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pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK;

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need ...

Article GUID: 38989606


Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization

Author(s): Memari E; Helfield B;

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease (e.g. atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic deposition. Microbubble-mediated focused ultrasound, which uses circulating, lipid-encapsulated intravascular microbubbles to locally enhance endothelial permeability, offers an ...

Article GUID: 38988819


Exactly Solvable Anharmonic Oscillator, Degenerate Orthogonal Polynomials and Painlevé II

Author(s): Bertola M; Chavez-Heredia E; Grava T;

Using WKB analysis, the paper addresses a conjecture of Shapiro and Tater on the similarity between two sets of points in the complex plane; on one side is the set the values of t ∈ C for which the spectrum of the quartic anharmonic oscillator in the complex plane d 2 y d x 2 - x 4 + t x 2 + 2 J x y = Λ y , with certain boundar ...

Article GUID: 38983592


Cardiac gene delivery using ultrasound: State of the field

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explored as novel non-viral gene delivery vectors for cardiovascular therapy. Given this adaptation to ul ...

Article GUID: 38983873


Characterization of chronic pain, pain interference, and daily pain experiences in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Author(s): Alberts NM; Leisenring W; Whitton J; Stratton K; Jibb L; Flynn J; Pizzo A; Brinkman TM; Birnie K; Gibson TM; McDonald A; Ford J; Olgin JE; Nathan PC; Stinson JN; Armstrong GT;

Although survivors of childhood cancer are at an increased risk, little is known about the prevalence of chronic pain, associated interference, and daily pain experiences. Survivors (N = 233; mean age = 40.8 years, range 22-64 years; mean time since diagnosis = 32.7 years) from the Childhood Canc ...

Article GUID: 38981063


Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics

Author(s): Mosley JD; Dunn WB; Kuligowski J; Lewis MR; Monge ME; Ulmer Holland C; Vuckovic D; Zanetti KA; Schock TB;

Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a QA/QC workshop for LC-MS-based untargeted metabolomics. Objectives: The Best Practices Working Group disseminated recent findings from community forums and ...

Article GUID: 38980450


The effect of EMS, IFC, and TENS on patient-reported outcome measures for chronic low back pain: a systematic review and meta-analysis

Author(s): Wolfe D; Rosenstein B; Fortin M;

Introduction: Chronic low back pain (CLBP) is the leading cause of years lived with disability worldwide. Transcutaneous electrotherapies have been widely used to treat CLBP but, with the partial exception of transcutaneous electrical nerve stimulation (TENS), their effect on pain, disability, quality-of-life, and psychosocial outcomes have not been syste ...

Article GUID: 38979440


A person-centred investigation of the associations between actual and perceived physical fitness among youth with intellectual disabilities

Author(s): Maïano C; Morin AJS; Tracey D; Hue O; Craven RG;

The main objective of this person-centred study was to identify profiles of actual and perceived physical fitness among a sample of youth with intellectual disabilities (ID). Participants were 377 youth (60.4% boys) with mild (49.6%) to moderate (50.4%) ID recruited in Australia and Canada. Latent profile analyses revealed five profiles: (1) Underestimati ...

Article GUID: 38976395


Mechanochemical Synthesis of Boroxine-linked Covalent Organic Frameworks

Author(s): Hamzehpoor E; Effaty F; Borchers TH; Stein RS; Wahrhaftig-Lewis A; Ottenwaelder X; Frišcic T; Perepichka DF;

We report a rapid, room-temperature mechanochemical synthesis of 2- and 3-dimensional boroxine covalent organic frameworks (COFs), enabled by using trimethylboroxine as a dehydrating additive to overcome the hydrolytic sensitivity of boroxine-based COFs. The resulting COFs display high porosity a ...

Article GUID: 38970305


Measuring what matters to older persons for active living: part I content development for the OPAL measure across four countries

Author(s): Mayo NE; Auais M; Barclay R; Branin J; Dawes H; Korfage IJ; Sawchuk K; Tal E; White CL; Ayoubi Z; Chowdhury F; Henderson J; Mansoubi M; Mate KKV; Nadea L; Rodriguez S; Kuspinar A;

Aims: Many older persons do not think of themselves as "patients" but as persons wishing to live as actively as possible for as long as possible. However, most health-related quality of life (HRQL) measures were developed for use with clinical populations. The aim of this project was to fill that ...

Article GUID: 38967870


Connectivity preservation control for multiple unmanned aerial vehicles in the presence of bounded actuation

Author(s): Xue X; Yuan B; Yi Y; Zhang Y; Yue X; Mu L;

This paper proposes a novel multi-unmanned aerial vehicle (UAV) connectivity preservation controller, suitable for scenarios with bounded actuation and limited communication range. According to the hierarchical control strategy, controllers are designed separately for the position and attitude subsystems. A distributed position controller is developed, in ...

Article GUID: 38964998


Weight bias among Canadians: Associations with sociodemographics, BMI and body image constructs

Author(s): Côté M; Forouhar V; Edache IY; Alberga AS;

This cross-sectional study examined the associations between sociodemographic characteristics, BMI, and body image constructs (body satisfaction and weight bias internalization; WBI) and explicit weight bias. A near-representative sample of 995 English-speaking Canadian adults (52% Female) completed a survey which assessed explicit weight bias (Anti-Fat A ...

Article GUID: 38964079


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