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Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review.

Author(s): Badilescu S, Raju D, Bathini S, Packirisamy M

Nano-islands are entities (droplets or other shapes) that are formed by spontaneous dewetting (agglomeration, in the early literature) of thin and very thin metallic (especially gold) films on a substrate, done by post-deposition heating or by using other s...

Article GUID: 33066088
Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Author(s): Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Int J Mol Sci. 2019 Dec 05;20(24): Authors: Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Article GUID: 31817343
Nano-Bio Interactions of Extracellular Vesicles with Gold Nanoislands for Early Cancer Diagnosis.

Author(s): Bathini S, Raju D, Badilescu S, Kumar A, Ouellette RJ, Ghosh A, Packirisamy M

Res (Wash D C). 2018;2018:3917986 Authors: Bathini S, Raju D, Badilescu S, Kumar A, Ouellette RJ, Ghosh A, Packirisamy M

Article GUID: 31549028
Tuning of Morphology and Stability of Gold Nanostars Through pH Adjustment.

Author(s): Kumar R, Badilescu S, Packirisamy M

J Nanosci Nanotechnol. 2019 Aug 01;19(8):4617-4622 Authors: Kumar R, Badilescu S, Packirisamy M

Article GUID: 30913757
The effect of hydrogen nanobubbles on the morphology of gold-gelatin bionanocomposite films and their optical properties.

Author(s): Alsawafta M, Badilescu S, Truong VV, Packirisamy M

Nanotechnology. 2012 Feb 17;23(6):065305 Authors: Alsawafta M, Badilescu S, Truong VV, Packirisamy M

Article GUID: 22248640
Title:Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.
Authors:Subramaniyan Parimalam S,  Badilescu S,  Sonenberg N,  Bhat R,  Packirisamy M
Link:https://www.ncbi.nlm.nih.gov/pubmed/31817343?dopt=Abstract
DOI:10.3390/ijms20246126
Category:Int J Mol Sci
PMID:31817343
Dept Affiliation: ENCS
1 Optical-Bio Microsystems Laboratory, Micro-Nano-Bio Integration Center, Department of Mechanical and Industrial Engineering, Concordia University, Montreal, QC H3G 2W1, Canada.
2 Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.
3 Department of Mechanical and Industrial Engineering, Concordia University, Montreal, QC H3G 2W1, Canada.

Description:

Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Int J Mol Sci. 2019 Dec 05;20(24):

Authors: Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Abstract

There is a huge demand for pro-/anti-angiogenic nanomedicines to treat conditions such as ischemic strokes, brain tumors, and neurodegenerative diseases such as Alzheimer's and Parkinson's. Nanomedicines are therapeutic particles in the size range of 10-1000 nm, where the drug is encapsulated into nano-capsules or adsorbed onto nano-scaffolds. They have good blood-brain barrier permeability, stability and shelf life, and able to rapidly target different sites in the brain. However, the relationship between the nanomedicines' physical and chemical properties and its ability to travel across the brain remains incompletely understood. The main challenge is the lack of a reliable drug testing model for brain angiogenesis. Recently, microfluidic platforms (known as "lab-on-a-chip" or LOCs) have been developed to mimic the brain micro-vasculature related events, such as vasculogenesis, angiogenesis, inflammation, etc. The LOCs are able to closely replicate the dynamic conditions of the human brain and could be reliable platforms for drug screening applications. There are still many technical difficulties in establishing uniform and reproducible conditions, mainly due to the extreme complexity of the human brain. In this paper, we review the prospective of LOCs in the development of nanomedicines for brain angiogenesis-related conditions.

PMID: 31817343 [PubMed - in process]