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Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia.

Author(s): Pomares FB, Boucetta S, Lachapelle F, Steffener J, Montplaisir J, Cha J, Kim H, Dang-Vu TT

Sleep. 2019 Jul 22;: Authors: Pomares FB, Boucetta S, Lachapelle F, Steffener J, Montplaisir J, Cha J, Kim H, Dang-Vu TT

Article GUID: 31328786
Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease.

Author(s): Boucetta S, Salimi A, Dadar M, Jones BE, Collins DL, Dang-Vu TT

Sci Rep. 2016 06 01;6:26782 Authors: Boucetta S, Salimi A, Dadar M, Jones BE, Collins DL, Dang-Vu TT

Article GUID: 27245317
Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia.

Author(s): Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT

Sleep. 2017 10 01;40(10): Authors: Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT

Article GUID: 28958044
Title:Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease.
Authors:Boucetta S,  Salimi A,  Dadar M,  Jones BE,  Collins DL,  Dang-Vu TT
Link:https://www.ncbi.nlm.nih.gov/pubmed/27245317?dopt=Abstract
DOI:10.1038/srep26782
Category:Sci Rep
PMID:27245317
Dept Affiliation: PERFORM
1 Center for Studies in Behavioural Neurobiology, PERFORM Center and Dpt of Exercise Science, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec, H4B 1R6 Canada.
2 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal and Dpt of Neurosciences, Université de Montréal, 4545 Chemin Queen Mary, Montréal, Québec, H3W 1W4 Canada.
3 Montreal Neurological Institute, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4 Canada.

Description:

Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease.

Sci Rep. 2016 06 01;6:26782

Authors: Boucetta S, Salimi A, Dadar M, Jones BE, Collins DL, Dang-Vu TT

Abstract

Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson's disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples of magnetic resonance imaging (MRI) scans in 69 PD patients with probable RBD, 240 patients without RBD and 138 healthy controls, using deformation-based morphometry (p?<?0.05 corrected for multiple comparisons). All data were extracted from the Parkinson's Progression Markers Initiative. PD patients with probable RBD showed smaller volumes than patients without RBD and than healthy controls in the pontomesencephalic tegmentum, medullary reticular formation, hypothalamus, thalamus, putamen, amygdala and anterior cingulate cortex. These results demonstrate that RBD is associated with a prominent loss of volume in the pontomesencephalic tegmentum, where cholinergic, GABAergic and glutamatergic neurons are located and implicated in the promotion of REM sleep and muscle atonia. It is additionally associated with more widespread atrophy in other subcortical and cortical regions whose loss also likely contributes to the altered regulation of sleep-wake states and motor activity underlying RBD in PD patients.

PMID: 27245317 [PubMed - indexed for MEDLINE]