PERFORM Publications

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Title		Authors	PubMed ID
1	Leveraging Personal Technologies in the Treatment of Schizophrenia Spectrum Disorders: Scoping Review	D' Arcey J; Torous J; Asuncion TR; Tackaberry-Giddens L; Zahid A; Ishak M; Foussias G; Kidd S;	39348196 PSYCHOLOGY
2	Ethnoracial Differences in Coercive Referral and Intervention Among Patients With First-Episode Psychosis	Knight S; Jarvis GE; Ryder AG; Lashley M; Rousseau C;	34253035 PSYCHOLOGY
3	Effectiveness of a mindfulness-based psychoeducation group programme for early-stage schizophrenia: An 18-month randomised controlled trial.	Chien WT, Cheng HY, McMaster TW, Yip ALK, Wong JCL	31416744 PSYCHOLOGY
4	High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.	Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG	27154458 CSBN
5	Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.	Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG	28062232 PSYCHOLOGY
6	What Is the Link Between Hallucinations, Dreams, and Hypnagogic-Hypnopompic Experiences?	Waters F, Blom JD, Dang-Vu TT, Cheyne AJ, Alderson-Day B, Woodruff P, Collerton D	27358492 PERFORM

Title:	High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.
Authors:	Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/27154458?dopt=Abstract
DOI:	10.1016/j.yhbeh.2016.04.007
Publication:	Hormones and behavior
Keywords:	Antipsychotic; Dopamine; Estradiol; Ovariectomy; Schizophrenia; fMRI;
PMID:	27154458	Category:	Horm Behav	Date Added:	2019-06-20
Dept Affiliation:	CSBN 1 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6. Electronic address: dan.madularu@gmail.com. 2 Northeastern University, Department of Psychology, Center for Translational Neuroimaging, 360 Huntington Ave, Boston, MA, USA, 02115. 3 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6.

Description:

High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Horm Behav. 2016 06;82:56-63

Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Abstract

The ovarian hormone estrogen has been implicated in schizophrenia symptomatology. Low levels of estrogen are associated with an increase in symptom severity, while exogenous estrogen increases the efficacy of antipsychotic medication, pointing at a possible interaction between estrogen and the dopaminergic system. The aim of this study is to further investigate this interaction in an animal model of some aspects of schizophrenia using awake functional magnetic resonance imaging. Animals receiving 17ß-estradiol and haloperidol were scanned and BOLD activity was assessed in response to amphetamine. High 17ß-estradiol replacement and chronic haloperidol treatment showed increased BOLD activity in regions of interest and neural networks associated with schizophrenia (hippocampal formations, habenula, amygdala, hypothalamus etc.), compared with low, or no 17ß-estradiol. These data show that chronic haloperidol treatment has a sensitizing effect, possibly on the dopaminergic system, and this effect is dependent on hormonal status, with high 17ß-estradiol showing the greatest BOLD increase. Furthermore, these experiments further support the use of imaging techniques in studying schizophrenia, as modeled in the rat, but can be extended to addiction and other disorders.

PMID: 27154458 [PubMed - indexed for MEDLINE]

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