PERFORM Publications

Title:	Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.
Authors:	Booij L , Welfeld K , Leyton M , Dagher A , Boileau I , Sibon I , Baker GB , Diksic M , Soucy JP , Pruessner JC , Cawley-Fiset E , Casey KF , Benkelfat C
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26905412?dopt=Abstract
Category:	Transl Psychiatry
PMID:	26905412
Dept Affiliation:	PSYCHOLOGY 1 Department of Psychology, Concordia University, Montreal, QC, Canada. 2 CHU Sainte Justine Hospital Research Center, University of Montreal, Montreal, QC, Canada. 3 Department of Psychiatry, McGill University, Montreal, QC, Canada. 4 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. 5 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. 6 Center for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. 7 Pole de Neurosciences Cliniques, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France. 8 Neurobiology Research Unit, Department of Psychiatry, Institute of Neuroscience and Mental Health, University of Alberta, Edmonton, AB, Canada. 9 Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Description:

Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.

Transl Psychiatry. 2016 Feb 23;6:e740

Authors: Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C

Abstract

Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ? 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P < 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P < 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked.

PMID: 26905412 [PubMed - indexed for MEDLINE]

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