PERFORM Publications

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Title		Authors	PubMed ID
1	Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors	Bdair H; Singleton TA; Ross K; Jolly D; Kang MS; Aliaga A; Tuznik M; Kaur T; Yous S; Soucy JP; Massarweh G; Scott PJH; Koeppe R; Spadoni G; Bedini A; Rudko DA; Gobbi G; Benkelfat C; Rosa-Neto P; Brooks AF; Kostikov A;	35420022 PERFORM
2	Empowering Melatonin Therapeutics with Drosophila Models	Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C;	34698120 BIOLOGY
3	Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.	Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;	33238462 BIOLOGY

Title:	Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.
Authors:	Millet-Boureima C, Rozencwaig R, Polyak F, Gamberi C
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33238462
DOI:	10.3390/molecules25225477
Publication:	Molecules (Basel, Switzerland)
Keywords:	Drosophila; longevity; melatonin; oxidative stress; polycystic kidney disease; renal cysts;
PMID:	33238462	Category:	Molecules	Date Added:	2020-11-27
Dept Affiliation:	BIOLOGY 1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 BH Bioscience, Montreal, QC H3W 2L2, Canada.

Description:

Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Molecules. 2020 Nov 23; 25(22):

Authors: Millet-Boureima C, Rozencwaig R, Polyak F, Gamberi C

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.

PMID: 33238462 [PubMed - in process]

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