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PubMed Publications| Keyword search (4,163 papers available) |  |
"neurodegenerative diseases" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Exploring neurologists perspectives: barriers and facilitators in implementing cognitive care planning | Ge S; Xiao X; Huang B; Britt KC; | 41163714 CONCORDIA |
| 2 | In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis | Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS; | 40516590 CHEMBIOCHEM |
| 3 | Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders | Eskandari K; Bélanger SM; Lachance V; Kourrich S; | 40430519 CSBN |
| 4 | Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities | Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM; | 39364217 PSYCHOLOGY |
| 5 | Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study. | Pieruccini-Faria F, Black SE, Masellis M, Smith EE, Almeida QJ, Li KZH, Bherer L, Camicioli R, Montero-Odasso M | 33590967 PSYCHOLOGY |
| 6 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| Title: | In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis | ||||
| Authors: | Silva MCJD, Pinto AMV, Balthar MA, Correa ABA, Bhattacharyya D, Simas ABC, Kuca K, Forgione P, França TCC, Cavalcante SFA, Kitagawa DAS | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40516590/ | ||||
| DOI: | 10.1016/j.cbi.2025.111605 | ||||
| Publication: | Chemico-biological interactions | ||||
| Keywords: | Acetylcholinesterase; Alzheimer; inhibition; isatin; neurodegenerative diseases; organophosphorus; reactivators; | ||||
| PMID: | 40516590 | Category: | Date Added: | 2025-06-15 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil; Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil. Electronic address: cristina.munique@eb.mil.br. 2 Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil. Electronic address: amanda.moraes@ime.eb.br. 3 Medical Course, Souza Marques College (FSM), Rio de Janeiro, RJ, Brazil. Electronic address: marianabalthar@gmail.com. 4 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: anabeatriz.correa@eb.mil.br. 5 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada. Electronic address: dipanjan.bhattacharyya@concordia.ca. 6 Laboratory Roderick A. Barnes, Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, 21941-902, Rio de Janeiro, RJ, Brazil. Electronic address: abcsimas@ippn.ufrj.br. 7 Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic. Electronic address: kamil.kuca@uhk.cz. 8 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada. Electronic address: pat.forgione@concordia.ca. 9 Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic. Electronic address: tanos@ime.eb.br. 10 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: samir.cavalcante@eb.mil.br. 11 Agency for Management and Technological Innovation (AGITEC), Brazilian Army Department of Science and Technology, Avenida das Américas 28705, 23020-470, Rio de Janeiro, RJ, Brazil. Electronic address: kitagawa.daniel@eb.mil.br. |
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Description: |
Given the recent deployment of nerve agents as a method of warfare and in targeted assassinations, the development of robust, broad-spectrum medical countermeasures is essential. Our research group has synthesized isatin-pyridine oxime hybrids that have previously demonstrated the ability to rescue Electrophorus eel acetylcholinesterase (EeAChE) inhibited by nerve agent surrogates. In this work, we investigate the in vitro AChE inhibitory properties of these hybrids, estimating their IC50. Compounds 14 and 15 evidenced inhibitiory ability (226.4 and 24.7 µM of IC50, respectively), and this last was similar to compound reference pyridostigmine bromide, the only reported drug used as prophylactic measure for nerve agent exposure. Results suggest promisor dual-functional compounds for nerve agent prophylaxis and the reactivation of enzyme catalytic activity. |
