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Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments

Author(s): Vandersteen C; Plonka A; Manera V; Sawchuk K; Lafontaine C; Galery K; Rouaud O; Bengaied N; Launay C; Guérin O; Robert P; Allali G; Beauchet O; Gros A;

Introduction: The risk of developing Alzheimer's disease (AD) in older adults increasingly is being discussed in the literature on Post-Acute COVID-19 Syndrome (PACS). Remote digital Assessments for Preclinical AD (RAPAs) are becoming more important in screening for early AD, and should alway ...

Article GUID: 37416323


Assessment of the infiltration of water-in-oil emulsion into soil after spill incidents

Author(s): Qu Z; An C; Yue R; Bi H; Zhao S;

The issue of inland oil spills exerts an adverse impact on environmental and ecological health. Many cases are concerned with water-in-oil emulsions, especially in the oil production and transport system. To understand the contamination and take an efficient response work after spill, this study investigated the infiltration behavior of water-in-oil emuls ...

Article GUID: 37414189


Assessing pragmatics in early childhood with the Language Use Inventory across seven languages

Author(s): Pesco D; O' Neill DK;

The Language Use Inventory (LUI) is a parent-report measure of the pragmatic functions of young children's language, standardized and norm-referenced in English (Canada) for children aged 18-47 months. The unique focus of the LUI, along with its appeal to parents, reliability and validity, and usefulness in both research and clinical contexts has prom ...

Article GUID: 37408974


Dynamic networks differentiate the language ability of children with cochlear implants

Author(s): Koirala N; Deroche MLD; Wolfe J; Neumann S; Bien AG; Doan D; Goldbeck M; Muthuraman M; Gracco VL;

Background: Cochlear implantation (CI) in prelingually deafened children has been shown to be an effective intervention for developing language and reading skill. However, there is a substantial proportion of the children receiving CI who struggle with language and reading. The current study-one ...

Article GUID: 37409105


The more they hear the more they learn? Using data from bilinguals to test models of early lexical development

Author(s): Sander-Montant A; López Pérez M; Byers-Heinlein K;

Children have an early ability to learn and comprehend words, a skill that develops as they age. A critical question remains regarding what drives this development. Maturation-based theories emphasise cognitive maturity as a driver of comprehension, while accumulator theories emphasise children's accumulation of language experience over time. In this ...

Article GUID: 37402336


Preparation, characteristics, and performance of the microemulsion system in the removal of oil from beach sand

Author(s): Bi H; Mulligan CN; Lee K; An C; Wen J; Yang X; Lyu L; Qu Z;

Oil deposited on shoreline substrates has serious adverse effects on the coastal environment and can persist for a long time. In this study, a green and effective microemulsion (ME) derived from vegetable oil was developed as a washing fluid to remove stranded oil from beach sand. The pseudo-ternary phase diagrams of the castor oil/water (without or witho ...

Article GUID: 37399736


Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger

Author(s): Sgro M; Chow N; Olyaei F; Arentshorst M; Geoffrion N; Ram AFJ; Powlowski J; Tsang A;

Bacteria and fungi catabolize plant-derived aromatic compounds by funneling into one of seven dihydroxylated aromatic intermediates, which then undergo ring fission and conversion to TCA cycle intermediates. Two of these intermediates, protocatechuic acid and catechol, converge on ß-ketoadipate which is further cleaved to succinyl-CoA and acetyl-CoA. Thes ...

Article GUID: 37399977


User-friendly and ultra-stable all-inclusive gold tablets for cysteamine detection

Author(s): Al-Kassawneh M; Sadiq Z; Jahanshahi-Anbuhi S;

To date, a range of nanozymes has been reported for their enzyme-mimicking catalytic activity such as solution-based sensors. However, in remote areas, the need for portable, cost-effective, and one-pot prepared sensors is obvious. In this study, we report the development of a highly stable and sensitive gold tablet-based sensor for cysteamine quantificat ...

Article GUID: 37397283


Blocking μ-opioid receptors attenuates reinstatement of responding to an alcohol-predictive conditioned stimulus through actions in the ventral hippocampus

Author(s): Mandy Rita LeCocq

The µ-opioid system is involved in the reinstatement of responding that is immediately evoked by alcohol-predictive cues. The extent of its involvement in reinstatement observed in a new model that evaluates the delayed effects of re-exposure to alcohol, however, is unclear. The current study investigated the role of µ-opioid receptors (MORs) in the delay ...

Article GUID: 37393348


Class imbalance should not throw you off balance: Choosing the right classifiers and performance metrics for brain decoding with imbalanced data

Author(s): Thölke P; Mantilla-Ramos YJ; Abdelhedi H; Maschke C; Dehgan A; Harel Y; Kemtur A; Mekki Berrada L; Sahraoui M; Young T; Bellemare Pépin A; El Khantour C; Landry M; Pascarella A; Hadid V; Combrisson E; O' Byrne J; Jerbi K;

Machine learning (ML) is increasingly used in cognitive, computational and clinical neuroscience. The reliable and efficient application of ML requires a sound understanding of its subtleties and limitations. Training ML models on datasets with imbalanced classes is a particularly common problem, ...

Article GUID: 37385392


Insomnia symptoms among older adults during the first year of the COVID-19 pandemic: A longitudinal study

Author(s): Gong K; Garneau J; Grenier S; Vasiliadis HM; Dang-Vu TT; Dialahy IZ; Gouin JP;

Objective: To identify sociodemographic, psychological, and health factors related to trajectories of insomnia symptoms in older adults during the COVID-19 pandemic. Methods: From May 2020 to May 2021, 644 older adults (mean age = 78.73, SD = 5.60) completed telephone-administered self-reported measures (ie, Insomnia Severity Index, consensus sleep diari ...

Article GUID: 37380593


Divergent directed evolution of a TetR-type repressor towards aromatic molecules

Author(s): Nasr MA; Martin VJJ; Kwan DH;

Reprogramming cellular behaviour is one of the hallmarks of synthetic biology. To this end, prokaryotic allosteric transcription factors (aTF) have been repurposed as versatile tools for processing small molecule signals into cellular responses. Expanding the toolbox of aTFs that recognize new inducer molecules is of considerable interest in many applicat ...

Article GUID: 37377432


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