Author(s): Jaferzadeh K; Fevens T;
Quantitative phase imaging with off-axis digital holography in a microscopic configuration provides insight into the cells' intracellular content and morphology. This imaging is conventionally achieved by numerical reconstruction of the recorded hologram, which requires the precise setting of the reconstruction parameters, including reconstruction d ...
Article GUID: 35991913
Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Németh Z; Sándor E; Kovács B; Fábián I; Kubicek CP; Tsang A; Karaffa L;
High-yield citric acid production by the filamentous Ascomycete fungus Aspergillus niger requires a combination of extreme nutritional conditions, of which maintaining a low manganese (II) ion concentration (-1) is a key feature. Technical-scale production of citric acid predominantly uses stai ...
Article GUID: 35992333
Author(s): Kozlov G; Mattijssen S; Jiang J; Nyandwi S; Sprules T; Iben JR; Coon SL; Gaidamakov S; Noronha AM; Wilds CJ; Maraia RJ; Gehring K;
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif (RRM), together referred to as a La-module, but vary in m ...
Article GUID: 35979957
Author(s): Yousefi R; Panahi Moghaddam SA; Salahi H; Woods R; Abolhasani M; Eini-Zinab H; Saidpour A;
Obesity is associated with maladaptive eating behaviors, including food addiction (FA) and binge eating disorder (BED). However, the key factors influencing the development of maladaptive eating behaviors remain unknown. Adherence to specified dietary patterns has been suspected of making indirect impacts. This study investigates the association of FA a ...
Article GUID: 35975474
Author(s): Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;
We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen Candida albicans. Our system, entitled Candescence, automatically detects C. albicans cells from differential image contrast microscopy and labels each detecte ...
Article GUID: 35972285
Author(s): Ouellette S; Pakarian P; Bin X; Pawelek PD;
Siderophores are high-affinity small-molecule chelators employed by bacteria to acquire iron from the extracellular environment. The Gram-negative bacterium Escherichia coli synthesizes and secretes enterobactin, a tris-catechol siderophore. Enterobactin is synthesized by six cytoplasmic enzyme activities: EntC, EntB (isochorismatase (IC) domain), EntA, ...
Article GUID: 35952947
Author(s): Uthamacumaran A; Zenil H;
Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires the integration of information dynamics across multidimensional spatiotemporal scales, including genetic, transcript ...
Article GUID: 35957879
Author(s): Londoño-Berrío M; Pérez-Buitrago S; Ortiz-Trujillo IC; Hoyos-Palacio LM; Orozco LY; López L; Zárate-Triviño DG; Capobianco JA; Mena-Giraldo P;
Drug nanoencapsulation increases the availability, pharmacokinetics, and concentration efficiency for therapeutic regimes. Azobenzene light-responsive molecules experience a hydrophobicity change from a polar to an apolar tendency by trans-cis photoisomerization upon UV irradiation. Polymeric p ...
Article GUID: 35956634
Author(s): Lacasse JM; Gomez-Perales E; Brake WG;
Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations rega ...
Article GUID: 35952797
Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;
Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
Objectives: Here we investigated the effect of acute food deprivation stress in a novel s ...
Article GUID: 35951079
Author(s): Saillant K; Intzandt B; Bérubé B; Sanami S; Gauthier C; Bherer L;
Background: Physical inactivity significantly increases risk of cardiovascular diseases, which are highly prevalent in aging. Conversely, higher levels of physical activity in aging have been associated with benefits for physical and cognitive health and is hypothesized to prevent and reduce development of cardiovascular risk factors. However, those old ...
Article GUID: 35950796
Author(s): De Visscher A; Pinheiro Patrício PC;
Chemical engineering involves a skill set that is transferrable to a broad range of other areas. A case in point is the work that is being done by chemical engineers to better understand and fight the COVID-19 epidemic. In this study, we consider a problem that has eluded the COVID-19 research community, which is nevertheless very tractable with a chemi ...
Article GUID: 35942051
