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TOUCAN: a framework for fungal biosynthetic gene cluster discovery.

Author(s): Almeida H, Palys S, Tsang A, Diallo AB

Fungal secondary metabolites (SMs) are an important source of numerous bioactive compounds largely applied in the pharmaceutical industry, as in the production of antibiotics and anticancer medications. The discovery of novel fungal SMs can potentially bene...

Article GUID: 33575642
Machine learning for biomedical literature triage.

Author(s): Almeida H, Meurs MJ, Kosseim L, Butler G, Tsang A

PLoS One. 2014;9(12):e115892 Authors: Almeida H, Meurs MJ, Kosseim L, Butler G, Tsang A

Article GUID: 25551575
mycoCLAP, the database for characterized lignocellulose-active proteins of fungal origin: resource and text mining curation support.

Author(s): Strasser K, McDonnell E, Nyaga C, Wu M, Wu S, Almeida H, Meurs MJ, Kosseim L, Powlowski J, Butler G, Tsang A

Database (Oxford). 2015;2015: Authors: Strasser K, McDonnell E, Nyaga C, Wu M, Wu S, Almeida H, Meurs MJ, Kosseim L, Powlowski J, Butler G, Tsang A

Article GUID: 25754864
Title:mycoCLAP, the database for characterized lignocellulose-active proteins of fungal origin: resource and text mining curation support.
Authors:Strasser K,  McDonnell E,  Nyaga C,  Wu M,  Wu S,  Almeida H,  Meurs MJ,  Kosseim L,  Powlowski J,  Butler G,  Tsang A
Link:https://www.ncbi.nlm.nih.gov/pubmed/25754864?dopt=Abstract
DOI:10.1093/database/bav008
Category:Database (Oxford)
PMID:25754864
Dept Affiliation: GENOMICS
1 Centre for Structural and Functional Genomics, Department of Computer Science and Software Engineering, Department of Chemistry and Biochemistry, and Department of Biology Concordia University, Montréal, QC, USA.
2 Centre for Structural and Functional Genomics, Department of Computer Science and Software Engineering, Department of Chemistry and Biochemistry, and Department of Biology Concordia University, Montréal, QC, USA Centre for Structural and Functional Genomics, Department of Computer Science and Software Engineering, Department of Chemistry and Biochemistry, and Department of Biology Concordia University, Montréal, QC, USA.
3 Centre for Structural and Functional Genomics, Department of Computer Science and Software Engineering, Department of Chemistry and Biochemistry, and Department of Biology Concordia University, Montréal, QC, USA Centre for Structural and Functional Genomics, Department of Computer Science and Software Engineering, Department of Chemistry and Biochemistry, and Department of Biology Concordia University, Montréal, QC, USA gregb@encs.concordia.ca.

Description:

mycoCLAP, the database for characterized lignocellulose-active proteins of fungal origin: resource and text mining curation support.

Database (Oxford). 2015;2015:

Authors: Strasser K, McDonnell E, Nyaga C, Wu M, Wu S, Almeida H, Meurs MJ, Kosseim L, Powlowski J, Butler G, Tsang A

Abstract

Enzymes active on components of lignocellulosic biomass are used for industrial applications ranging from food processing to biofuels production. These include a diverse array of glycoside hydrolases, carbohydrate esterases, polysaccharide lyases and oxidoreductases. Fungi are prolific producers of these enzymes, spurring fungal genome sequencing efforts to identify and catalogue the genes that encode them. To facilitate the functional annotation of these genes, biochemical data on over 800 fungal lignocellulose-degrading enzymes have been collected from the literature and organized into the searchable database, mycoCLAP (http://mycoclap.fungalgenomics.ca). First implemented in 2011, and updated as described here, mycoCLAP is capable of ranking search results according to closest biochemically characterized homologues: this improves the quality of the annotation, and significantly decreases the time required to annotate novel sequences. The database is freely available to the scientific community, as are the open source applications based on natural language processing developed to support the manual curation of mycoCLAP. Database URL: http://mycoclap.fungalgenomics.ca.

PMID: 25754864 [PubMed - indexed for MEDLINE]