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Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.

Author(s): Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Cereb Cortex. 2018 Oct 06;: Authors: Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Article GUID: 30295713
Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats.

Author(s): Yetnikoff L, Arvanitogiannis A

Behav Brain Funct. 2013 Oct 17;9:38 Authors: Yetnikoff L, Arvanitogiannis A

Article GUID: 24134881
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.

Author(s): Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Biol Psychiatry. 2014 Mar 15;75(6):487-98 Authors: Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Article GUID: 24138924
Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.

Author(s): Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S

Neuropsychopharmacology. 2016 Feb;41(3):811-21 Authors: Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S

Article GUID: 26171719
Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA.

Author(s): Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C

Neuropsychopharmacology. 2018 03;43(4):900-911 Authors: Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C

Article GUID: 29154364
Adolescent Exposure to Methylphenidate Increases Impulsive Choice Later in Life.

Author(s): Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A

Front Behav Neurosci. 2017;11:214 Authors: Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A

Article GUID: 29163086
Title:Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.
Authors:Hryhorczuk C,  Florea M,  Rodaros D,  Poirier I,  Daneault C,  Des Rosiers C,  Arvanitogiannis A,  Alquier T,  Fulton S
Link:https://www.ncbi.nlm.nih.gov/pubmed/26171719?dopt=Abstract
Category:Neuropsychopharmacology
PMID:26171719
Dept Affiliation: CSBN
1 Centre de Recherche du CHUM and Montreal Diabetes Research Center, Montreal, QC, Canada.
2 Department of Physiology, Université de Montréal, Montreal, QC, Canada.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
4 Department of Nutrition, Université de Montréal, Montreal, QC, Canada.
5 Montreal Heart Institute, Montreal, QC, Canada.
6 Department of Medicine, Université de Montréal, Montreal, QC, Canada.

Description:

Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.

Neuropsychopharmacology. 2016 Feb;41(3):811-21

Authors: Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S

Abstract

Overconsumption of dietary fat is increasingly linked with motivational and emotional impairments. Human and animal studies demonstrate associations between obesity and blunted reward function at the behavioral and neural level, but it is unclear to what degree such changes are a consequence of an obese state and whether they are contingent on dietary lipid class. We sought to determine the impact of prolonged ad libitum intake of diets rich in saturated or monounsaturated fat, separate from metabolic signals associated with increased adiposity, on dopamine (DA)-dependent behaviors and to identify pertinent signaling changes in the nucleus accumbens (NAc). Male rats fed a saturated (palm oil), but not an isocaloric monounsaturated (olive oil), high-fat diet exhibited decreased sensitivity to the rewarding (place preference) and locomotor-sensitizing effects of amphetamine as compared with low-fat diet controls. Blunted amphetamine action by saturated high-fat feeding was entirely independent of caloric intake, weight gain, and plasma levels of leptin, insulin, and glucose and was accompanied by biochemical and behavioral evidence of reduced D1R signaling in the NAc. Saturated high-fat feeding was also tied to protein markers of increased AMPA receptor-mediated plasticity and decreased DA transporter expression in the NAc but not to alterations in DA turnover and biosynthesis. Collectively, the results suggest that intake of saturated lipids can suppress DA signaling apart from increases in body weight and adiposity-related signals known to affect mesolimbic DA function, in part by diminishing D1 receptor signaling, and that equivalent intake of monounsaturated dietary fat protects against such changes.

PMID: 26171719 [PubMed - indexed for MEDLINE]