis and deposition, BALF and lung collagenase activity, BALF hydroxyproline content and lung collagenolytic levels. Additionally, reduced levels of collagen cross-linking and enhanced susceptibility of insoluble lung collagen to denaturing agents were observed in curcumin-treated BLM rats. Finally, curcumin inhibited BLM-induced increases in AM production of TGF-ß1. Conclusions: Our data demonstrate for the first time that curcumin prevents fibrotic deposits by modulating collagen turnover, assembly and deposition in BLM-instilled rat lungs, and that curcumin treatment protects against BLM activation of macrophages by suppressing the release of TGF-ß1. |
