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Effects of Cholesterol on the Thermodynamics and Kinetics of Passive Transport of Water through Lipid Membranes

Author(s): Bilkiss B Issack

While it has long been known that cholesterol reduces the permeability of biological membranes to water, the exact mechanism by which cholesterol influences transmembrane permeation is still unclear. The thermodynamic and kinetic contributions to the transp...

Article GUID: 25679811
Title:Effects of Cholesterol on the Thermodynamics and Kinetics of Passive Transport of Water through Lipid Membranes
Authors:Bilkiss B Issack
Link:https://pubmed.ncbi.nlm.nih.gov/25679811/
DOI:10.1021/jp510497r
Category:
PMID:25679811
Dept Affiliation: CHEMBIOCHEM
1 Centre for Research in Molecular Modeling and Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Québec H4B 1R6, Canada.

Description:

While it has long been known that cholesterol reduces the permeability of biological membranes to water, the exact mechanism by which cholesterol influences transmembrane permeation is still unclear. The thermodynamic and kinetic contributions to the transport of water across mixed DPPC/cholesterol bilayers of different composition are thus examined by molecular dynamics simulations. Our analyses show that cholesterol decreases transmembrane permeability to water mainly by altering the...