PERFORM Publications

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Title		Authors	PubMed ID
1	Effects of delayed post-polymerization on physical, chemical, and biological properties of a 3D printing interim resin	Choi Y; Comeau P; Lim BS; Manso AP; Chung SH;	41152035 ENCS
2	Understanding the environmental fate and risks of organophosphate esters: Challenges in linking precursors, parent compounds, and derivatives	Li Z; Chen R; Xing C; Zhong G; Zhang X; Jones KC; Zhu Y;	40845576 CHEMBIOCHEM
3	Metal Exposure, Bioaccumulation, and Toxicity Assessment in Sediments from the St. Lawrence River Before and After Remediation Using a Resuspension Technique	Javid M; Mulligan CN; Lefranc M; Rosabal Rodriguez M;	40559906 ENCS
4	Elucidating the toxicity of methyl parathion, imazapic, isoxaflutole, and chlorantraniliprole on human hepatocarcinoma cells and bioinspired membranes	Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA;	40020292 CONCORDIA
5	Evaluation of human vulnerability and toxic effects of chronic and acute occupational exposure to ammonia: A case study in an ice factory	Soltanzadeh A; Mahdinia M; Nikbakht N; Hosseinzadeh K; Sadeghi-Yarandi M;	38143407 ENCS
6	New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines	Orabi MAA; Orabi EA; Awadh AAA; Alshahrani MM; Abdel-Wahab BA; Sakagami H; Hatano T;	38001804 CHEMBIOCHEM
7	Degradation of enrofloxacin by a novel Fe-N-C@ZnO material in freshwater and seawater: Performance and mechanism	Geng C; Chen Q; Li Z; Liu M; Chen Z; Tao H; Yang Q; Zhu B; Feng L;	37619630 ENCS
8	A pH-Responsive phosphoprotein washing fluid for the removal of phenanthrene from contaminated peat moss in the cold region	Yue R; An C; Ye Z; Li X; Li Q; Zhang P; Qu Z; Wan S;	36455665 ENCS
9	Cytotoxicity and Genotoxicity of Azobenzene-Based Polymeric Nanocarriers for Phototriggered Drug Release and Biomedical Applications	Londoño-Berrío M; Pérez-Buitrago S; Ortiz-Trujillo IC; Hoyos-Palacio LM; Orozco LY; López L; Zárate-Triviño DG; Capobianco JA; Mena-Giraldo P;	35956634 CNSR
10	Evaluation of Lanthanide-Doped Upconverting Nanoparticles for in Vitro and in Vivo Applications	Samhadaneh DM; Mandl GA; Han Z; Mahjoob M; Weber SC; Tuznik M; Rudko DA; Capobianco JA; Stochaj U;	35025434 CNSR
11	Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex	Olajide OJ; Chapman CA;	34144329 PSYCHOLOGY
12	Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero	Olajide OJ; Alliy ZO; Ojo DO; Osinubi OO; Bello SO; Ibrahim FE; Adukwu FO; Abikoye TO; Gbadamosi IT; Mutholib NY; Bamisi O; Ajiboye OJ; Okesina AA; Alli-Oluwafuyi A; Oyewole AL; Nafiu AB; Akinola O;	33845156 PSYCHOLOGY
13	Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.	Olajide OJ, Suvanto ME, Chapman CA	33495355 PSYCHOLOGY
14	Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity.	Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, Oluyomi OO, Idowu OK, Kareem R, Asogwa NT, Adeniyi PA	33420680 PSYCHOLOGY
15	Exploration of nanocellulose washing agent for the green remediation of phenanthrene-contaminated soil.	Yin J, Huang G, An C, Zhang P, Xin X, Feng R	33264936 ENCS
16	Exploring the use of cellulose nanocrystal as surface-washing agent for oiled shoreline cleanup.	Chen Z, An C, Yin J, Owens E, Lee K, Zhang K, Tian X	32693337 ENCS

Title:	Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.
Authors:	Olajide OJ, Suvanto ME, Chapman CA
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33495355
DOI:	10.1242/bio.056796
Publication:	Biology open
Keywords:	Alzheimer'; s disease; Amyloid beta protein; Apoptosis; Entorhinal cortex; Excitotoxicity; Glia activation; Inflammation; Oxidative stress; Tau;
PMID:	33495355	Category:	Biol Open	Date Added:	2021-01-27
Dept Affiliation:	PSYCHOLOGY 1 Division of Neurobiology, Department of Anatomy, University of Ilorin, Ilorin, Nigeria, PMB 1515 olajide.oj@unilorin.edu.ng joseph.olajide@concordia.ca andrew.chapman@concordia.ca. 2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, Canada H4B 1R6. 3 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, Canada H4B 1R6 olajide.oj@unilorin.edu.ng joseph.olajide@concordia.ca andrew.chapman@concordia.ca.

Description:

Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.

Biol Open. 2021 Jan 25; 10(1):

Authors: Olajide OJ, Suvanto ME, Chapman CA

Abstract

The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its contributions to cognitive processes and memory formation are supported through its extensive interconnections with the hippocampal formation. During the pathogenesis of Alzheimer's disease (AD), many of the earliest degenerative changes are seen within the EC. Neurodegeneration in the EC and hippocampus during AD has been clearly linked to impairments in memory and cognitive function, and a growing body of evidence indicates that molecular and functional neurodegeneration within the EC may play a primary role in cognitive decline in the early phases of AD. Defining the mechanisms underlying molecular neurodegeneration in the EC is crucial to determining its contributions to the pathogenesis of AD. Surprisingly few studies have focused on understanding the mechanisms of molecular neurodegeneration and selective vulnerability within the EC. However, there have been advancements indicating that early dysregulation of cellular and molecular signaling pathways in the EC involve neurodegenerative cascades including oxidative stress, neuroinflammation, glia activation, stress kinases activation, and neuronal loss. Dysfunction within the EC can impact the function of the hippocampus, which relies on entorhinal inputs, and further degeneration within the hippocampus can compound this effect, leading to severe cognitive disruption. This review assesses the molecular and cellular mechanisms underlying early degeneration in the EC during AD. These mechanisms may underlie the selective vulnerability of neuronal subpopulations in this brain region to the disease development and contribute both directly and indirectly to cognitive loss.This paper has an associated Future Leader to Watch interview with the first author of the article.

PMID: 33495355 [PubMed - in process]

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