Keyword search (3,619 papers available)


Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.

Author(s): Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij...

Previous research has shown that the prenatal environment, commonly indexed by birth weight (BW), is a predictor of morphological brain development. We previously showed in monozygotic (MZ) twins a...

Article GUID: 32881198
mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Author(s): Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl R...

Neuropsychopharmacology. 2020 May 15;: Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, C...

Article GUID: 32413893
Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Author(s): Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Ségu...

Neuropsychopharmacology. 2020 Apr 07;: Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, S&...

Article GUID: 32259831
Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Author(s): Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Hum Brain Mapp. 2017 04;38(4):2037-2050 Authors: Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 28032437
Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Author(s): Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Transl Psychiatry. 2018 08 08;8(1):147 Authors: Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 30089832
Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.

Author(s): Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1175-1178 Authors: Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Article GUID: 30607444
Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Author(s): Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183 Authors: Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Article GUID: 30627817
Title:Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.
Authors:Smart K,  Cox SML,  Scala SG,  Tippler M,  Jaworska N,  Boivin M,  Séguin JR,  Benkelfat C,  Leyton M
Link:https://www.ncbi.nlm.nih.gov/pubmed/30627817?dopt=Abstract
Category:Eur J Nucl Med Mol Imaging
PMID:30627817
Dept Affiliation: CSBN
1 Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada.
2 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
3 Institute of Mental Health Research, affiliated with the University of Ottawa, Ottawa, ON, K1Z 7K4, Canada.
4 Department of Psychology, Université Laval, Quebec City, QC, G1V 0A6, Canada.
5 CHU Ste-Justine Research Center, Montreal, QC, H3T 1C5, Canada.
6 Department of Psychiatry and Addiction, Université de Montréal, Montreal, QC, H3T 1J4, Canada.
7 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
8 Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada. marco.leyton@mcgill.ca.
9 CHU Ste-Justine Research Center, Montreal, QC, H3T 1C5, Canada. marco.leyton@mcgill.ca.
10 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada. marco.leyton@mcgill.ca.
11 Department of Psychology, McGill University, Montreal, QC, H3G 1G1, Canada. marco.leyton@mcgill.ca.
12 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, H4B 1R6, Canada. marco.leyton@mcgill.ca.

Description:

Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183

Authors: Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Abstract

PURPOSE: The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [11C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor.

METHODS: High resolution [11C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20?±?3.0). Mean binding potential (BPND?=?fND * (Bavail / KD)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region.

RESULTS: [11C]ABP688 BPND was significantly higher in men compared to women in the prefrontal cortex (p?<?0.01), striatum (p?<?0.001), and hippocampus (p?<?0.05). Whole-brain BPND was 17% higher in men. BPND was not related to menstrual phase in women.

CONCLUSIONS: Binding availability of mGlu5 receptors as measured by PET [11C]ABP688 is higher in healthy men than women. This likely represents a source of variability in [11C]ABP688 studies and could have relevance for sex differences in cognitive-behavioral functions and neuropsychiatric disorders.

PMID: 30627817 [PubMed - in process]