BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,164 papers available) |  |
"randomized controlled trial" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial | Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC; | 41795685 HKAP |
| 2 | A randomized controlled trial of an acceptance-based, insight-inducing medication adherence therapy (AIM-AT) for adults with early-stage psychosis | Chien WT; Chong YY; Bressington D; McMaster CW; | 38908265 CONCORDIA |
| 3 | An international, Delphi consensus study to identify priorities for methodological research in behavioral trials in health research. | Byrne M, McSharry J, Meade O, Lavoie KL, Bacon SL | 32293510 HKAP |
| 4 | Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar | Thombs BD; Levis AW; Azar M; Saadat N; Riehm KE; Sanchez TA; Chiovitti MJ; Rice DB; Levis B; Fedoruk C; Lyubenova A; Malo Vázquez de Lara AL; Kloda LA; Benedetti A; Shrier I; Platt RW; Kimmelman J; | 31866472 LIBRARY |
| Title: | Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar | ||||
| Authors: | Thombs BD, Levis AW, Azar M, Saadat N, Riehm KE, Sanchez TA, Chiovitti MJ, Rice DB, Levis B, Fedoruk C, Lyubenova A, Malo Vázquez de Lara AL, Kloda LA, Benedetti A, Shrier I, Platt RW, Kimmelman J | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/31866472/ | ||||
| DOI: | 10.1016/j.jclinepi.2019.12.011 | ||||
| Publication: | Journal of clinical epidemiology | ||||
| Keywords: | Bias; Controlled trials; Methods; RCTs; Randomization; Randomized controlled trials; Research reporting; | ||||
| PMID: | 31866472 | Category: | J Clin Epidemiol | Date Added: | 2019-12-24 |
| Dept Affiliation: |
LIBRARY
1 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada. Electronic address: brett.thombs@mcgill.ca. 2 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada. 3 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. 4 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada. 5 Library, Concordia University, Montreal, Quebec, Canada. 6 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, Quebec, Canada. 7 Studies of Translation, Ethics and Medicine (STREAM), Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada. |
||||
Description: |
Objectives: We evaluated whether sample sizes in different arms of two-arm parallel group randomized controlled trials of nonregulated interventions were systematically closer in size than would plausibly occur by chance if simple randomization had been applied. Study design and setting: We searched PubMed for trials of nonregulated health care interventions that did not report using restricted randomization from journals in behavioral sciences and psychology, nursing, nutrition and dietetics, rehabilitation, and surgery. We emailed trial authors to clarify randomization procedures. Results: We identified 148 nonregulated intervention trials that indicated they used simple randomization. Difference in trial arm sizes was smaller than would be predicted by chance if simple randomization had occurred in all trials (P < 0.001). Rather than approximately half of the trials being within a 50% prediction interval for the difference, 96% had differences within this interval. Results were similar and statistically significant (P < 0.001) for trials that were published in journals with impact factors = 4 and when stratified by type of nonregulated intervention. Conclusion: There is a need for education and better understanding of clinical trial methods to ensure that randomization procedures are implemented as intended and reported fully and accurately. |
