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Two Chemical Engineers Look at the COVID-19 Pandemic

Author(s): De Visscher A; Pinheiro Patrício PC;

Chemical engineering involves a skill set that is transferrable to a broad range of other areas. A case in point is the work that is being done by chemical engineers to better understand and fight the COVID-19 epidemic. In this study, we consider a problem that has eluded the COVID-19 research community, which is nevertheless very tractable with a chemi ...

Article GUID: 35942051


Community-led risk analysis of direct-to-consumer whole-genome sequencing

Author(s): Samlali K; Thornbury M; Venter A;

Direct-to-consumer (DTC) genetic testing is cheaper and more accessible than ever before. What is generally hidden from the consumer is the intention to combine, reuse, and resell this genetic information as powerful datasets. This financial gain is creating a competitive DTC market, reducing the price of whole genome sequencing (WGS) down to USD 299. E ...

Article GUID: 35939839


Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex

Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;

Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognition by reducing the function of cholinergic inputs to both the hippocampus and entorhinal cortex. ...

Article GUID: 35939438


Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast

Author(s): Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titorenko VI;

We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different processes, all of which are initiated after yeast cells cultured in a medium initially containing gluc ...

Article GUID: 35937500


Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

Rationale and objective: Learning to inhibit acquired fear responses is fundamental to adaptive behavior. Two procedures that support such learning are extinction and overexpectation. In extinction, an expected outcome is omitted, whereas in overexpectation two individually trained cues are presented in compound to induce an expectation of a greater out ...

Article GUID: 35932299


Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity

Author(s): Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S;

Background: The timing of obesity onset and age have been shown to affect the risk of obesity-related comorbidities, although the impact of each of these factors on markers of adipose tissue function remains unclear. Objective: The aim of this study was to determine whether differences in regional adipose tissue characteristics vary with age and age of ...

Article GUID: 35927468


Assessing effects of predator density and diversity on neophobia in Trinidadian guppies

Author(s): Feyten LEA; Demers EEM; Ramnarine IW; Brown GE;

Neophobic predator avoidance, where prey actively avoid novel stimuli, is thought to allow prey to cope with the inability to predict predation risk (i.e. uncertainty) while reducing the costs associated with learning. Recent studies suggest that neophobia is elicited as a response to unpredictable and elevated mean predation risk, and is linked to expe ...

Article GUID: 35907447


Exploring weight bias internalization in pregnancy

Author(s): Nagpal TS; Salas XR; Vallis M; Piccinini-Vallis H; Alberga AS; Bell RC; da Silva DF; Davenport MH; Gaudet L; Rodriguez ACI; Liu RH; Myre M; Nerenberg K; Nutter S; Russell-Mayhew S; Souza SCS; Vilhan C; Adamo KB;

Background: Recent research has shown that pregnant individuals experience weight stigma throughout gestation, including negative comments and judgement associated with gestational weight gain (GWG). Weight bias internalization (WBI) is often a result of exposure to weight stigma and is detrime ...

Article GUID: 35906530


Contamination analysis of Arctic ice samples as planetary field analogs and implications for future life-detection missions to Europa and Enceladus

Author(s): Coelho LF; Blais MA; Matveev A; Keller-Costa T; Vincent WF; Costa R; Martins Z; Canário J;

Missions to detect extraterrestrial life are being designed to visit Europa and Enceladus in the next decades. The contact between the mission payload and the habitable subsurface of these satellites involves significant risk of forward contamination. The standardization of protocols to decontaminate ice cores from planetary field analogs of icy moons, ...

Article GUID: 35896693


Warming Up With a Dynamic Moment of Inertia Bat Can Increase Bat Swing Speed in Competitive Baseball Players

Author(s): Castonguay T; Roberts M; Dover G;

Introduction: While most baseball players' warm-up with a weighted bat/donut, there is evidence to suggest the swing speed decreases after the warm-up even though the bat feels lighter. Warming up with a dynamic moment of inertia bat may not decrease the swing speed and therefore improve the performance of baseball players. The hypothesis is that a ...

Article GUID: 35894920


Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate

Author(s): Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J;

The infection of a mammalian host by the pathogenic fungus Candida albicans involves fungal resistance to reactive oxygen species (ROS)-induced DNA damage stress generated by the defending macrophages or neutrophils. Thus, the DNA damage response in C. albicans may contribute to its pathogenicity. Uncovering the transcriptional changes triggered by the ...

Article GUID: 35886903


Comparative Analysis of Enzyme Production Patterns of Lignocellulose Degradation of Two White Rot Fungi: Obba rivulosa and Gelatoporia subvermispora

Author(s): Marinovíc M; Di Falco M; Aguilar Pontes MV; Gorzsás A; Tsang A; de Vries RP; Mäkelä MR; Hildén K;

The unique ability of basidiomycete white rot fungi to degrade all components of plant cell walls makes them indispensable organisms in the global carbon cycle. In this study, we analyzed the proteomes of two closely related white rot fungi, Obba rivulosa and Gelatoporia subvermispora, during e ...

Article GUID: 35892327


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