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PubMed Publications| Keyword search (4,163 papers available) |  |
"preclinical" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterbe | 41020412 SOH |
| 2 | The PREVENT-AD cohort: accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Valdez AF; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterberg H; S | 40778177 PSYCHOLOGY |
| 3 | Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 | McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilbert R; Gadoury C; Iqbal U; Fatehi D; Jezierski A; Huang J; Pon RA; Sigrist M; Holt RA; Nelson BH; Atkins H; Kekre N; Yung E; Webb J; Nielsen JS; Weeratna RD; | 38596311 BIOLOGY |
| 4 | Brain PET Imaging in Small Animals: Tracer Formulation, Data Acquisition, Image Reconstruction, and Data Analysis | Bdair H; Kang MS; Ottoy J; Aliaga A; Kunach P; Singleton TA; Blinder S; Soucy JP; Leyton M; Rosa-Neto P; Kostikov A; | 38006502 PERFORM |
| 5 | The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol. | Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG | 32087523 PSYCHOLOGY |
| 6 | Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone. | Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG | 31447629 CSBN |
| 7 | Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. | Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative | 29396637 PERFORM |
| Title: | Brain PET Imaging in Small Animals: Tracer Formulation, Data Acquisition, Image Reconstruction, and Data Analysis | ||||
| Authors: | Bdair H, Kang MS, Ottoy J, Aliaga A, Kunach P, Singleton TA, Blinder S, Soucy JP, Leyton M, Rosa-Neto P, Kostikov A | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38006502/ | ||||
| DOI: | 10.1007/978-1-0716-3499-8_16 | ||||
| Publication: | Methods in molecular biology (Clifton, N.J.) | ||||
| Keywords: | PET image acquisition; PET image analysis; PET image reconstruction; PET tracers; Positron emission tomography; Preclinical imaging; | ||||
| PMID: | 38006502 | Category: | Date Added: | 2023-11-26 | |
| Dept Affiliation: |
PERFORM
1 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. 2 Department of Psychiatry, McGill University, Montreal, QC, Canada. 3 McConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital (The Neuro), McGill University, Montreal, QC, Canada. 4 Translational Neuroimaging Laboratory, Research Centre for Studies in Aging, Douglas Research Institute, McGill University, Montreal, QC, Canada. 5 LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. 6 PERFORM Centre, Concordia University, Montreal, QC, Canada. 7 Department of Psychology, McGill University, Montreal, QC, Canada. 8 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. 9 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. alexey.kostikov@mcgill.ca. 10 Translational Neuroimaging Laboratory, Research Centre for Studies in Aging, Douglas Research Institute, McGill University, Montreal, QC, Canada. alexey.kostikov@mcgill.ca. 11 McConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital (The Neuro), McGill University, Montreal, QC, Canada. alexey.kostikov@mcgill.ca. 12 Department of Chemistry, McGill University, Montreal, QC, Canada. alexey.kostikov@mcgill.ca. |
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Description: |
Positron emission tomography (PET) is a noninvasive functional imaging modality that involves in vivo detection of spatiotemporal changes in the binding of radioactive pharmaceuticals (a.k.a. PET tracers) to their target sites in different organs. The development of new PET tracers commonly involves their preclinical evaluation in small rodents. Moreover, laboratory animal PET research is now being used with progressively greater frequency to complement human PET studies, to investigate in greater depth the underlying pathophysiology of human diseases, and to monitor the efficiency of novel therapeutic interventions. Here we describe the steps toward a successful small animal PET study, from tracer formulation and image acquisition to data reconstruction and analysis of the acquired scans, with a particular focus on its utility for the brain. |
