PERFORM Publications

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Title		Authors	PubMed ID
1	Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in em Caenorhabditis elegans, /em challenges a proposed role in heme trafficking	Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;	41504601 BIOLOGY
2	Global survey of secondary metabolism in em Aspergillus niger /em via activation of specific transcription factors	Semper C; Pham TTM; Ram S; Palys S; Evdokias G; Ouedraogo JP; Moisan MC; Geoffrion N; Reid I; Di Falco M; Bailey Z; Tsang A; Benoit-Gelber I; Savchenko A;	40852424 GENOMICS
3	Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans	Costa DN; Santosa S; Jensen MD;	39869194 SOH
4	Lactate's behavioral switch in the brain: An in-silico model	Soltanzadeh M; Blanchard S; Soucy JP; Benali H;	37865309 PERFORM
5	The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans	Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;	37791798 BIOLOGY
6	The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum	Li J; Chroumpi T; Garrigues S; Kun RS; Meng J; Salazar-Cerezo S; Aguilar-Pontes MV; Zhang Y; Tejomurthula S; Lipzen A; Ng V; Clendinen CS; Tolic N; Grigoriev IV; Tsang A; Mäkelä MR; Snel B; Peng M; de Vries RP;	36547648 BIOLOGY
7	Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction	Anne-Sophie Pepin	35183795 PERFORM
8	Bioinspired facilitation of intrinsically conductive polymers: Mediating intra/extracellular electron transfer and microbial metabolism in denitrification	Guo T; Lu C; Chen Z; Song Y; Li H; Han Y; Hou Y; Zhong Y; Guo J;	35124084 ENCS
9	Altered immunometabolism in adipose tissue: a major contributor to the ageing process?	Delaney KZ; Gillespie ZE; Murphy J; Wang C;	34159597 PERFORM
10	Ghrelin receptor signalling is not required for glucocorticoid-induced obesity in female mice	Silver Z; Abbott-Tate S; Hyland L; Sherratt F; Woodside B; Abizaid A;	34060474 CSBN
11	Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors	Mohammad K; Titorenko VI;	33868583 BIOLOGY
12	Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.	Tam BT, Murphy J, Khor N, Morais JA, Santosa S	32808657 PERFORM
13	Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.	Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI	32630624 BIOLOGY
14	Plasma levels of one-carbon metabolism nutrients in women with anorexia nervosa	Burdo J; Booij L; Kahan E; Thaler L; Israël M; Agellon LB; Nitschmann E; Wykes L; Steiger H;	32427359 PSYCHOLOGY
15	Evolutionary adaptation of Aspergillus niger for increased ferulic acid tolerance.	Lubbers RJM, Liwanag AJ, Peng M, Dilokpimol A, Benoit-Gelber I, de Vries RP	31674709 CSFG
16	Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.	Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI	31645900 BIOLOGY
17	Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry	Slobodchikova I; Sivakumar R; Rahman MS; Vuckovic D;	31344861 CBAMS
18	Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.	Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI	25839782 MASSSPEC
19	Some Metabolites Act as Second Messengers in Yeast Chronological Aging.	Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI	29543708 BIOLOGY
20	Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.	Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI	29662634 BIOLOGY
21	Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.	Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI	30405886 BIOLOGY
22	Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids.	Pyne ME, Narcross L, Fossati E, Bourgeois L, Burton E, Gold ND, Martin VJ	27417930 CSFG
23	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS	28476332 PERFORM
24	Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.	Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS	29339225 PERFORM
25	The Sexual Dimorphism of Lipid Kinetics in Humans.	Santosa S, Jensen MD	26191040 PERFORM
26	Impaired sensorimotor processing during complex gait precedes behavioral changes in middle-aged adults.	Mitchell T, Starrs F, Soucy JP, Thiel A, Paquette C	30247510 PERFORM

Title:	Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.
Authors:	Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI
Link:	https://www.ncbi.nlm.nih.gov/pubmed/31645900?dopt=Abstract
DOI:	10.18632/oncotarget.27209
Publication:	Oncotarget
Keywords:	cellular aging; geroprotectors; lipid metabolism; mitochondria; necrotic cell death;
PMID:	31645900	Category:	Oncotarget	Date Added:	2019-10-25
Dept Affiliation:	BIOLOGY 1 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. 2 Idunn Technologies Inc., Rosemere, Quebec J7A 4A5, Canada.

Description:

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.

Oncotarget. 2019 Oct 08;10(56):5780-5816

Authors: Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI

Abstract

We have recently found that PE21, an extract from the white willow Salix alba, slows chronological aging and prolongs longevity of the yeast Saccharomyces cerevisiae more efficiently than any of the previously known pharmacological interventions. Here, we investigated mechanisms through which PE21 delays yeast chronological aging and extends yeast longevity. We show that PE21 causes a remodeling of lipid metabolism in chronologically aging yeast, thereby instigating changes in the concentrations of several lipid classes. We demonstrate that such changes in the cellular lipidome initiate three mechanisms of aging delay and longevity extension. The first mechanism through which PE21 slows aging and prolongs longevity consists in its ability to decrease the intracellular concentration of free fatty acids. This postpones an age-related onset of liponecrotic cell death promoted by excessive concentrations of free fatty acids. The second mechanism of aging delay and longevity extension by PE21 consists in its ability to decrease the concentrations of triacylglycerols and to increase the concentrations of glycerophospholipids within the endoplasmic reticulum membrane. This activates the unfolded protein response system in the endoplasmic reticulum, which then decelerates an age-related decline in protein and lipid homeostasis and slows down an aging-associated deterioration of cell resistance to stress. The third mechanisms underlying aging delay and longevity extension by PE21 consists in its ability to change lipid concentrations in the mitochondrial membranes. This alters certain catabolic and anabolic processes in mitochondria, thus amending the pattern of aging-associated changes in several key aspects of mitochondrial functionality.

PMID: 31645900 [PubMed]

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