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Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1

Author(s): Kozlov G; Jiang J; Rutherford T; Noronha AM; Wilds CJ; Gehring K;

La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and stabilizing mRNAs and has a unique structure without an RNA binding RRM domain adjoining the LaM domain. In this study, we investigated the physical basis for LARP1 specificity for ...

Article GUID: 39016322


Surviving chlorinated waters: bleaching sensitivity and persistence of free-living amoebae

Author(s): Zahid MT; Mustafa G; Sajid R; Razzaq A; Waheed M; Khan MA; Hwang JH; Park YK; Chung WJ; Jeon BH;

Recent advancements in membrane technologies and disinfection methods have enhanced drinking water quality significantly. However, microorganisms, including free-living amoebae (FLA), persist and pose potential threats to humans. FLA are linked to severe neuro-ophthalmic infections and serve as h ...

Article GUID: 39017868


Measuring what matters to older persons for active living: part II cross-sectional validity evidence for OPAL measure across four countries

Author(s): Mayo NE; Auais M; Barclay R; Branin J; Dawes H; Korfage IJ; Sawchuk K; Tal E; White CL; Ayoubi Z; Ekediegwu E; Mate K; Nadeau L; Rodriguez S; Kuspinar A;

Introduction: Through interviews with 148 older persons from four countries and in four languages, the content for a 17-item measure of active living was developed. The purpose of this paper is to present further evidence of the extent to which this new measure, Older Persons Active Living (OPAL) ...

Article GUID: 39012558


LapBot-Safe Chole: validation of an artificial intelligence-powered mobile game app to teach safe cholecystectomy

Author(s): St John A; Khalid MU; Masino C; Noroozi M; Alseidi A; Hashimoto DA; Altieri M; Serrot F; Kersten-Oertal M; Madani A;

Background: Gaming can serve as an educational tool to allow trainees to practice surgical decision-making in a low-stakes environment. LapBot is a novel free interactive mobile game application that uses artificial intelligence (AI) to provide players with feedback on safe dissection during lapa ...

Article GUID: 39009730


The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity

Author(s): Goldfield GS; Cameron JD; Sigal RJ; Kenny GP; Prud' homme D; Ngu M; Alberga AS; Doucette S; Goldfield DB; Tulloch H; Thai H; Simas KR; Walsh J;

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether ...

Article GUID: 38997217


Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Author(s): Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Candidiasis, which presents a substantial risk to human well-being, is frequently treated with azoles. However, drug-drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, represent serious issues with this class of drug, making it imperative to develop innovative antifungal ...

Article GUID: 38995235


EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy

Author(s): Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C;

Electro/Magneto-EncephaloGraphy (EEG/MEG) source imaging (EMSI) of epileptic activity from deep generators is often challenging due to the higher sensitivity of EEG/MEG to superficial regions and to the spatial configuration of subcortical structures. We previously demonstrated the ability of the ...

Article GUID: 38994740


Neural correlates of impulsivity in amphetamine use disorder

Author(s): Kaboodvand N; Shabanpour M; Guterstam J;

Impulsivity is a trait associated with several psychiatric conditions, not least addictive disorders. While the neural mechanisms behind certain aspects of impulsivity have been studied extensively, there are few imaging studies examining this neurocircuitry in populations with substance use disorders. Therefore, we aimed to examine the functional connect ...

Article GUID: 38991286


Mechanisms and controlling factors of heavy metals removal by electroflocculation in estuarine environments

Author(s): Hadikhani R; Karbassi A; Tajziehchi S; Mehdizadeh Y;

Estuaries play a crucial role in preventing the influx of metals from rivers into seas, thereby offering potential insights for the water purification industry. This study seeks to identify the key parameters (including pH, electricity conductivity (EC), and Eh) influencing the removal efficiency of Mn, Zn, Cu, Co, and Ni during natural and electro-floccu ...

Article GUID: 38991606


Beyond struggle: A strengths-based qualitative study of cannabis use among queer and trans youth in Québec

Author(s): London-Nadeau K; Lafortune C; Gorka C; Lemay-Gaulin M; Séguin J; Haines-Saah R; Ferlatte O; Chadi N; Juster RP; Bristowe S; D' Alessio H; Bernal L; Ellis-Durity K; Barbosa J; Da Costa De Carlos LAAC; Castellanos Ryan N;

Background: Queer and trans (QT) youth report higher rates of cannabis use than their cisgender and heterosexual peers. Explanations for this have overwhelmingly focused on the difficulties QT youth face, while little research has examined how cannabis use can relate to QT youth's strengths. ...

Article GUID: 38991874


Predicting response to stepped-care cognitive behavioral therapy for insomnia using pre-treatment heart rate variability in cancer patients

Author(s): Garneau J; Savard J; Dang-Vu TT; Gouin JP;

Objective: This study examined whether high frequency heart-rate variability (HF-HRV) and HF-HRV reactivity to worry moderate response to cognitive behavioural therapy for insomnia (CBT-I) within both a standard and stepped-care framework among cancer patients with comorbid insomnia. Biomarkers such as HF-HRV may predict response to CBT-I, a finding which ...

Article GUID: 38991424


pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK;

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need ...

Article GUID: 38989606


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